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Invasive pulmonary aspergillosis in patients with HBV-related liver failure

European Journal of Clinical Microbiology & Infectious Diseases volume 30, pages 661–667 (2011)Cite this article

Abstract

Invasive pulmonary aspergillosis (IPA) has been increasingly frequent in severe liver disease. We aim to investigate the clinical presentation, predisposing factors, and treatment of IPA in patients with liver failure caused by hepatitis B virus (HBV) infection. Medical records from 798 patients with HBV-related liver failure were reviewed. A total of 43 patients with probable IPA were selected as the case group, another 43 patients with bacterial infection and 43 patients without any infections were selected, for whose age, sex, date of admission, and the disease onset were matched with the case group. We evaluated the risk factors, clinical manifestations, treatment, and subsequent outcome of IPA in patients with HBV-related liver failure. Multivariate logistic regression models were used to demonstrate risk factors associated with IPA. Compared with patients with bacterial infection and those without any infection, patients with probable IPA used more antibiotics and steroids, and had poorer conditions and the highest mortality (P < 0.0001). Multiple antibiotics use and frequent invasive procedures were independent factors associated with the occurrence of IPA in patients with HBV-related liver failure. Patients with HBV-related liver failure are predisposed to IPA and may have a more severe condition and poorer prognosis.

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Acknowledgments

This work was supported by the Tracking Project of Medical Applicable Technology of Health Bureau of Hebei Province (No. GL200805). We would like to thank Shijiazhuang Fifth Hospital for sharing their clinical database of HBV-related liver failure.

Competing interests

The authors declare that they have no competing interests.

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  1. Department of Infectious Disease, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, 050051, China

    W. Wang, C. Y. Zhao, J. Y. Zhou, Y. D. Wang, C. Shen, D. F. Zhou & H. Z. Yin

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  1. W. Wang
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  2. C. Y. Zhao
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  3. J. Y. Zhou
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  4. Y. D. Wang
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  5. C. Shen
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  6. D. F. Zhou
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  7. H. Z. Yin
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Correspondence to C. Y. Zhao.

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Wang, W., Zhao, C.Y., Zhou, J.Y. et al. Invasive pulmonary aspergillosis in patients with HBV-related liver failure. Eur J Clin Microbiol Infect Dis 30, 661–667 (2011). https://doi.org/10.1007/s10096-010-1137-2

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  • DOI: https://doi.org/10.1007/s10096-010-1137-2

Keywords

  • Liver Failure
  • Voriconazole
  • Caspofungin
  • Invasive Pulmonary Aspergillosis
  • Aspergillus Infection