Skip to main content

Advertisement

SpringerLink
Log in

Use of Voriconazole to Successfully Treat Disseminated Trichosporon asahii Infection in a Patient with Acute Myeloid Leukaemia

  • Consice Article
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract.

Trichosporon spp. is an emerging fungal pathogen in immunocompromised hosts, and disseminated infection is often fatal in neutropenic patients. Reported here is a case of disseminated infection in a neutropenic patient with acute leukaemia. After failure of amphotericin B and fluconazole therapy, the course of infection dramatically improved with voriconazole treatment. A literature search revealed 69 additional cases of disseminated Trichosporon spp. infections in neutropenic patients, and these are also reviewed. Clinical symptoms that suggest infection include fever, disseminated papulopustular cutaneous lesions and pulmonary involvement. Despite treatment with antifungal agents (amphotericin B, fluconazole), 78% of patients died. Voriconazole may represent a promising therapy for this life-threatening infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Author information

Authors and Affiliations

  1. Department of Infectious Diseases, Saint Louis Hospital, 1 Avenue Claude Vellefaux, 75010 Paris, France, , , , ,

    S. Fournier,  W. Pavageau &  J. Molina

  2. Laboratory of Parasitology, Saint Louis Hospital, Paris, France, , , , ,

    M. Feuillhade

  3. Division of Ophthalmology, Saint Louis Hospital, Paris, France, , , , ,

    S. Deplus

  4. Division of Radiology, Saint Louis Hospital, Paris, France, , , , ,

    A.-M. Zagdanski

  5. Division of Anatomopathology, Saint Louis Hospital, Paris, France, , , , ,

    O. Verola

  6. Division of Hematology, Saint Louis Hospital, Paris, France, , , , ,

    H. Dombret

Authors
  1. S. Fournier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Pavageau
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Feuillhade
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Deplus
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A.-M. Zagdanski
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. O. Verola
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H. Dombret
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. Molina
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Electronic Publication

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fournier, .S., Pavageau, .W., Feuillhade, .M. et al. Use of Voriconazole to Successfully Treat Disseminated Trichosporon asahii Infection in a Patient with Acute Myeloid Leukaemia. Eur J Clin Microbiol Infect Dis 21, 892–896 (2002). https://doi.org/10.1007/s10096-002-0841-y

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-002-0841-y

Keywords

Search

Navigation