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Setting up an outpatient parenteral antimicrobial therapy (OPAT) unit in Switzerland: review of the first 18 months of activity

European Journal of Clinical Microbiology & Infectious Diseases volume 35, pages 839–845 (2016)Cite this article

Abstract

Outpatient parenteral antimicrobial therapy (OPAT) has been recognised as a useful, cost-effective and safe alternative to inpatient treatment, but no formal OPAT unit existed in Switzerland until recently. In December 2013 an OPAT unit was established at Lausanne University Hospital. We review here the experience of this new OPAT unit after 18 months of activity. Patient characteristics, clinical activities and outcomes were recorded prospectively. Need and acceptance was evaluated as number of OPAT courses administered and number of patients refusing OPAT. Safety and efficacy were evaluated as: (1) adverse events linked to antimicrobials and catheters, (2) re-admission to hospital, (3) rate of treatment failures and (4) mortality. Over 18 months, 179 courses of OPAT were administered. Acceptance was high with only four patients refusing OPAT. Urinary tract infections with resistant bacteria and musculoskeletal infections were the most common diagnoses. Self-administration of antibiotics using elastomeric pumps became rapidly the most frequently used approach. Sixteen patients presented with adverse events linked to antimicrobials and catheters. OPAT-related readmissions occurred in nine patients. The overall cure rate was 94 %. This study shows that OPAT is very well accepted by patients and medical staff, even in a setting which has not used this type of treatment approach until now. Self-administration using elastomeric pumps proved to be particularly useful, safe and efficient. OPAT offers a good alternative to hospitalisation for patients presenting with infections due to resistant bacteria that cannot be treated orally anymore and for difficult to treat infections.

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Acknowledgments

The authors would like to acknowledge all of the OPAT nursing staff and Tony Chapman for his critical reading.

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Affiliations

  1. Service of Infectious Diseases, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, 1011, Lausanne, Switzerland

    C. Gardiol & S. de Vallière

  2. Service of Internal Medicine, Department of Medicine, Lausanne University Hospital, Rue du Bugnon 46, 1011, Lausanne, Switzerland

    R. Voumard

  3. Department of Outpatient Care and Community Medicine, Rue du Bugnon 44, 1011, Lausanne, Switzerland

    C. Cochet & S. de Vallière

Authors
  1. C. Gardiol
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  2. R. Voumard
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  3. C. Cochet
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  4. S. de Vallière
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Corresponding author

Correspondence to C. Gardiol.

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Funding

The initiation of the OPAT unit of the University Hospital of Lausanne was supported by a grant from the Swiss Society of General Internal Medicine Foundation.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Gardiol, C., Voumard, R., Cochet, C. et al. Setting up an outpatient parenteral antimicrobial therapy (OPAT) unit in Switzerland: review of the first 18 months of activity. Eur J Clin Microbiol Infect Dis 35, 839–845 (2016). https://doi.org/10.1007/s10096-016-2606-z

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  • DOI: https://doi.org/10.1007/s10096-016-2606-z

Keywords

  • Intermittent Infusion
  • Ertapenem
  • Flucloxacillin
  • Intravenous Antibiotic Therapy
  • Prosthetic Infection