Antihyperglycemic effects of Japanese maple Acer amoenum leaf extract and its constituent corilagin
The antihyperglycemic effects of the leaves of Acer amoenum and purification and identification of an active compound were investigated. In screening experiments for α-glucosidase inhibitory activity, methanolic extracts of A. amoenum leaves showed potent inhibitory action. This extract showed antihyperglycemic effects in sucrose-loaded mice. Fractionation of the crude extract gave the active compound corilagin [β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose] by spectroscopic analysis. This is the first report about the possibility of novel utilization of the Japanese maple tree as a source of compounds for prevention or treatment of diabetes mellitus.
Key wordsAcer amoenum Diabetes mellitus α-Glucosidase inhibitory effect Japanese maple Corilagin
- 7.Aritomi M (1963) Chemical constituents in Aceraceous plants I. Flavonoid constituents in the leaves of Acer palmatum Thumberg (in Japanese). J Pharm Soc Jpn 83:737–740Google Scholar
- 15.Aritomi M (1964) Chemical constituents in Aceraceous plants. II. Flavonoid constituents in leaves of Acer carpinifolium Siebold et Zuccarini, A. diabolicum Blume, and A. negundo. J Pharm Soc Jpn 84:360–362Google Scholar