Abstract
Described here is an unusual case of disseminated Cylindrocarpon lichenicola (Fusarium lichenicola) infection originating from a toenail lesion of a neutropenic woman with cellulitis of the foot and underlying acute leukaemia. A computed tomography scan of the chest showed multiple, ill-defined, nodular infiltrates with alveolar consolidation. The fungus was isolated from both the nail and the skin of the infected toe. Susceptibility testing revealed low minimum inhibitory concentrations for amphotericin B (0.78 µg/ml) and voriconazole (1.56 µg/ml) and high minimum inhibitory concentrations (>100 µg/ml) for fluconazole, ketoconazole and itraconazole. The infection resolved after treatment with a total dose of 1 g of amphotericin B followed by oral itraconazole and bone marrow regeneration.
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References
Brayford D (1987) Cylindrocarpon vaginae. CMI description of pathogenic fungi and bacteria. No. 930. Mycopathologia 100:133–134
Mangiaterra M, Giusiano G, Smilasky G, Zamar L, Amado G, Vicentin C (2001) Keratomycosis caused by Cylindrocarpon lichenicola. Med Mycol 39:143–145
De Hoog GS, Guarro J, Gené J, Figueras MJ (2000) Atlas of clinical fungi, 2nd edn. Centraalbureau voor Schimmelcultures, Utrech, The Netherlands, pp 613–619
Zoutman DE, Sigler L (1991) Mycetoma of the foot caused by Cylindrocarpon destructans. J Clin Microbiol 29:1855–1859
Hemashettar BM, Siddaramappa B, Padhye AA, Sigler L, Chandler FW (2000) White grain mycetoma caused by a Cylindrocarpon sp. in India. J Clin Microbiol 38:4288–4291
Sharma R, Farmer CK, Gransden WR, Ogg CS (1998) Peritonitis in continuous ambulatory peritoneal dialysis due to Cylindrocarpon lichenicola infection. Nephrol Dial Transplant 13:2662–2664
Iwen PC, Tarantolo SR, Sutton DA, Rinaldi MG, Hinrichs SH (2000) Cutaneous infection caused by Cylindrocarpon lichenicola in a patient with acute myelogenous leukemia. J Clin Microbiol 38:3375–3378
James EA, Orchard K, McWhinney PHW, Warnock DW, Johnson EM, Mehta AB, Kibbler CC (1997) Disseminated infection due to Cylindrocarpon lichenicola in a patient with acute myeloid leukaemia. J Infect 34:65–67
Guarro J, Gené J (1992) Fusarium infections. Criteria for the identification of the responsible species. Mycoses 35:109–114
Summerbell RC, Schroers HJ (2002) Analysis of phylogenetic relationship of Cylindrocarpon lichenicola and Acremonium falciforme to the Fusarium solani species complex and a review of similarities in the spectrum of opportunistic infections caused by these fungi. J Clin Microbiol 40:2866–2875
Gupta AK, Baran R, Summerbell RC (2000) Fusarium infections of the skin. Curr Opinion Infect Dis 13:121–128
Guarro J, Gene J (1995) Opportunistic fusarial infections in humans. Eur J Clin Microbiol Infect Dis 14:741–754
Nelson PJ, Dignani MC, Anaissie EJ (1994) Taxonomy, biology and clinical aspects of Fusarium species. Clin Microbiol Rev 7:479–504
Lamey B, Blanc C, Lapalu J (1985) Le Cylindrocarpon: nouvel agent d'intertrigo. Bull Soc Fr Mycol Med 14:73–76
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Rodríguez-Villalobos, H., Georgala, A., Beguin, H. et al. Disseminated Infection due to Cylindrocarpon (Fusarium) lichenicola in a Neutropenic Patient with Acute Leukaemia: Report of a Case and Review of the Literature. Eur J Clin Microbiol Infect Dis 22, 62–65 (2003). https://doi.org/10.1007/s10096-002-0851-9
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DOI: https://doi.org/10.1007/s10096-002-0851-9