References
Santolaya ME, Cofre J, Beresi V (1994) C-reactive protein: a valuable aid for the management of febrile children with cancer and neutropenia. Clin Infect Dis 18:589–595
Fleischhack G, Kambeck I, Cipic D, Hasan C, Bode U (2000) Procalcitonin in paediatric cancer patients: its diagnostic relevance is superior to that of C-reactive protein, interleukin 6, interleukin 8, soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II. Br J Haematol 111:1093–1102
Stryjewski GR, Nylen ES, Bell MJ et al (2005) Interleukin-6, interleukin-8, and a rapid and sensitive assay for calcitonin precursors for the determination of bacterial sepsis in febrile neutropenic children. Pediatr Crit Care Med 6:129–135
Immunocompromised Host Society (1990) The design, analysis, and reporting of clinical trials on the empirical antibiotic management of the neutropenic patient. J Infect Dis 161:397–401
Hanley JA, McNeil BJ (1983) A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 148:839–843
Jimeno A, Garcia-Velasco A, de Val O et al (2004) Assessment of procalcitonin as a diagnostic and prognostic marker in patients with solid tumors and febrile neutropenia. Cancer 100:2462–2469
Von Lilienfeld-Toal M, Dietrich MP, Glasmacher A et al (2004) Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein. Eur J Clin Microbiol Infect Dis 23:539–544
Persson L, Engervall P, Magnuson A et al (2004) Use of inflammatory markers for early detection of bacteraemia in patients with febrile neutropenia. Scand J Infect Dis 36:365–371
Giamarellou H, Giamarellos-Bourboulis EJ, Repoussis P et al (2004) Potential use of procalcitonin as a diagnostic criterion in febrile neutropenia: experience from a multicentre study. Clin Microbiol Infect 10:628–633
Ciaccio M, Fugardi G, Titone L et al (2004) Procalcitonin levels in plasma in oncohaematologic patients with and without bacterial infections. Clin Chim Acta 340:149–152
de Bont ESJM, Kamps W, Vellenga E, Swaanenburg J (2000) Procalcitonin: a diagnostic marker of bacterial infection in neutropenic cancer patients with fever? Infection 28:398–400
Engel A, Mack E, Kern P, Kern WV (1998) An analysis of interleukin-8, interleukin-6 and C-reactive protein serum concentrations to predict fever, gram-negative bacteremia and complicated infection in neutropenic cancer patients. Infection 26:213–221
Acknowledgements
This study was partly supported by The Ministry of Education, Science and Sports, Republic of Slovenia, grant number J3-3482-0312-02. The authors would like to thank the staff at the University Medical Centre Ljubljana, Department of Pediatrics, Division of Oncology and Hematology for collecting blood and microbiology samples. The study was approved by the National Ethics Committee.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kitanovski, L., Jazbec, J., Hojker, S. et al. Diagnostic accuracy of procalcitonin and interleukin-6 values for predicting bacteremia and clinical sepsis in febrile neutropenic children with cancer. Eur J Clin Microbiol Infect Dis 25, 413–415 (2006). https://doi.org/10.1007/s10096-006-0143-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-006-0143-x