Plasmids carrying DHA-1 β-lactamases

  • Claire Hennequin
  • Viviane Ravet
  • Frédéric Robin


The aim of this review is to provide an update on the plasmids mediating DHA-1 cephalosporinase in Klebsiella pneumoniae. These plasmids have been mainly found in this bacterium but not only. The first was isolated from Salmonella sp. in France in the early 1990s. They are currently reported worldwide. BlaDHA-1 beta-lactamase gene is usually co-expressed with many other antibiotic resistance genes such as extended-spectrum β-lactamases (blaCTX-M-, bla SHV -types), oxacillinases (blaOXA-1, blaOXA-30), penicillinases (bla TEM -type), carbapenemases (bla OXA48 , blaKPC-2), aminoglycosides (aacA, aadA, armA), fluoroquinolones (qnrB4, aac6′-1b-cr), and sulfonamide (sul1) resistance genes. Plasmids carrying DHA-1 cephalosporinase have different sizes (22 to 313 kb), belong to diverse groups of incompatibility (R, L/M, FII(k), FIB, A/C2, HI2, HIB), and are self-transferable or not. The multidrug resistance region consists of a mosaic structure composed of resistance genes, insertion sequences, composite transposon, and integrons.


Plasmids AmpC DHA-1 Cephalosporinase Antibiotic resistance Klebsiella pneumoniae 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Claire Hennequin
    • 1
    • 2
  • Viviane Ravet
    • 1
  • Frédéric Robin
    • 2
    • 3
    • 4
  1. 1.Université Clermont Auvergne, CNRS, Laboratoire Microorganismes: Génome et EnvironnementClermont-FerrandFrance
  2. 2.Laboratoire de BactériologieCHU Clermont-FerrandClermont-FerrandFrance
  3. 3.Université Clermont Auvergne, UMR INSERM 1071, USC INRA2018Clermont-FerrandFrance
  4. 4.Laboratoire associé Résistance des Entérobactéries BLSE/CéphalosporinasesCentre National de Référence Résistance aux AntibiotiquesClermont-FerrandFrance

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