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Imported Human Trichinellosis: Sequential IgG4 Antibody Response to Trichinella spiralis

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Abstract

Two out of five members of one household presented with clinical signs of trichinellosis after their return to the Netherlands. The family had consumed Trichinella-infected pork in Montenegro, formerly Yugoslavia. Serological tests were performed at 1, 2, 6, and 18 months after ingestion of the infected meat. Trichinella-specific IgM, IgG, and IgA antibodies measured in sera from symptomatic and asymptomatic patients remained positive up to 18 months after ingestion. The measured IgG4 antibody response directed to a 45 kDa Trichinella spiralis antigen also persisted 18 months after ingestion for three of the family members.

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Authors and Affiliations

  1. Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, Department of Parasitology and Mycology, National Institute of Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands

    E. Pinelli, M. Mommers & L. M. Kortbeek

  2. Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, Department of Molecular Diagnostics and Resistance, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands

    W. Homan

  3. Department of Internal Medicine, Westfries Gasthuis, Hoorn, The Netherlands

    T. van Maanen

Authors
  1. E. Pinelli
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  2. M. Mommers
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  3. W. Homan
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  4. T. van Maanen
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  5. L. M. Kortbeek
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Correspondence to E. Pinelli.

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Pinelli, E., Mommers, M., Homan, W. et al. Imported Human Trichinellosis: Sequential IgG4 Antibody Response to Trichinella spiralis . Eur J Clin Microbiol Infect Dis 23, 57–60 (2004). https://doi.org/10.1007/s10096-003-1039-7

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  • DOI: https://doi.org/10.1007/s10096-003-1039-7

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