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Managing tremor in fragile X-associated tremor/ataxia syndrome with botulinum neurotoxin: report of a success

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Fig. 1

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All data underlying the results are available as part of the article and no additional source data are required.

References

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Funding

No specific funding was received for this work.

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Authors and Affiliations

  1. Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy

    Angelo Tiziano Cimmino, Pasquale Sanginario, Anna Rita Bentivoglio, Martina Petracca & Giulia Di Lazzaro

  2. Fondazione Policlinico Universitario Agostino Gemelli IRCCS, UOC Neurologia, Rome, Italy

    Anna Rita Bentivoglio, Martina Petracca & Giulia Di Lazzaro

Authors
  1. Angelo Tiziano Cimmino
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  2. Pasquale Sanginario
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  3. Anna Rita Bentivoglio
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  4. Martina Petracca
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  5. Giulia Di Lazzaro
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Contributions

ATC: 1A, 1B, 1C, 2B, 2C 3A; PS: 1C, 3B; ARB: 3B; MP: 1C, 3B; GDL: 1A, 1B, 1C, 2A, 2B, 2C, 3B.

1 Research project: A. Conception, B. Organization, C. Execution;

2. Data Analysis: A. Design, B. Execution, C. Review and Critique;

3. Manuscript Preparation: A. Writing of the first draft, B. Review and Critique.

Corresponding author

Correspondence to Angelo Tiziano Cimmino.

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Patient’s written informed consent was obtained.

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The authors declare that there are no conflicts of interest relevant to this work.

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Highlights

• In FXTAS, tremor typically is the most disabling symptom in daily living activities.

• Tremor frequently lacks effective treatments, due to poor efficacy and side effects.

• We report an FXTAS man with disabling hand tremor, treated with BoNT injection.

• To evaluate the clinical response, an accelerometric assessment was performed.

• BoNT injections could be a valid approach for the treatment of tremor in FXTAS.

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Cimmino, A.T., Sanginario, P., Bentivoglio, A.R. et al. Managing tremor in fragile X-associated tremor/ataxia syndrome with botulinum neurotoxin: report of a success. Neurol Sci (2024). https://doi.org/10.1007/s10072-024-07594-6

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  • DOI: https://doi.org/10.1007/s10072-024-07594-6

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