Recurrent cellulitis with benzathine penicillin prophylaxis is associated with diabetes and psoriasis

  • M. KarppelinEmail author
  • T. Siljander
  • H. Huhtala
  • A. Aromaa
  • J. Vuopio
  • K. Hannula-Jouppi
  • J. Kere
  • J. Syrjänen


Risk factors for recurrent cellulitis were assessed in a case–control study including 398 patients receiving prophylactic treatment with benzathine penicillin and 8,005 controls derived from a national population-based health survey. In the multivariate analysis, psoriasis [odds ratio (OR) 3.69], other chronic dermatoses (OR 4.14), diabetes (OR 1.65), increasing body mass index (OR 1.17), increasing age (OR 1.06) and history of previous tonsillectomy (OR 6.82) were independently associated with recurrent cellulitis. Forty percent of the patients reported a cellulitis recurrence, despite ongoing benzathine penicillin prophylaxis. The role of previous tonsillectomy in recurrent cellulitis needs further evaluation.


Psoriasis Cellulitis Erysipelas Benzathine Penicillin National Public Health Institute 
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Ms. Päivi Aitos, Ms. Henna Degerlund and Mr. Hannu Turunen are warmly thanked for their technical assistance.

Financial support

This study was supported by grants from the Academy of Finland/MICMAN Research Programme 2003–2005 and the Competitive Research Funding of the Pirkanmaa Hospital District, Tampere University Hospital, Tampere, Finland.

Potential conflicts of interest

All authors: no conflicts.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • M. Karppelin
    • 1
    Email author
  • T. Siljander
    • 2
  • H. Huhtala
    • 3
  • A. Aromaa
    • 4
  • J. Vuopio
    • 2
  • K. Hannula-Jouppi
    • 5
  • J. Kere
    • 5
    • 6
  • J. Syrjänen
    • 1
    • 7
  1. 1.Department of Internal MedicineTampere University HospitalTampereFinland
  2. 2.Bacteriology UnitNational Institute for Health and WelfareHelsinkiFinland
  3. 3.School of Public HealthUniversity of TampereTampereFinland
  4. 4.National Institute for Health and WelfareHelsinkiFinland
  5. 5.Department of Medical GeneticsUniversity of HelsinkiHelsinkiFinland
  6. 6.Department of Biosciences and Nutrition, and Clinical Research CenterKarolinska InstitutetHuddingeSweden
  7. 7.Medical SchoolUniversity of TampereTampereFinland

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