Abstract
The aqueous extract of the edible mushroom Sarcodon aspratus showed inhibitory effects against angiotensin I-converting enzyme (ACE). l-Pipecolic acid (l-piperidine-2-carboxylic acid) was isolated from a hot-water extract in a 0.02% yield as an active principle. The mode of inhibition of l-pipecolic acid was found to be competitive, whereas its d-isomer showed no significant inhibitory effects against ACE, suggesting that the configuration of the carboxyl group in the molecule plays an important role in the enzyme inhibition.
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Kiyoto, M., Saito, S., Hattori, K. et al. Inhibitory effects of l-pipecolic acid from the edible mushroom, Sarcodon aspratus, on angiotensin I-converting enzyme. J Wood Sci 54, 179–181 (2008). https://doi.org/10.1007/s10086-007-0923-7
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DOI: https://doi.org/10.1007/s10086-007-0923-7
Key words
- Angiotensin I-converting enzyme (ACE)
- Antihypertensive agent
- l-Pipecolic acid
- Sarcodon aspratus