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Alarming incidence of genital mycoplasmas among HIV-1-infected MSM in Jiangsu, China

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Abstract

Males who have sex with men (MSM) are considered at high risk of blood-borne and sexually transmitted infections (STIs), mainly due to the practice of unsafe sex, often combined with drug use and needle-sharing. A cross-sectional study was designed for the detection of genital mycoplasmas during the period from March 2009 to May 2010 in Jiangsu province. This work was approved by the Research ethics Committee of Jiangsu Centers for Diseases Prevention and Control (CDC), and written consent was obtained from all participants. In total, 243 human immunodeficiency virus-1 (HIV-1)-infected MSM were screened in this study. Over half of them reported a history of sexual activity with females (65.0 %), and 26.3 % reported a history of sexually transmitted diseases (STDs) other than HIV. 44.0 % of patients were in the first 2 years of their HIV infection, and 72.4 % were still in HIV progression. Of the 243 analyzed samples, all were positive for at least one kind of mycoplasma. The infection rates of Mycoplasma genitalium, M. fermentans, M. penetrans, and M. pirum were 25.5, 9.9, 2.5, and 18.5 %, respectively. The M. genitalium infection was associated with a history of sexual activity with females, and those who had sex with females showed higher infection rates. Six  M. penetrans-positive patients were still in HIV infection progression and did not receive highly active antiretroviral therapy (HAART). Men who perform this particular behavior are at higher risk of Mycoplasma infections. Further molecular and epidemiological cohort studies with larger populations are needed in order to identify the role of Mycoplasma infections in HIV-1-infected MSM.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Project No. 30872156) and the Fundamental Research Funds for the Central Universities (Project No. CXZZ12_0121). The assistance of the STD and AIDS Department of the Jiangsu Province CDC was gratefully acknowledged.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, People’s Republic of China

    J.-R. Wu, B. Wang, L.-S. Chen, T. Yang, L.-J. Zhou & Y.-X Xie

  2. Department of Epidemiology and Statistics, School of Public Health, Southeast University, Nanjing, Jiangsu, People’s Republic of China

    J.-R. Wu, B. Wang, L.-S. Chen, T. Yang, L.-J. Zhou & Y.-X Xie

  3. Jiangsu Centers for Diseases Prevention and Control, Nanjing, Jiangsu, 210009, People’s Republic of China

    J.-S. Xu, H.-X. Guo & X.-P. Huan

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  1. J.-R. Wu
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  2. B. Wang
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  3. L.-S. Chen
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  4. T. Yang
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  7. J.-S. Xu
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  9. X.-P. Huan
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Correspondence to B. Wang.

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Wu, JR., Wang, B., Chen, LS. et al. Alarming incidence of genital mycoplasmas among HIV-1-infected MSM in Jiangsu, China. Eur J Clin Microbiol Infect Dis 33, 189–195 (2014). https://doi.org/10.1007/s10096-013-1942-5

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  • DOI: https://doi.org/10.1007/s10096-013-1942-5

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