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Biliary tract infections caused by Aeromonas species

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Abstract

This study investigated the clinical and microbiological characteristics of patients with Aeromonas infections of the biliary tract. Patients with bile cultures positive for Aeromonas species during the period July 2004 to December 2011 were identified from a computerized database of a hospital in Taiwan. Patients with Aeromonas infections of the biliary tract were further identified. During the study period, a total of 1,142 isolates of Aeromonas species were obtained from 750 patients. Of those patients, 91 (12.1 %) had Aeromonas infections of the biliary tract. The annual incidence (episodes per 10,000 patient-days) of biliary tract infections caused by all Aeromonas species was 0.31 in 2007, 0.12 in 2010, and 0.27 in 2011. A. hydrophila was the most common species isolated (n = 41, 45.1 %), followed by A. caviae (n = 30, 33.0 %), A. veronii biovar sobria (n = 15, 16.5 %), and A. veronii biovar veronii (n = 5, 5.5 %). The majority of patients (n = 77, 84.6 %) had polymicrobial infections. Hepatobiliary stones (n = 50, 54.9 %) and hepatobiliary cancer (n = 38, 41.8 %) were the most common underlying diseases, followed by diabetes mellitus (n = 29, 31.9 %) and liver cirrhosis (n = 7, 7.7 %). The in-hospital mortality rate was 8.8 %. Infection-related mortality was associated with underlying immunocompromised condition (p = 0.044) and use of mechanical ventilation (p = 0.004), but was not associated with inappropriate antibiotic usage or concomitant bacteremia (n = 8, 8.8 %). In conclusion, biliary tract infections caused by Aeromonas species are not uncommon and can develop in both immunocompromised and immunocompetent patients; however, patients with underlying hepatobiliary diseases are particularly susceptible to these infections.

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Authors and Affiliations

  1. Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan, Taiwan

    C. M. Chao & C. C. Lai

  2. Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan

    H. J. Tang

  3. Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan

    H. J. Tang

  4. Department of Internal Medicine and Center for Infection Control, National Cheng Kung University Hospital, Tainan, Taiwan

    W. C. Ko

  5. Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan

    W. C. Ko

  6. Departments of Laboratory and Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan

    P.-R. Hsueh

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  1. C. M. Chao
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  2. C. C. Lai
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  3. H. J. Tang
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  4. W. C. Ko
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  5. P.-R. Hsueh
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Correspondence to P.-R. Hsueh.

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Chao, C.M., Lai, C.C., Tang, H.J. et al. Biliary tract infections caused by Aeromonas species. Eur J Clin Microbiol Infect Dis 32, 245–251 (2013). https://doi.org/10.1007/s10096-012-1736-1

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  • DOI: https://doi.org/10.1007/s10096-012-1736-1

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