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Outpatient parenteral antibiotic therapy (OPAT) at home in Attica, Greece

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Abstract

Outpatient parenteral antibiotic therapy (OPAT) is considered to be a cost-effective and safe alternative treatment strategy to hospitalization. We retrospectively evaluated data regarding the demographic and treatment characteristics of patients that sought medical advice from a network of physicians performing house-call visits and who received OPAT at home during a 17-month period (May 2009 to September 2010) in Attica, Greece. A total of 91 patients (69.2 % females) received intravenous antibiotic therapy at home during the evaluated period. The mean age [± standard deviation (SD)] of the patients was 85.3 (± 9) years. The main indications were pneumonia [46 patients (50.5 %)], urinary tract infection [25 (27.5 %)], and gastrointestinal tract infection [9 (9.9 %)]. Of the patients, 76.4 % received a beta-lactam, 17.5 % a fluoroquinolone, 15.3 % an imidazole, 8.7 % an aminoglycoside, and 5.4 % a lincosamide. The cure rate was 72.5 % and mortality was 27.5 %. The mean duration (± SD) of intravenous antibiotic treatment was 4.7 (± 3.3) days. The mean cost per patient was €637 and was comparable to the mean cost if the patient were to be hospitalized for the same infection. There was significant clinical effectiveness of OPAT at home in this mainly elderly population, at an acceptable cost.

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References

  1. Paladino JA, Poretz D (2010) Outpatient parenteral antimicrobial therapy today. Clin Infect Dis 51(Suppl 2):S198–S208

    Article  PubMed  Google Scholar 

  2. Ross Nolet B (2010) Update and overview of outpatient parenteral antimicrobial therapy regulations and reimbursement. Clin Infect Dis 51(Suppl 2):S216–S219

    Article  PubMed  Google Scholar 

  3. Chapman AL, Dixon S, Andrews D, Lillie PJ, Bazaz R, Patchett JD (2009) Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy (OPAT): a UK perspective. J Antimicrob Chemother 64:1316–1324

    Article  PubMed  CAS  Google Scholar 

  4. Nathwani D (2009) Developments in outpatient parenteral antimicrobial therapy (OPAT) for Gram-positive infections in Europe, and the potential impact of daptomycin. J Antimicrob Chemother 64:447–453

    Article  PubMed  CAS  Google Scholar 

  5. Skoutelis A, Petrochilos J, Bassaris H (1994) Successful treatment of thoracic actinomycosis with ceftriaxone. Clin Infect Dis 19:161–162

    Article  PubMed  CAS  Google Scholar 

  6. Karachalios GN, Georgiopoulos AN, Kanatakis S (1989) Treatment of various infections in an outpatient practice by intramuscular ceftriaxone: home parenteral therapy. Chemotherapy 35:389–392

    Article  PubMed  CAS  Google Scholar 

  7. Carratalà J, Fernández-Sabé N, Ortega L, Castellsagué X, Rosón B, Dorca J, Fernández-Agüera A, Verdaguer R, Martínez J, Manresa F, Gudiol F (2005) Outpatient care compared with hospitalization for community-acquired pneumonia: a randomized trial in low-risk patients. Ann Intern Med 142(3):165–172

    PubMed  Google Scholar 

  8. Ingram PR, Cerbe L, Hassell M, Wilson M, Dyer JR (2008) Limited role for outpatient parenteral antibiotic therapy for community-acquired pneumonia. Respirology 13:893–896

    Article  PubMed  Google Scholar 

  9. Esposito S, Leone S, Noviello S, Ianniello F, Russo M, Foti G, Carpentieri MS, Cellesi C, Zanelli G, Cellini A, Girmenia C, De Lalla F, Maiello A, Maio P, Acone N, Marranconi F, Sabbatani S, Pantaleoni M, Ghinelli F, Soranzo ML, Viganò P, Re T, Viale P, Scudeller L; Registro Nazionale OPAT (2009) Outpatient parenteral antibiotic therapy in the elderly: an Italian observational multicenter study. J Chemother 21:193–198

    PubMed  CAS  Google Scholar 

  10. Athanassa Z, Makris G, Dimopoulos G, Falagas ME (2008) Early switch to oral treatment in patients with moderate to severe community-acquired pneumonia: a meta-analysis. Drugs 68:2469–2481

    Article  PubMed  CAS  Google Scholar 

  11. Shepperd S, Doll H, Angus RM, Clarke MJ, Iliffe S, Kalra L, Ricauda NA, Tibaldi V, Wilson AD (2009) Avoiding hospital admission through provision of hospital care at home: a systematic review and meta-analysis of individual patient data. CMAJ 180:175–182

    Article  PubMed  Google Scholar 

  12. Gilchrist M, Franklin BD, Patel JP (2008) An outpatient parenteral antibiotic therapy (OPAT) map to identify risks associated with an OPAT service. J Antimicrob Chemother 62:177–183

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. SOS Doctors, 1 Ipirou Street, Athens, 10433, Greece

    G. Theocharis, D. Rodis & S. G. Barbas

  2. Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, 151 23, Marousi, Athens, Greece

    P. I. Rafailidis, I. Kontopidis & M. E. Falagas

  3. Department of Medicine, Henry Dunant Hospital, Athens, Greece

    M. E. Falagas

  4. Department of Medicine, Tufts University School of Medicine, Boston, MA, USA

    M. E. Falagas

Authors
  1. G. Theocharis
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  2. P. I. Rafailidis
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  3. D. Rodis
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  4. I. Kontopidis
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  5. S. G. Barbas
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  6. M. E. Falagas
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Correspondence to M. E. Falagas.

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Theocharis, G., Rafailidis, P.I., Rodis, D. et al. Outpatient parenteral antibiotic therapy (OPAT) at home in Attica, Greece. Eur J Clin Microbiol Infect Dis 31, 2957–2961 (2012). https://doi.org/10.1007/s10096-012-1647-1

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  • DOI: https://doi.org/10.1007/s10096-012-1647-1

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