Coagulase-negative staphylococci are associated to the mild inflammatory pattern of healthcare-associated meningitis: a retrospective study

  • S. Couffin
  • D. Lobo
  • F. Cook
  • P. H. Jost
  • V. Bitot
  • R. Birnbaum
  • B. Nebbad
  • B. Aït-Mamar
  • W. Lahiani
  • M. Martin
  • G. Dhonneur
  • R. Mounier
Original Article


The epidemiology of healthcare-associated meningitis (HAM) is dominated by commensal bacteria from the skin, as coagulase-negative staphylococci (CoNS). We hypothesized that the pauci-symptomatic and mild inflammatory patterns of HAM are related to the low pathogenic state of CoNS. Our aim was to describe clinical and biological features of CoNS HAM, compared to other HAM. All consecutive patients with HAM admitted in our hospital were retrospectively included from 2007 to 2014. HAM due to CoNS were compared to HAM caused by other bacteria (controls) for clinical and laboratory patterns. Seventy-one cases of HAM were included, comprising 18 CoNS and 53 controls. Patients were not different in terms of baseline characteristics. CoNS HAM occurred later after the last surgery than controls (17 vs. 12 days, p = 0.029) and had higher Glasgow Coma Scale (GCS) score (14 vs. 13, p = 0.038). Cerebrospinal fluid (CSF) analysis revealed a lower pleocytosis (25 vs. 1340/mm3, p < 0.001), a higher glucose level (3.75 vs. 0.8 mmol/L, p < 0.001), and a lower protein level (744 vs. 1751 mg/L, p < 0.001) in the CoNS group than in the control group, respectively. HAM due to CoNS was significantly less symptomatic and less inflammatory than HAM due to other bacteria.


Source of funding


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study was approved by the local ethical committee. All procedures were in accordance with the ethical standards of the national research committee and with the 1964 Helsinki declaration and its later amendments. For this type of study (retrospective), formal consent is not required.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Anaesthesia and Surgical Intensive CareHenri Mondor University Hospital of Paris, Paris XII School of MedicineCréteilFrance
  2. 2.Department of MicrobiologyHenri Mondor University Hospital of Paris, Paris XII School of MedicineCréteilFrance
  3. 3.Department of NeurosurgeryHenri Mondor University Hospital of Paris, Paris XII School of MedicineCréteilFrance

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