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No influence of atopic diseases on antibody titres following tetanus, diphtheria and hepatitis B immunisation among adults

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Abstract

Several studies have reported associations between reduced humoral immune response to vaccine antigens and diseases with modified reactions of the immune system. We have investigated the influence of atopic diseases on specific IgG levels to tetanus, diphtheria and hepatitis B (HB), following immunisation, in a general adult population. From the Study of Health in Pomerania, a total number of 3,920 subjects aged 20 to 79 years were included in the analyses. Information on immunisation history, as well as behavioural and socio-demographic characteristics were collected. Anti-tetanus IgG, anti-diphtheria IgG and anti-HBs IgG were measured by indirect enzyme-linked immunosorbent assay (ELISA). Odds ratios and 95% confidence intervals were calculated using logistic regression. Atopic diseases were reported by 14% of participants. Proportions of 67%, 34% and 10% had been vaccinated against tetanus, diphtheria and hepatitis B within the past ten years, respectively. Multi-variable analyses revealed no associations between the presence of atopic diseases and all of the three vaccine-specific antibody titres. We conclude that there is no reduced immune response related to antibody production following immunisations against tetanus, diphtheria and hepatitis B in adults with atopic diseases.

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Acknowledgements

The Study of Health in Pomerania (SHIP) is part of the Community Medicine Net http://www.medizin.uni-greifswald.de/cm) of the University of Greifswald and is funded by grants from the German Federal Ministry of Education and Research (BMBF, grant no. 01ZZ); the Ministry for Education, Research and Cultural Affairs; and the Ministry for Social Affairs of the Federal State of Mecklenburg-West Pomerania. The contributions to the data collection made by field workers, study physicians, ultrasound technicians, interviewers and computer assistants are gratefully acknowledged.

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Authors and Affiliations

  1. Institute of Community Medicine, Ernst Moritz Arndt University of Greifswald, Walther-Rathenau-Str. 48, 17487, Greifswald, Germany

    N. Friedrich & H. Völzke

  2. Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University of Greifswald, Walther-Rathenau-Str. 48, 17487, Greifswald, Germany

    U. John

  3. Institute of Hygiene and Environmental Medicine, Ernst Moritz Arndt University of Greifswald, Walter-Rathenau-Str. 49A, 17487, Greifswald, Germany

    A. Kramer

  4. Institute of Microbiology, Ernst Moritz Arndt University of Greifswald, Martin-Luther-Str. 6, 17487, Greifswald, Germany

    R. Mentel & L. Gürtler

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  1. N. Friedrich
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Correspondence to N. Friedrich.

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Friedrich, N., Kramer, A., Mentel, R. et al. No influence of atopic diseases on antibody titres following tetanus, diphtheria and hepatitis B immunisation among adults. Eur J Clin Microbiol Infect Dis 26, 887–894 (2007). https://doi.org/10.1007/s10096-007-0374-5

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