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Decreasing gradient of antibiotic concentration in the lumen of catheters locked with vancomycin

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Abstract

The purpose of this study was to investigate if vancomycin concentration is maintained along the lumen of dialysis catheters after 48 h of lock therapy. Each lumen of nine catheters (three subclavian and six femoral) was locked with 2,500 mg/l of vancomycin for 48 h. After that period, the content of the lumen was aspirated with three different syringes of 0.4 ml each to measure the proximal, medial and distal vancomycin concentration. Vancomycin concentration was measured using a homogeneous particle-enhanced turbidimetric inhibition immunoassay. A non-parametric ANOVA, by means of a rank transformation on the antibiotic concentration, was used to assess the influence of the catheter segment (proximal, medial and distal) and the catheter type (femoral or subclavian). A significant decrease in vancomycin concentration from proximal to distal segments was observed (p < 0.001). In addition, the vancomycin concentration in subclavian catheters was significantly higher than in femoral catheters (p < 0.001). In our study there was a decreasing gradient in vancomycin concentration from proximal to distal segments of the catheter. This may explain the failure of antibiotic lock-therapy.

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Authors and Affiliations

  1. Department of Infectious Diseases, Hospital Clínic of Barcelona, C/ Villarroel 170, Barcelona, 08036, Spain

    A. Soriano, M. Ortega, J. A. Martínez & J. Mensa

  2. Department of Nephrology, Hospital Clínic of Barcelona, Barcelona, Spain

    E. Bregada

  3. Centre of biochemical diagnosis, Hospital Clínic of Barcelona, Barcelona, Spain

    J. M. Marqués

  4. Department of Internal Medicine, Hospital Clínic of Barcelona, Barcelona, Spain

    A. Bové

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  1. A. Soriano
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  2. E. Bregada
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  3. J. M. Marqués
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  4. M. Ortega
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  5. A. Bové
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  6. J. A. Martínez
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  7. J. Mensa
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Correspondence to A. Soriano.

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Soriano, A., Bregada, E., Marqués, J.M. et al. Decreasing gradient of antibiotic concentration in the lumen of catheters locked with vancomycin. Eur J Clin Microbiol Infect Dis 26, 659–661 (2007). https://doi.org/10.1007/s10096-007-0356-7

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  • DOI: https://doi.org/10.1007/s10096-007-0356-7

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