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Serious fungal infections in Thailand

European Journal of Clinical Microbiology & Infectious Diseases volume 36, pages 931–935 (2017)Cite this article

Abstract

The burden of serious fungal infection in Thailand is increasing but data regarding its incidence and prevalence are lacking. In this study we aimed to estimate the burden of serious fungal diseases in Thailand based on the size of the populations at risk and available epidemiological databases. Data derived from The Bureau of Epidemiology, Department of Disease Control, Thai Ministry of Public Health, World Health Organisation, international and local reports, and some unreported data were used. When no data existed, risk populations were used to estimate frequencies of fungal infections, using previously described methodology by LIFE. Recurrent vulvovaginal candidiasis (>4 episodes per year) is estimated to occur in 3,310 per 100,000 population. Using a previously described rate that 14/10,000 admissions are with fungaemia and 94% of those are Candida, we estimated 8,650 patients with candidaemia. The prevalence of chronic pulmonary aspergillosis is relatively high with a total of 19,044, approximately half subsequent to pulmonary tuberculosis. Invasive aspergillosis is estimated to affect 941 patients following leukaemia therapy, transplantations, and chronic obstructive pulmonary disease, approximately 1.4/100,000. In addition, allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitisation were estimated at approximately 58.4/100,000 and 77/100,000, respectively. Given approximately 8,134 new cases of AIDS annually, cryptococcal meningitis, Pneumocystis pneumonia, and Talaromyces marneffei infection are estimated at 1.9/100,000, 2.6/100,000, and 0.3/100,000, respectively. The present study indicates that about 1.93% (1,254,562) of the population is affected by serious fungal infections. Owing to the lack of data, reports, and statistics, the number of patients with mycoses in Thailand can only be estimated.

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References

  1. Hsu LY, Lee DG, Yeh SP, Bhurani D, Khanh BQ, Low CY et al (2015) Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: a prospective observational study. Clin Microbiol Infect 21(594):e597–511

    Google Scholar 

  2. Faksri K, Kaewkes W, Chaicumpar K, Chaimanee P, Wongwajana S (2014) Epidemiology and identification of potential fungal pathogens causing invasive fungal infections in a tertiary care hospital in northeast Thailand. Med Mycol 52:810–818

    Article  PubMed  Google Scholar 

  3. Chayakulkeeree M, Perfect JR (2006) Cryptococcosis. Infect Dis Clin North Am 20:507–544

    Article  PubMed  Google Scholar 

  4. Chayakulkeeree M, Vongwiwatana A (2014) Invasive mold infection in kidney transplant recipients: observation of early-onset mucormycosis. Transplant Proc 46:595–597

    CAS  Article  PubMed  Google Scholar 

  5. Apisarnthanarak A, Naknarongkij N, Kiratisin P, Mundy LM (2009) Risk factors and outcomes of Candida albicans and non-albicans Candida species at a Thai tertiary care center. Am J Infect Control 37:781–782

    Article  PubMed  Google Scholar 

  6. Gamaletsou MN, Drogari-Apiranthitou M, Denning DW, Sipsas NV (2016) An estimate of the burden of serious fungal diseases in Greece. Eur J Clin Microbiol Infect Dis 35:1115–1120

    CAS  Article  PubMed  Google Scholar 

  7. Dejsomritrutai W, Nana A, Chierakul N, Tscheikuna J, Sompradeekul S, Ruttanaumpawan P et al (2006) Prevalence of bronchial hyperresponsiveness and asthma in the adult population in Thailand. Chest 129:602–609

    Article  PubMed  Google Scholar 

  8. Ekpunyasakul C (2010) Epidemiology of adult leukemia: A descriptive study. Thai Cancer J 30:77–83

    Google Scholar 

  9. Issaragrisil S (2008) Hematopoietic stem cell transplantation in Thailand. Bone Marrow Transplant 42(Suppl 1):S137–S138

    Article  PubMed  Google Scholar 

  10. Sobel JD (2016) Recurrent vulvovaginal candidiasis. Am J Obstet Gynecol 214:15–21

    Article  PubMed  Google Scholar 

  11. Ringdahl EN (2000) Treatment of recurrent vulvovaginal candidiasis. Am Fam Physician 61(3306–3312):3317

    Google Scholar 

  12. Sobel JD (2007) Vulvovaginal candidosis. Lancet 369:1961–1971

    Article  PubMed  Google Scholar 

  13. Anunnatsiri S, Chetchotisakd P, Mootsikapun P (2009) Fungemia in non-HIV-infected patients: a five-year review. Int J Infect Dis 13:90–96

    Article  PubMed  Google Scholar 

  14. Smith E, Orholm M (1990) Trends and patterns of opportunistic diseases in Danish AIDS patients 1980–1990. Scand J Infect Dis 22:665–672

    CAS  Article  PubMed  Google Scholar 

  15. Buchacz K, Baker RK, Palella FJ Jr, Chmiel JS, Lichtenstein KA, Novak RM et al (2010) AIDS-defining opportunistic illnesses in US patients, 1994–2007: a cohort study. AIDS 24:1549–1559

    Article  PubMed  Google Scholar 

  16. Jaijakul S, Saksirisampant W, Prownebon J, Yenthakam S, Mungthin M, Leelayoova S et al (2005) Pneumocystis jiroveci in HIV/AIDS patients: detection by FTA filter paper together with PCR in noninvasive induced sputum specimens. J Med Assoc Thai 88(Suppl 4):S294–S299

    PubMed  Google Scholar 

  17. Lindsley MD, Mekha N, Baggett HC, Surinthong Y, Autthateinchai R, Sawatwong P et al (2011) Evaluation of a newly developed lateral flow immunoassay for the diagnosis of cryptococcosis. Clin Infect Dis 53:321–325

    Article  PubMed  PubMed Central  Google Scholar 

  18. Harris JR, Lindsley MD, Henchaichon S, Poonwan N, Naorat S, Prapasiri P et al (2012) High prevalence of cryptococcal infection among HIV-infected patients hospitalized with pneumonia in Thailand. Clin Infect Dis 54:e43–e50

    Article  PubMed  Google Scholar 

  19. Chayakulkeeree M, Wangchinda P (2014) Clinical characteristics and outcomes of patients with cryptococcal meningoencephalitis in a resource-limited setting. J Med Assoc Thai 97(Suppl 3):S26–S34

    PubMed  Google Scholar 

  20. Denning DW, Pleuvry A, Cole DC (2011) Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis. Bull World Health Organ 89:864–872

    Article  PubMed  PubMed Central  Google Scholar 

  21. Lortholary O, Gangneux JP, Sitbon K, Lebeau B, de Monbrison F, Le Strat Y et al (2011) Epidemiological trends in invasive aspergillosis in France: the SAIF network (2005–2007). Clin Microbiol Infect 17:1882–1889

    CAS  Article  PubMed  Google Scholar 

  22. Perkhofer S, Lass-Florl C, Hell M, Russ G, Krause R, Honigl M et al (2010) The Nationwide Austrian Aspergillus Registry: a prospective data collection on epidemiology, therapy and outcome of invasive mould infections in immunocompromised and/or immunosuppressed patients. Int J Antimicrob Agents 36:531–536

    CAS  Article  PubMed  Google Scholar 

  23. Ma YL, Zhang WB, Yu B, Chen YW, Mu S, Cui YL (2011) Prevalence of allergic bronchopulmonary aspergillosis in Chinese patients with bronchial asthma. Zhonghua Jie He He Hu Xi Za Zhi 34:909–913

    PubMed  Google Scholar 

  24. Denning DW, Pleuvry A, Cole DC (2013) Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults. Med Mycol 51:361–370

    Article  PubMed  Google Scholar 

  25. Chetchotisakd P, Boonma P, Sookpranee M, Pairojkul C (1991) Rhinocerebral mucormycosis: a report of eleven cases. Southeast Asian J Trop Med Public Health 22:268–273

    CAS  PubMed  Google Scholar 

  26. Hirunpat C, Masae N (2005) Fungal keratitis in Songklanagarind Hospital. Songkla Med J 23:429–434

    Google Scholar 

  27. World Health Organization (2004) Guidelines for the management of corneal ulcer at primary, secondary and tertiary care health facilities in the South-East Asia region. WHO, Regional Office for South-East Asia

  28. Khwakhali US, Denning DW (2015) Burden of serious fungal infections in Nepal. Mycoses 58(Suppl 5):45–50

    Article  PubMed  Google Scholar 

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Affiliations

  1. Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand

    M. Chayakulkeeree

  2. The National Aspergillosis Centre in association with the LIFE program at www.LIFE-worldwide.org, The University of Manchester, Manchester, UK

    D. W. Denning

Authors
  1. M. Chayakulkeeree
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  2. D. W. Denning
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Correspondence to M. Chayakulkeeree.

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Chayakulkeeree, M., Denning, D.W. Serious fungal infections in Thailand. Eur J Clin Microbiol Infect Dis 36, 931–935 (2017). https://doi.org/10.1007/s10096-017-2927-6

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  • DOI: https://doi.org/10.1007/s10096-017-2927-6

Keywords

  • Chronic Obstructive Pulmonary Disease
  • Invasive Aspergillosis
  • Acquire Immune Deficiency Syndrome
  • Cryptococcosis
  • Cryptococcal Meningitis