Two Unusual Cases of Diffuse Acrodermatitis Chronica Atrophicans Seronegative for Lyme Borreliosis

  • T. G. Berger
  • C. Schoerner
  • H. Schell
  • M. SimonJr
  • G. Schuler
  • M. Röllinghoff
  • A. GessnerEmail author
Brief Report

Acrodermatitis chronica atrophicans (ACA) is a late cutaneous manifestation of Lyme borreliosis [1]. In this stage of disease, serum IgG-antibodies against Borrelia burgdorferi have been detected in practically all patients examined so far [2, 3, 4]. Reported here are the cases of two patients with unusual manifestations of ACA. The histopathological pattern was consistent with ACA in both cases, but repeated serological examinations for antibodies against Borrelia burgdorferi were negative. The diagnosis was only confirmed in both cases by the detection of Borrelia burgdorferi-specific DNA using nested PCR and subsequent sequencing of the products.

ACA occurs in Europe in up to 10% of patients with untreated infection with Borrelia spp. [5], but it is rarely found in the USA [6]. Currently under discussion is whether the causative Borrelia subtype is exclusively Borrelia afzelii or possibly other species such as Borrelia burgdorferi sensu stricto or Borrelia garinii. Molecular...


Lyme Disease Borrelia Burgdorferi Lyme Borreliosis Venous Insufficiency Chronic Venous Insufficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the IZKF grant A2.


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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • T. G. Berger
    • 1
  • C. Schoerner
    • 2
  • H. Schell
    • 1
  • M. SimonJr
    • 1
  • G. Schuler
    • 1
  • M. Röllinghoff
    • 2
  • A. Gessner
    • 2
    Email author
  1. 1.Dermatologische Klinik der Universität Erlangen-NürnbergErlangenGermany
  2. 2.Institut für Klinische MikrobiologieImmunologie und Hygiene der Universität Erlangen-NürnbergErlangenGermany

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