Abstract
As part of the worldwide Study for Monitoring Antimicrobial Resistance Trends (SMART), a total of 3,030 clinical isolates of Gram-negative bacilli from intra-abdominal infections were collected from 43 hospital centres from 13 European countries during 2008. Of 51 species, the most commonly isolated species were Escherichia coli (49.3%), followed by Klebsiella pneumoniae (10.5%) and Pseudomonas aeruginosa (8.6%). Respectively, 17.9%, 11.6%, 5.5% and 4.5% of K. pneumoniae, E. coli, Proteus mirabilis and K. oxytoca were extended-spectrum beta-lactamase (ESBL)-positive. All isolates were tested using a panel of 12 antimicrobial agents, and susceptibilities were determined using European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints. The most active agents against the study isolates (including those producing ESBLs) were amikacin, ertapenem and imipenem. Overall, with the exception of the carbapenems, most agents exhibited dramatically reduced susceptibilities against ESBL-positive and multi-drug-resistant isolates.
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Acknowledgements
SH works for IHMA Europe, a wholly owned subsidiary of International Health Management Associates, Inc. (IHMA). DH, SB and RB all work for IHMA, Inc., which is paid to coordinate/manage the SMART programme. YC is part of Merck’s “Speaker Bureau”. PH has no conflicts.
Parts of this work were presented in Poster E-1477 at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2009), San Francisco, CA, September 2009 (“Global Susceptibility Patterns of E. coli from Intra-Abdominal Infections to Ertapenem and Comparators—SMART 2008”).
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Hawser, S., Hoban, D., Bouchillon, S. et al. Antimicrobial susceptibility of intra-abdominal Gram-negative bacilli from Europe: SMART Europe 2008. Eur J Clin Microbiol Infect Dis 30, 173–179 (2011). https://doi.org/10.1007/s10096-010-1066-0
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DOI: https://doi.org/10.1007/s10096-010-1066-0