Abstract
A previously healthy 28-year-old man presented a few hours after inhalation of vegetal dust with acute bilateral community-acquired pneumonia, which caused death in 10 days despite treatment with broad-spectrum antibiotics, intravenous amphotericin B, inotropic support, and mechanical ventilation. A postmortem lung biopsy indicated miliary granulomatous pulmonary aspergillosis. Six similar previously published cases of acute granulomatous pulmonary aspergillosis are reviewed. This entity in adulthood may reveal a defect in neutrophil or macrophage function, such as late-onset chronic granulomatous disease.
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References
Soubani AO, Chandrasekar PH (2002) The clinical spectrum of pulmonary aspergillosis. Chest 121:1988–1999
Lecours R, Laviolette M, Cormier Y (1986) Bronchoalveolar lavage in pulmonary mycotoxicosis (organic dust toxic syndrome). Thorax 41:924–926
Meeker DP, Gephardt GN, Cordasco EM, Wiedemann HP (1991) Hypersensitivity pneumonitis versus invasive pulmonary aspergillosis: two cases with unusual pathologic findings and review of the literature. Am Rev Resp Dis 143:431–436
Kelly JK, Pinto AR, Whitelaw WA, Rorstad OP, Bowen TJ, Matheson DS (1986) Fatal aspergillus pneumonia in chronic granulomatous disease. Am J Clin Pathol 86:235–240
Trawick D, Kotch A, Matthay R, Homer RJ (1997) Eosinophilic pneumonia as a presentation of occult chronic granulomatous disease. Eur Resp J 10:2166–2170
Hillerdal G, Benson L, Lindgren A, Hjertquist SO (1984) Disseminated pulmonary aspergillosis in a previously healthy young woman. Scand J Infect Dis 16:217–222
Lavarde V, Belec L, Blanot S, Misset B, Carlet J (1992) Aspergillose pulmonaire invasive chez un patient non immunodéprimé. A propos d'un cas. J Mycol Med 2:95–98
Zuk JA, King D, Zakhour HD, Delaney JC (1989) Locally invasive pulmonary aspergillosis occurring in a gardener: an occupational hazard? Thorax 44:678–679
Chandler FW, Watts JC (1994) Fungal infections. In: Dail DH, Hammar SP (eds) Pulmonary pathology. Springer, New York, pp 351–427
Moskaluk C, Pogrebniak HW, Pass HI, Gallin JI, Travis WD (1994) Surgical pathology of the lung in chronic granulomatous disease. Am J Clin Pathol 102:684–691
Mouy R, Fischer A, Vilmer E, Seger R, Griscelli C (1989) Incidence, severity, and prevention of infections in chronic granulomatous disease. J Pediatr 114:555–560
Liese JG, Jendrossek V, Jansson A, Petropoulou T, Kloos S, Gahr M, Belohradsky BH (1996) Chronic granulomatous disease in adults. Lancet 347:220–223
Conrad DJ, Warnock M, Blanc P, Cowan M, Golden JA (1992) Microgranulomatous aspergillosis after shoveling wood chips: report of a fatal outcome in a patient with chronic granulomatous disease. Am J Ind Med 22:411–418
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Batard, E., Renaudin, K., Morin, O. et al. Fatal Acute Granulomatous Pulmonary Aspergillosis in a Healthy Subject After Inhalation of Vegetal Dust. Eur J Clin Microbiol Infect Dis 22, 357–359 (2003). https://doi.org/10.1007/s10096-003-0939-x
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DOI: https://doi.org/10.1007/s10096-003-0939-x