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Prevention of group B streptococcal neonatal disease revisited. The DEVANI European project

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Abstract

The purpose of this paper was to present the current knowledge on the prevention of group B streptococcus (GBS) neonatal infections and the status of prevention policies in European countries and to present the DEVANI pan-European program, launched in 2008. The aim of this program was to assess the GBS neonatal infection burden in Europe, to design a new vaccine to immunize neonates against GBS infections, to improve the laboratory performance for the diagnosis of GBS colonization and infection, and to improve the methods for the typing of GBS strains. The current guidelines for GBS prevention in different countries were ascertained and a picture of the burden before and after the instauration of prevention policies has been drawn. After the issue of the Centers for Disease Control and Prevention (CDC) guidelines, many European countries have adopted universal screening for the GBS colonization of pregnant women and intrapartum prophylaxis to colonized mothers. Nevertheless, some European countries continue advocating the risk factor approach to GBS prevention. Most European countries have implemented policies to prevent GBS neonatal infections and the burden of the disease has decreased during the last several years. Nevertheless, further steps are necessary in order to develop new strategies of prevention, to improve microbiological techniques to detect GBS colonization and infection, and to coordinate the prevention policies in the EU.

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Acknowledgments

The DEVANI consortium is funded by European Commission (EC) in the frame of the Seventh Framework Programme (FP7), HEALTH-F5-2007-200481.

The researchers are not dependent on the founder.

Author information

Authors and Affiliations

  1. Microbiology, University Hospital Virgen de las Nieves, La Caleta, Granada, 18014, Spain

    J. Rodriguez-Granger, J. C. Alvargonzalez & M. Rosa-Fraile

  2. Unita Operativa di Terapia Intensiva Neonatale, Azienda Ospedaliero—Universitaria Policlinico di Modena, Modena, Italy

    A. Berardi

  3. Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany

    R. Berner & M. Hufnagel

  4. Department of Gynecology and Obstetrics, University Medical Center Freiburg, Freiburg, Germany

    M. Kunze

  5. Medical Microbiology Department, Centre Hospitalier Universitaire de Liège, Liège, Belgium

    P. Melin

  6. National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria

    A. Decheva

  7. Istituto Superiore di Sanità, Rome, Italy

    G. Orefici & L. Baldassarri

  8. Centre National de Référence des Streptocoques, APHP Hôpital COCHIN, Université Paris Descartes, Paris, France

    C. Poyart

  9. Novartis Vaccines and Diagnostics, Siena, Italy

    J. Telford

  10. Respiratory and Systemic Infection Laboratory, Health Protection Agency, Microbiology Services Division Colindale, London, UK

    A. Efstratiou

  11. Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark

    M. Killian

  12. National Institute of Public Health, Prague, Czech Republic

    P. Krizova

  13. Institute of Medical Microbiology and Hygiene, University of Ulm, Ulm, Germany

    B. Spellerberg

  14. Gynecology and Obstetrics, University Hospital Virgen de las Nieves, Granada, Spain

    A. Puertas

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Correspondence to J. Rodriguez-Granger.

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Rodriguez-Granger, J., Alvargonzalez, J.C., Berardi, A. et al. Prevention of group B streptococcal neonatal disease revisited. The DEVANI European project. Eur J Clin Microbiol Infect Dis 31, 2097–2104 (2012). https://doi.org/10.1007/s10096-012-1559-0

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