Abstract
The aim of the present study was to evaluate whether soluble triggering receptor expressed on myeloid cells (sTREM-1) is present in the cerebrospinal fluid (CSF) of patients with acute meningitis and if its presence can predict bacterial infection. We found elevated levels of sTREM-1 in the CSF of seven of the nine (78%) patients with culture-positive specimens and in none of 12 (0%) patients with culture-negative specimens (sensitivity: 78%; specificity: 100%). The area under the receiver operating characteristic curve for sTREM-1 in the CSF as a predictor for bacterial meningitis was 0.889. This suggests that sTREM-1 is upregulated in the CSF of patients with bacterial meningitis with high specificity and that its presence can potentially assist clinicians in the diagnosis of bacterial meningitis.
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We thank Ms. Phyllis Curchack Kornspan for her secretarial and editing assistance.
This study was presented in part at the 46th ICAAC. September, 2006. San Francisco, USA.
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Bishara, J., Hadari, N., Shalita-Chesner, M. et al. Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults. Eur J Clin Microbiol Infect Dis 26, 647–650 (2007). https://doi.org/10.1007/s10096-007-0343-z
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DOI: https://doi.org/10.1007/s10096-007-0343-z