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Association of polymorphism +874 A/T of interferon-γ and susceptibility to the development of tuberculosis: meta-analysis

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Abstract

The immune defence against Mycobacterium tuberculosis is complex and involves multiple interacting cells. Studies in subjects with polymorphisms in genes for IFN or its receptor gene evaluate their relationship with mycobacterium infections. The purpose of this study was to analyze the evidence of the effect of polymorphism +874 A/T from interferon-γ on the occurrence of tuberculosis. We performed a meta-analysis of studies published between June 2002 and April 2012. The articles analyzed assessed the relationship between the polymorphism +874 A/T and the development of tuberculosis. The meta-analysis was performed with a random effect model, considering the heterogeneity among studies. Genotype TT showed a protective effect (OR, 0.77; 95% CI = 0.67–0.88) while genotype AA may be associated with increased susceptibility to developing tuberculosis (OR, 1.51; 95% CI = 1.38–1.65). In relation to alleles, we can verify that the A allele is related to the development of tuberculosis (OR, 1.56; 95% CI = 1.42–1.71). This information reinforces the importance of host genetics in the development of infectious diseases. Studies in this area can result in the promotion of new and more accurate genetic markers.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Research Laboratory of Applied Microbiology, Federal University of Ceará, Ceará, Fortaleza, Brazil

    A. C. de Albuquerque, L. Q. Rocha, A. H. de Morais Batista, A. B. Teixeira & N. A. P. Nogueira

  2. Center for Health Sciences, Federal Universityof Recôncavo da Bahia, Santo Antônio de Jesus, Salvador, Bahia, Brazil

    D. B. dos Santos

  3. Department of Clinical and Toxicological Analysis, Federal University of Ceará, Capitão Francisco Pedro, 1210—Porangabussu, Fortaleza, Ceará, Brazil

    A. C. de Albuquerque

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  1. A. C. de Albuquerque
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  2. L. Q. Rocha
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Correspondence to A. C. de Albuquerque.

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de Albuquerque, A.C., Rocha, L.Q., de Morais Batista, A.H. et al. Association of polymorphism +874 A/T of interferon-γ and susceptibility to the development of tuberculosis: meta-analysis. Eur J Clin Microbiol Infect Dis 31, 2887–2895 (2012). https://doi.org/10.1007/s10096-012-1660-4

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