Journal of Wood Science

, Volume 56, Issue 6, pp 507–512 | Cite as

Antihyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin

  • Atsushi Honma
  • Tomoyuki KoyamaEmail author
  • Kazunaga Yazawa


The antihyperglycemic effects of the leaves of Acer amoenum and purification and identification of an active compound were investigated. In screening experiments for α-glucosidase inhibitory activity, methanolic extracts of A. amoenum leaves showed potent inhibitory action. This extract showed antihyperglycemic effects in sucrose-loaded mice. Fractionation of the crude extract gave the active compound corilagin [β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose] by spectroscopic analysis. This is the first report about the possibility of novel utilization of the Japanese maple tree as a source of compounds for prevention or treatment of diabetes mellitus.

Key words

Acer amoenum Diabetes mellitus α-Glucosidase inhibitory effect Japanese maple Corilagin 


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Copyright information

© The Japan Wood Research Society 2010

Authors and Affiliations

  • Atsushi Honma
    • 1
  • Tomoyuki Koyama
    • 1
    Email author
  • Kazunaga Yazawa
    • 1
  1. 1.Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and TechnologyTokyo University of Marine Science and TechnologyTokyoJapan

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