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Fatal Acute Granulomatous Pulmonary Aspergillosis in a Healthy Subject After Inhalation of Vegetal Dust

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Abstract

A previously healthy 28-year-old man presented a few hours after inhalation of vegetal dust with acute bilateral community-acquired pneumonia, which caused death in 10 days despite treatment with broad-spectrum antibiotics, intravenous amphotericin B, inotropic support, and mechanical ventilation. A postmortem lung biopsy indicated miliary granulomatous pulmonary aspergillosis. Six similar previously published cases of acute granulomatous pulmonary aspergillosis are reviewed. This entity in adulthood may reveal a defect in neutrophil or macrophage function, such as late-onset chronic granulomatous disease.

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Correspondence to P. Germaud.

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Batard, E., Renaudin, K., Morin, O. et al. Fatal Acute Granulomatous Pulmonary Aspergillosis in a Healthy Subject After Inhalation of Vegetal Dust. Eur J Clin Microbiol Infect Dis 22, 357–359 (2003). https://doi.org/10.1007/s10096-003-0939-x

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  • DOI: https://doi.org/10.1007/s10096-003-0939-x

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