Abstract
The objective of this study was to evaluate the outcome of treatment of culture-positive cases of tuberculosis registered in Archangel, Russia, in 1999, and to analyse the influence of Mycobacterium tuberculosis drug resistance on treatment outcome. The outcome of tuberculosis treatment was evaluated for 235 new and 61 previously treated culture-positive cases diagnosed in 1999. Of the 235 new cases, there were 150 (63.8%) cases of treatment completion, 20 (8.5%) cases of treatment failure, 29 (12.3%) cases of death during treatment, and 29 (12.3%) cases in which the patient failed to pick up medications for at least 2 consecutive months. The outcome in 7 (3%) cases was unknown, as the patients were transferred outside the oblast region. Among the 61 previously treated cases, the rate of treatment completion was low (26.2%), and rates of treatment failure (23%) and failure to pick up medications for at least 2 consecutive months (29.5%) were high. The relation between the susceptibility pattern of the infecting strain as determined by the Bactec method and tuberculosis treatment outcome was analysed for 76 patients. The majority (69%) of patients infected with drug-susceptible strains was cured. A large proportion (58.8%) of patients infected with Mycobacterium tuberculosis resistant to more than two drugs did not respond to treatment, i.e. the treatment failed or the patients died. The high rates of death (16.7%) and failure (66.7%) among patients infected with multidrug-resistant strains illustrate the negative impact of multidrug resistance on the outcome of tuberculosis treatment. Pan-resistance was significantly associated with treatment failure (P<0.001). The spread of resistant Mycobacterium tuberculosis has a serious negative impact on the outcome of tuberculosis treatment in Archangel, Russia.
Similar content being viewed by others
References
Perelman MI (2000) Tuberculosis in Russia. Int J Tuberc Lung Dis 4:1097–1103
Toungoussova OS, Caugant DA, Sandven P, Mariandyshev AO, Bjune G (2002) Drug resistance of Mycobacterium tuberculosis strains isolated from patients with pulmonary tuberculosis in the Archangels oblast, Russia. Int J Tuberc Lung Dis 6:406–414
WHO Geneva/IUATLD Paris (1998) Guidelines for surveillance of drug resistance in tuberculosis. Int J Tuberc Lung Dis 2:72–89
Espinal MA, Kim SJ, Suarez PG, Kam KM, Khomenko AG, Migliori GB, Baez J, Kochi A, Dye C, Raviglione MC (2000) Standard short-course chemotherapy for drug-resistant tuberculosis treatment outcomes in 6 countries. JAMA 283:2537–2545
Singla R, Al-Sharif N, Al-Sayegh MO, Osman MM, Shaikh MA (2002) Influence of anti-tuberculosis drug resistance on the treatment outcome of pulmonary tuberculosis patients receiving DOTS in Riyadh, Saudi Arabia. Int J Tuberc Lung Dis 6:585–591
Sevim T, Atac G, Gungor G, Torun T, Aksoy E, Gemci I, Tahaoglu K (2002) Treatment outcome of relapse and defaulter pulmonary tuberculosis patients. Int J Tuberc Lung Dis 6:320–325
Kim SJ, Bai GH, Hong YP (1997) Drug-resistant tuberculosis in Korea, 1994. Int J Tuberc Lung Dis 1:302–308
Flament-Saillour M, Robert J, Jarlier V, Grosset J (1999) Outcome of multi-drug-resistant tuberculosis in France: a nationwide case-control study. Am J Respir Crit Care Med 160:587–593
The World Bank (1993) Investing in health: world development report 1993. Oxford University Press, New York
World Health Organization, Communicable Diseases Programme (2000) Global tuberculosis control. WHO, Geneva, p 275
Blower SM, Daley CL (2002) Problems and solutions for the Stop TB partnership. Lancet Infect Dis 2:374–376
World Health Organization (2003) Treatment of tuberculosis: guidelines for national programmes. WHO, Geneva, p 112
Enarson DA, Rieder HL, Arnadottir T, Trebucq A (1996) Tuberculosis guide for low-income countries. International Union Against Tuberculosis and Lung Diseases, Paris, p 65
Mariandyshev AO, Nizovtseva NI, Dityatev VI (2001) Treatment of patients with tuberculosis. Programme of short-course chemotherapy. Northern State Medical University, Arkhangelsk, Russia, p 26
Inderlied CB, Pfyffer GE (2003) Susceptibility test methods: mycobacteria. In: Murray PR, Baron EJ, Pfaller MA, Jorgensen JH, Yolken RH (eds) Manual of clinical microbiology. American Society for Microbiology, Washington DC, pp 1149–1177
Pfaller MA (1994) Application of new technology to the detection, identification, and antimicrobial susceptibility testing of mycobacteria. Am J Clin Pathol 101:329–337
Siddiqi SH (1995) BACTEC 460 TB System. Product and procedure manual, revision. Becton Dickinson Microbiology Systems, Sparks, MD, USA
Centers for Disease Control and Prevention (2001) Evaluation of a directly observed therapy short-course strategy for treating tuberculosis in Orel oblast, Russian Federation, 1999–2000. Morb Mortal Wkly Rep 50:204–206
Centers for Disease Control and Prevention (2001) Tuberculosis treatment interruptions in Ivanovo oblast, Russian Federation, 1999. Morb Mortal Wkly Rep 50:201–204
Laszlo A, Rahman M, Espinal M, Raviglione M, and the WHO/IUATLD Network of Supranational Reference Laboratories (2002) Quality assurance programme for drug susceptibility testing of Mycobacterium tuberculosis in the WHO/IUATLD Supranational Reference Laboratory Network: five rounds of proficiency testing, 1994–1998. Int J Tuberc Lung Dis 6:748–756
Mitchison DA (1998) How drug resistance emerges as a result of poor compliance during short-course chemotherapy for tuberculosis. Int J Tuberc Lung Dis 2:10–15
Kruuner A, Pehme L, Ghebremichael S, Koivula T, Hoffner SE, Mikelsaar M (2002) Use of molecular techniques to distinguish between treatment failure and exogenous reinfection with Mycobacterium tuberculosis. Clin Infect Dis 35:146–155
Acknowledgements
We thank Elisabet Rønnild, Anne Klem, Solveig Undseth, Ann Christine Øvrevik, and Kjersti Haugum for skilful technical assistance and Angelina Zemtsovskaya for strain collection. Special gratitude goes to Einar Heldal and Knut Øvreberg for useful discussions and assistance in implementation of the DOTS programme in the Archangel oblast. Funding was provided by grant no. 49711 from the Norwegian Ministry of Health and Social Affairs to P.S. and by the Norwegian Research Council, grant no. 128083/730 to D.A.C. The present study complies with the current laws of Russia and Norway.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Toungoussova, O.S., Nizovtseva, N.I., Mariandyshev, A.O. et al. Impact of Drug-Resistant Mycobacterium tuberculosis on Treatment Outcome of Culture-Positive Cases of Tuberculosis in the Archangel Oblast, Russia, in 1999. Eur J Clin Microbiol Infect Dis 23, 174–179 (2004). https://doi.org/10.1007/s10096-003-1080-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-003-1080-6