Abstract
In order to explore the clinical significance and risk factors for true bacteremia caused by coagulase-negative staphylococci (CNS) other than Staphylococcus epidermidis, a retrospective cohort study of 160 patients with at least one blood culture positive for non-epidermidis CNS was performed. True bacteremia was diagnosed in 32 (20%) of the patients. On multivariate analysis the following factors were associated with true bacteremia: (i) more than one positive blood culture, (ii) presence of a central venous catheter, and (iii) methicillin resistance. The results of this study indicate that non-epidermidis CNS can cause significant bloodstream infections.
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References
Kloos WE, Bannerman TL (1994) Update on clinical significance of coagulase-negative staphylococci. Clin Microbiol Rev 7:117–140
Rupp ME, Archer GL (1994) Coagulase-negative staphylococci: pathogens associated with medical progress. Clin Infect Dis 19:231–245
Martin MA, Pfaller MA, Wenzel RP (1989) Coagulase-negative staphylococcal bacteremia. Ann Intern Med 110:9–16
Kirchhoff LV, Sheagren JN (1985) Epidemiology and clinical significance of blood cultures positive for coagulase-negative staphylococcus. Infect Control 6:479–486
Kim SD, McDonald C, Jarvis WR et al (2000) Determining the significance of coagulase-negative staphylococci isolated from blood cultures at a community hospital: a role for species and strain identification. Infect Control Hosp Epidemiol 21:213–217
Herwaldt LA, Geiss M, Kao C et al (1996) The positive predictive value of isolating coagulase-negative staphylococci from blood cultures. Clin Infect Dis 22:14–20
Perl TM, Krüger WA, Houston A et al (1999) Investigation of suspected nosocomial clusters of Staphylococcus haemolyticus infections. Infect Control Hosp Epidemiol 20:128–131
Kamath U, Singer C, Isenberg HD (1992) Clinical significance of Staphylococcus warneri bacteremia. J Clin Microbiol 30:261–264
Patel R, Piper KE, Rouse MS (2000) Frequency of isolation of Staphylococcus lugdunensis among staphylococcal isolates causing endocarditis: a 20-year experience. J Clin Microbiol 38:4262–4263
National Committee for Clinical Laboratory Standards (2000) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A5. NCCLS, Wayne, PA
Garner JS, Jarvis WR, Emori TG et al (1988) CDC definitions for nosocomial infections. J Infect Control 16:128–140
Charlson ME, Pompei P, Ales KL et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383
Mirrett S, Weinstein MP, Reimer LG et al (2001) Relevance of the number of positive bottles in determining clinical significance of coagulase-negative staphylococci in blood cultures. J Clin Microbiol 39:3279–3281
Ponce de Leon S, Wenzel RP (1984) Hospital acquired-bloodstream infections with Staphylococcus epidermidis: review of 100 cases. Am J Med 77:639–644
Dominguez-de Villota E, Algora-Weber A, Millan I et al (1987) Early evaluation of coagulase-negative staphylococcus in blood samples of intensive care unit patients: a clinically uncertain judgment. Intensive Care Med 13:390–394
Acknowledgments
We would like to thank Megan O’Brien, for statistical advice. We are grateful to Chantelle Mitchell for her essential help in establishing the database.
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Ruhe, J., Menon, A., Mushatt, D. et al. Non-epidermidis coagulase-negative staphylococcal bacteremia: clinical predictors of true bacteremia. Eur J Clin Microbiol Infect Dis 23, 495–498 (2004). https://doi.org/10.1007/s10096-004-1134-4
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DOI: https://doi.org/10.1007/s10096-004-1134-4