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Genotype-specific concordance of oral and genital human papillomavirus infections among marital couples is low

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Abstract

Data on genotype-specific concordance of oral-oral and genital-oral HPV infections among marital couples are key to understand HPV transmission between spouses. Genotype-specific concordance of HPV infections (oral/genital) and their co-variates among 131 marital couples were determined during 6-year follow-up (FU). Seven oral scrapings were taken from both spouses, accompanied by six genital samplings from the women and one (at baseline) from the male partners. HPV-genotyping was performed by nested PCR and a Luminex®-based Multimetrix Assay. Demographic data were collected with questionnaires at baseline and study conclusion. Prevalence of oral HPV varied from 10.3 to 27.0 % and 15.8 to 31.3 % in women and men, respectively. At baseline, 37.6 % of the male genital samples were HPV-positive while in female genital samples, HPV prevalence varied from 13.3 to 59.4 %. Only 15 couples had HPV genotype-specific concordance (oral-oral n = 7; male oral-female genital n = 9; female oral-male genital n = 2). In the nested case–control setting, higher number of deliveries (OR 0.145, 95%CI 0.030–0.706, p = 0.017) and higher number of intercourse (OR 0.488, 95%CI 0.243–0.978, p = 0.043) decreased the likelihood of concordant HPV infections while practicing oral sex increased the risk (OR 0.299, 95%CI 0.120–0.748, p = 0.010). In multivariate analysis, the likelihood of concordance was decreased by higher number of pregnancies of the female partner (p = 0.020) and by higher frequency of intercourse reported by the male spouse (p = 0.027). To conclude, asymptomatic HPV infections were common in both spouses while genotype-specific concordance was low. This supports the view that HPV profile of the spouses has been established before the current marital relationship.

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Acknowledgments

The Finnish Family HPV Study has been supported by the Academy of Finland, Finnish Cancer Foundation, Sohlberg Foundation, the Government Special Foundation (EVO) to Turku University Hospital and Finnish Dental Society Apollonia. The authors would like to thank Dr. Marjut Rintala and midwife Elisa Hovimäki for participating in the enrolment of the women in the Finnish Family HPV Study and their clinical follow-up. The skilful technical assistance of Mrs. Tatjana Peskova, Mariia Henttinen and Keitlin Adel is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, P.O. Box 52, 20521, Turku, Finland

    K. Kero, K. Louvanto & S. Grenman

  2. MediCity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, Department of Pathology, Turku University Hospital, University of Turku, Turku, Finland

    J. Rautava & S. Syrjänen

  3. Clinical Research, Biohit Oyj, Helsinki, Finland

    K. Syrjänen

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  1. K. Kero
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  2. J. Rautava
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  3. K. Louvanto
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  4. K. Syrjänen
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  5. S. Grenman
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  6. S. Syrjänen
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Correspondence to K. Kero.

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None of the authors have any conflicts of interest with regard to the Finnish Family HPV-Study.

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Kero, K., Rautava, J., Louvanto, K. et al. Genotype-specific concordance of oral and genital human papillomavirus infections among marital couples is low. Eur J Clin Microbiol Infect Dis 35, 697–704 (2016). https://doi.org/10.1007/s10096-016-2589-9

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  • DOI: https://doi.org/10.1007/s10096-016-2589-9

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