Alzheimer’s disease and disseminated mycoses

Article

DOI: 10.1007/s10096-013-2045-z

Cite this article as:
Alonso, R., Pisa, D., Rábano, A. et al. Eur J Clin Microbiol Infect Dis (2014) 33: 1125. doi:10.1007/s10096-013-2045-z

Abstract

Alzheimer’s disease (AD) is characterized by the presence in the brain of amyloid plaques and neurofibrillary tangles that provoke neuronal cell death, vascular dysfunction and inflammatory processes. In the present work, we have analyzed the existence of fungal infection in AD patients. A number of tests have been carried out in blood serum, including the detection of antibodies against several yeast species and fungal proteins, and also the presence of fungal (1,3)-β-glucan. Results from this analysis indicate that there is disseminated fungal infection in the majority of AD patients tested. Of interest, several AD patients contain high levels of fungal polysaccharides in peripheral blood, reflecting that disseminated fungal infection occurs in these patients. Together, these results suggest the presence of disseminated mycoses in blood serum from AD patients. To our knowledge these findings represent the first evidence that fungal infection is detectable in blood samples in AD patients. The possibility that this may represent a risk factor or may contribute to the etiological cause of AD is discussed.

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Centro de Biología Molecular Severo Ochoa CSIC-UAMUniversidad Autónoma de MadridMadridSpain
  2. 2.Department of Neuropathology and Tissue Bank, Unidad de Investigación Proyecto Alzheimer, Fundación CIENInstituto de Salud Carlos IIIMadridSpain

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