Skip to main content
SpringerLink
Log in

Local imipenem activity against Pseudomonas aeruginosa decreases in vivo in the presence of siliconized latex

  • Brief Report
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

Zinc eluted from siliconized latex (SL) increases resistance of Pseudomonas aeruginosa to imipenem in vitro. A foreign body peritonitis model was used to evaluate the activity of imipenem using SL or silicone (S) implants. No differences were observed in mortality, positive blood cultures and tissue bacterial counts between SL and S implants. Implant-associated counts, however, were significantly higher in the SL group. It is concluded that SL decreases the activity of imipenem against P. aeruginosa.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Martínez-Martínez L, Pascual A, Conejo MC, Picabea L, Perea EJ (1999) Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations. Antimicrob Agents Chemother 43:397–399

    PubMed  Google Scholar 

  2. Conejo MC, Martinez-Martinez L, Garcia I, Picabea L, Pascual A (2003) Effect of siliconized latex urinary catheters on the activity of carbapenems against Pseudomonas aeruginosa strains with defined mutations in ampC, oprD, and genes coding for efflux systems. Int J Antimicrob Agents 22:122–127

    Article  CAS  PubMed  Google Scholar 

  3. Espersen F, Fridmodt-Moller N (1999) Murine model of peritonitis involving a foreign body. In: Zak O, Sande MA (eds) Handbook of animal models of infection. Academics, London, pp 183–188

    Chapter  Google Scholar 

  4. Perron K, Caille O, Rossier C, Van Delden C, Dumas JL, Kohler T (2004) CzcR-CzcS, a two component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa. J Biol Chem 279:8761–8768

    Article  CAS  PubMed  Google Scholar 

  5. Conejo MC, Garcia I, Martinez-Martinez L, Picabea L, Pascual A (2003) Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 47:2313–2315

    Article  CAS  PubMed  Google Scholar 

  6. Hernández-Burruezo JJ, Omar Mohamed-Balghata M, Aliaga Martínez L, Sociedad Andaluza de Enfermedades Infecciosas (SAEI) (2007) Urinary tract infections. Med Clin (Barc) 129:707–715

    Article  Google Scholar 

  7. Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings SE, Rice JC et al (2010) Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 international clinical practice guidelines from the Infectious Diseases Society of America. Clin Infect Dis 50:625–663

    PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the Dirección General de Investigación del Ministerio de Ciencia y Tecnología, Spain (project SAF2003-01241) and by Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III, co-financed by European Development Regional Fund “A way to achieve Europe” ERDF, Spanish Network for the Research in Infectious Diseases (REIPI RD06/0008).

There are no conflicts of interest regarding this work.

Author information

Authors and Affiliations

  1. Infectious Diseases Service, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Avda. Manuel Siurot s/n, 41013, Seville, Spain

    C. Pichardo, F. Docobo-Pérez, R. López-Rojas, M. E. Pachón-Ibáñez & J. Pachón

  2. Department of Microbiology, School of Medicine, Sevilla, Spain

    M. C. Conejo, C. Velasco, I. García, J. M. Rodríguez & A. Pascual

Authors
  1. C. Pichardo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. C. Conejo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Docobo-Pérez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Velasco
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. López-Rojas
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. I. García
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. E. Pachón-Ibáñez
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. M. Rodríguez
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. J. Pachón
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A. Pascual
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to C. Pichardo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pichardo, C., Conejo, M.C., Docobo-Pérez, F. et al. Local imipenem activity against Pseudomonas aeruginosa decreases in vivo in the presence of siliconized latex. Eur J Clin Microbiol Infect Dis 30, 289–291 (2011). https://doi.org/10.1007/s10096-010-1084-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-010-1084-y

Keywords

Search

Navigation