Abstract.
In the study presented here immunologic markers and HIV RNA were related to specific antibody responses in 50 HIV-infected patients who had moderate immunodeficiency (median CD4+, 295) and were vaccinated with a pneumococcal polysaccharide vaccine. Low responses were associated with low IgG2 or high IgM levels (P=0.01) and good responses with high IgG4 (P=0.05) or IgG2 (P=0.07) or low β2 microglobulin (P=0.04) levels. A combination of IgG2 levels >1.0 g/l and IgM <1.6 g/l at baseline significantly predicted a twofold or better response in logistic regression analysis (P=0.025). Neither CD4+ lymphocyte counts nor HIV RNA levels were predictive, but it should be noted that good antibody responses were not restricted to patients with high CD4+ cell counts or low HIV RNA levels.
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Kvale, .D., Aaberge, .I. & Frøland, .S. Predictive Value of Immunologic Parameters and HIV RNA in Relation to Humoral Pneumococcal Polysaccharide Vaccine Responses in Patients with HIV Infection. Eur J Clin Microbiol Infect Dis 21, 688–690 (2002). https://doi.org/10.1007/s10096-002-0803-4
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DOI: https://doi.org/10.1007/s10096-002-0803-4