Abstract
Described here are two cases of cerebral aspergillosis successfully treated with voriconazole after the failure of first-line treatment with amphotericin B deoxycholate. In both cases, clinical and radiological cure was achieved within 6 weeks. Voriconazole should be considered as first-line therapy for cerebral aspergillosis.
This is a preview of subscription content, log in via an institution to check access.
References
Walsh TJ, Hier DB, Caplan LR (1985) Aspergillosis of the central nervous system: clinicopathological analysis of 17 patients. Ann Neurol 18:574–582
Torre-Cisneros J, Lopez OL, Kusne S, Martinez AJ, Starzl TE, Simmons RL, Martin M (1993) Aspergillosis in organ transplantation: a clinicopathological study. J Neurol Neurosurg Psychiatry 56:188–193
Boes B, Bashir R, Boes C, Hahn F, McConnell JR, McComb R (1994) Central nervous system aspergillosis. Analysis of 26 patients. J Neuroimaging 4:123–129
Stevens DA, Kan VL, Judson MA, Morrison VA, Dummer S, Denning DW, Bennett JE, Walsh TJ, Patterson TF, Pankey GA (2000) Practice guidelines for diseases caused by Aspergillus. Infectious Diseases Society of America. Clin Infect Dis 30:696–709
Denning DW (1998) Invasive aspergillosis. Clin Infect Dis 26:781–805
Denning DW, Lee JY, Hostetler JS, Pappas P, Kauffman CA, Dewsnup DH, Galgiani JN, Graybill JR, Sugar AM, Catanzaro A (1994) NIAID Mycoses Study Group Multicenter trial of oral itraconazole therapy for invasive aspergillosis. Am J Med 97:135–144
Karim M, Alam M, Shah AA, Ahmed R, Sheikh H (1997) Chronic invasive aspergillosis in apparently immunocompetent hosts. Clin Infect Dis 24:723–733
Coleman JM, Hogg GG, Rosenfeld JV, Waters KD (1995) Invasive central nervous system aspergillosis: cure with liposomal amphotericin B, itraconazole, and radical surgery: case report and review of the literature. Neurosurgery 36:858–863
Denning DW, Stevens DA (1990) Antifungal and surgical treatment of invasive aspergillosis: review of 2,121 published cases. Rev Infect Dis 12:1147–1201
Denning DW (1996) Therapeutic outcome of invasive aspergillosis. Clin Infect Dis 23:608–615
Hoffman HL, Rathbun RC (2002) Review of the safety and efficacy of voriconazole. Expert Opin Investig Drugs 11:409–429
Jezequel SG, Clark M, Evans K, Roffey S, Wastall P, Webster R (1995) UK-109,496, a novel, wide spectrum triazole derivative for the treatment of fungal infections: disposition on animals. In: Programs and Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. Abstract no. F-77
Denning DW (2002) Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis. Clin Infect Dis 34:573–571
Schwartz S, Milatovic D, Thiel E (1997) Successful treatment of cerebral aspergillosis with a novel triazole (voriconazole) in a patient with acute leukaemia. Br J Haematol 97:663–665
Herbrecht R, Denning DW, Patterson TF (2002) Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 347:408–415
Shellito JE, Quan Zheng M, Ye P, Ruan S, Shean MK, Kolls J (2001) Effect of alcohol consumption on host release of interleukin-17 during pulmonary infection with Klebsiella pneumoniae. Alcohol Clin Exp Res 25:872–881
Ascah KJ, Hyland RH, Hutcheon MA, Urbanski SJ, Pruzanski W, St Louis EL, Jones DP, Keystone EC (1984) Invasive aspergillosis in a "healthy" patient. Can Med Assoc J 131:332–335
Lortholary O, Meyohas MC, Dupont B, Cadranel J, Salmon-Ceron D, Peyramond D, Simonin D (1993) Invasive aspergillosis in patients with acquired immunodeficiency syndrome: report of 33 cases. French Cooperative Study Group on Aspergillosis in AIDS. Am J Med 95:177–187
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
de Lastours, V., Lefort, A., Zappa, M. et al. Two Cases of Cerebral Aspergillosis Successfully Treated with Voriconazole. Eur J Clin Microbiol Infect Dis 22, 297–299 (2003). https://doi.org/10.1007/s10096-003-0934-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-003-0934-2