References
Onishi H, Suzuki T (1968) Production of D-mannitol and glycerol by yeasts. Appl Microbiol 16(12):1847–1852
Chaturvedi V, Flynn T, Niehaus WG, Wong B (1996) Stress tolerance and pathogenic potential of a mannitol mutant of Cryptococcus neoformans. Microbiology 142(Pt 4):937–943
Chaturvedi V, Wong B, Newman SL (1996) Oxidative killing of Cryptococcus neoformans by human neutrophils. Evidence that fungal mannitol protects by scavenging reactive oxygen intermediates. J Immunol 156(10):3836–3840
Wong B, Perfect JR, Beggs S, Wright KA (1990) Production of the hexitol D-mannitol by Cryptococcus neoformans in vitro and in rabbits with experimental meningitis. Infect Immun 58(6):1664–1670
Megson GM, Stevens DA, Hamilton JR, Denning DW (1996) D-mannitol in cerebrospinal fluid of patients with AIDS and cryptococcal meningitis. J Clin Microbiol 34(1):218–221
Niehaus WG, Flynn T (1994) Regulation of mannitol biosynthesis and degradation by Cryptococcus neoformans. J Bacteriol 176(3):651–655
Yeo SF, Wong B (2002) Current status of nonculture methods for diagnosis of invasive fungal infections. Clin Microbiol Rev 15(3):465–484
Acknowledgements
The authors thank Anne Bartiss for her technical support in performing the mannitol measurements by gas–liquid chromatography and Dr. Otto Leiti, Dr. John Keiser and Raphael Yankey for their support in the collection of clinical samples.
This study was approved by the Institutional Review Boards at both. The George Washington University Medical Center and the Veterans Affairs Medical Center in Washington, DC, and the Research and Development Committee of the Veterans Affairs Medical Center in Washington, DC.
The views expressed in this article are those of the authors and do not reflect the policies of the Department of Veterans Affairs or The George Washington University. All authors report no conflicts of interest.
The results of this study were presented at the 45th Interscience Conference on Antimicrobial Agents and Chemotherapy in Washington, DC, during 16–19 December 2005.
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Liappis, A.P., Kan, V.L., Richman, N.C. et al. Mannitol and inflammatory markers in the cerebral spinal fluid of HIV-infected patients with cryptococcal meningitis. Eur J Clin Microbiol Infect Dis 27, 477–479 (2008). https://doi.org/10.1007/s10096-008-0462-1
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DOI: https://doi.org/10.1007/s10096-008-0462-1