Abstract
In the present retrospective study, we described a series of 45 non-icteric leptospirosis and 44 nephropathia epidemica (NE) patients diagnosed in the northeast of France from 1995 to 2005 and compared their clinical picture and laboratory parameters, as well as some epidemiological data. Loin pain (P < 0.001), abdominal pains (P = 0.007), rise of blood pressure (P < 0.001) and pharyngitis (P = 0.01) were more frequently found in NE patients. Aspartate aminotransferase (ASAT) (P = 0,006), creatine phosphokinase (CPK) (P < 0.0001) and C-reactive protein (CRP) (P < 0.0001) were higher in leptospirosis, whereas creatinine (P = 0.009) was higher in NE. Leptospirosis mainly concerns occupational hazards, e.g. farmers, and leisure activities like swimming, and NE concerns professional foresters or leisure activities in the forest and the cleaning of attics. During hospitalisation, patients receiving antibiotics were more frequent among leptospirosis than among NE patients (80% versus 59%, P = 0.06). Among the various common clinical signs, only acute myopia appeared to be a pathognomonic but inconsistently observed clinical sign, which was only observed in 47% of NE cases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Vapalahti O, Mustonen J, Lundkvist A, Henttonen H, Plyusnin A, Vaheri A (2003) Hantavirus infections in Europe. Lancet Infect Dis 3:653–661. doi:10.1016/S1473-3099(03)00774-6
Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA et al (2003) Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3:757–771. doi:10.1016/S1473-3099(03)00830-2
Pappas G, Papadimitriou P, Siozopoulou V, Christou L, Akritidis N (2008) The globalization of leptospirosis: worldwide incidence trends. Int J Infect Dis 12:351–357. doi:10.1016/j.ijid.2007.09.011
Heyman P, Cochez C, Ducoffre G, Mailles A, Zeller H, Abu Sin M et al (2007) Haemorrhagic fever with renal syndrome: an analysis of the outbreaks in Belgium, France, Germany, the Netherlands and Luxembourg in 2005. Euro Surveill 12:167–171. Available online at: http://www.eurosurveillance.org/em/v12n05/1205-228.asp
Janin C, Alsibaï S (2008) Survey on leptospirosis incidence in the Ardennes district, France, 1995–2005. Bull Epidem Hebd 19:164–167. Available online at: http://www.invs.sante.fr/beh/2008/19/beh_19_2008.pdf
Clement J, McKenna P, Colson P, Damoiseaux P, Penalba C, Halin P et al (1994) Hantavirus epidemic in Europe, 1993. Lancet 8:114. doi:10.1016/S0140-6736(94)90841-9
Strady C, Jaussaud R, Remy G, Penalba C (2005) Hantavirus infections. Presse Med 34:391–399
Farr RW (1995) Leptospirosis. Clin Infect Dis 21:1–8
Sion ML, Hatzitolios AI, Armenaka MC, Toulis EN, Kalampalika D, Mikoudi KD (2002) Acute renal failure caused by leptospirosis and Hantavirus infection in an urban hospital. Eur J Intern Med 13:264–268. doi:10.1016/S0953-6205(02)00037-7
Nardone A, Capek I, Baranton G, Campèse C, Postic D, Vaillant V et al (2004) Risk factors for leptospirosis in metropolitan France: results of a national case–control study, 1999–2000. Clin Infect Dis 39:751–753. doi:10.1086/423272
Van Loock F, Thomas I, Clement J, Ghoos S, Colson P (1999) A case–control study after a hantavirus infection outbreak in the south of Belgium: who is at risk? Clin Infect Dis 28:834–839. doi:10.1086/515196
Jauréguiberry S, Roussel M, Brinchault-Rabin G, Gacouin A, Le Meur A, Arvieux C et al (2005) Clinical presentation of leptospirosis: a retrospective study of 34 patients admitted to a single institution in metropolitan France. Clin Microbiol Infect 11:391–394. doi:10.1111/j.1469-0691.2005.01148.x
Baranton G, Postic D (2006) Trends in leptospirosis epidemiology in France. Sixty-six years of passive serological surveillance from 1920 to 2003. Int J Infect Dis 10:162–170. doi:10.1016/j.ijid.2005.02.010
Sauvage F, Penalba C, Vuillaume P, Boue F, Coudrier D, Pontier D et al (2002) Puumala hantavirus infection in humans and in the reservoir host, Ardennes region, France. Emerg Infect Dis 8:1509–1511
Bajani MD, Ashford DA, Bragg SL, Woods CW, Aye T, Spiegel RA et al (2003) Evaluation of four commercially available rapid serologic tests for diagnosis of leptospirosis. J Clin Microbiol 41:803–809. doi:10.1128/JCM.41.2.803-809.2003
Hujakka H, Koistinen V, Eerikäinen P, Kuronen I, Mononen I, Parviainen M et al (2001) New immunochromatographic rapid test for diagnosis of acute Puumala virus infection. J Clin Microbiol 39:2146–2150. doi:10.1128/JCM.39.6.2146-2150.2001
Evander M, Eriksson I, Pettersson L, Juto P, Ahlm C, Olsson GE et al (2007) Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome. J Clin Microbiol 45:2491–2497. doi:10.1128/JCM.01902-06
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Strady, C., Penalba, C., Baumard, S. et al. Nephropathia epidemica and leptospirosis in Champagne-Ardenne, France: comparison of clinical, biological and epidemiological profiles. Eur J Clin Microbiol Infect Dis 28, 825–829 (2009). https://doi.org/10.1007/s10096-009-0716-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-009-0716-6