Skip to main content

Advertisement

SpringerLink
Log in

Amyotrophic lateral sclerosis and myasthenia gravis overlaps syndrome: a series of case report

  • Letter to the Editor
  • Published:
Neurological Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Tai H et al (2017) Amyotrophic lateral sclerosis and myasthenia gravis overlap syndrome: a review of two cases and the associated literature. Front Neurol 8:218

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kvirkvelia N, Shakarishvili R, Kanashvili T (2018) Transformation of myasthenia gravis into amyotrophic lateral sclerosis, or their concomitance? (Case review). Georgian Med News 276:86–92

    Google Scholar 

  3. Ohnari K et al (2018) Late-onset myasthenia gravis accompanied by amyotrophic lateral sclerosis with antibodies against the acetylcholine receptor and low-density lipoprotein receptor-related protein 4. Intern Med 57(20):3021–3024

    Article  PubMed  PubMed Central  Google Scholar 

  4. Santos-Lasaosa S et al (2020) Amyotrophic lateral sclerosis and myasthenia gravis overlap syndrome: 3 new cases. Neurologia (Engl Ed) 35(8):595–597

    Article  CAS  PubMed  Google Scholar 

  5. Hodzic R et al (2021) Coexistence of myasthenia gravis and amyotrophic lateral sclerosis in a Bosnian male: an unusual clinical presentation. Acta Myol 40(1):66–68

    PubMed  PubMed Central  Google Scholar 

  6. Sun B et al (2022) Myasthenia gravis with amyotrophic lateral sclerosis with positive anti-Hu antibody: a rare co-existence. Acta Neurol Belg 123(1):315–317

    Article  PubMed  Google Scholar 

  7. Johnson IP, Longone P (2017) Commentary: Amyotrophic lateral sclerosis and myasthenia gravis overlap syndrome: a review of two cases and the associated literature. Front Neurol 8:356

    Article  PubMed  PubMed Central  Google Scholar 

  8. Jaretzki A 3rd et al (2000) Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Ann Thorac Surg 70(1): 327–34

  9. Brooks BR et al (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1(5):293–299

    Article  CAS  PubMed  Google Scholar 

  10. Turner MR et al (2013) Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study. Neurology 81(14):1222–1225

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Appel SH et al (1991) Immunoglobulins from animal models of motor neuron disease and from human amyotrophic lateral sclerosis patients passively transfer physiological abnormalities to the neuromuscular junction. Proc Natl Acad Sci U S A 88(2):647–651

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Malaspina A, Puentes F, Amor S (2015) Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective. Int Immunol 27(3):117–129

    Article  CAS  PubMed  Google Scholar 

  13. Verma S et al (2022) Neuromuscular junction dysfunction in amyotrophic lateral sclerosis. Mol Neurobiol 59(3):1502–1527

    Article  CAS  PubMed  Google Scholar 

  14. Fischer LR et al (2004) Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp Neurol 185(2):232–240

    Article  PubMed  Google Scholar 

  15. Olesen MN et al (2020) Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis. Neurol Neuroimmunol Neuroinflamm 7(3):e697

  16. Iwanami T et al (2011) Decremental responses to repetitive nerve stimulation (RNS) in motor neuron disease. Clin Neurophysiol 122(12):2530–2536

    Article  PubMed  Google Scholar 

  17. Okuyama Y et al (1997) Amyotrophic lateral sclerosis with anti-acetylcholine receptor antibody. Intern Med 36(4):312–315

    Article  CAS  PubMed  Google Scholar 

  18. Bruneteau G et al (2015) Endplate denervation correlates with Nogo-A muscle expression in amyotrophic lateral sclerosis patients. Ann Clin Transl Neurol 2(4):362–372

    Article  PubMed  PubMed Central  Google Scholar 

  19. Kiernan MC et al (2011) Amyotrophic lateral sclerosis. Lancet 377(9769):942–955

    Article  CAS  PubMed  Google Scholar 

  20. Zhang JH et al (2022) Analysis of disease progression rate and related factors in amyotrophic lateral sclerosis patients at initial visit. Zhonghua Yi Xue Za Zhi 102(3):222–227

    CAS  PubMed  Google Scholar 

  21. Keller AF, Gravel M, Kriz J (2011) Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice. Exp Neurol 228(1):69–79

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

  1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China

    Hengheng Wang, Na Chen, Fan Jian, Zaiqiang Zhang, Hongfei Tai & Hua Pan

  2. China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China

    Hengheng Wang, Na Chen, Fan Jian, Zaiqiang Zhang, Hongfei Tai & Hua Pan

  3. Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China

    Hongfei Tai

Authors
  1. Hengheng Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Na Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fan Jian
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zaiqiang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hongfei Tai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hua Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hua Pan.

Ethics declarations

Ethical approval

This study was approved by the Ethics Committee of Beijing Tiantan Hospital and was conducted in accordance with the Declaration of Helsinki.

Informed consent

The authors certify that they have obtained all appropriate participant consent forms. In the form, the patients have given their consent for their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity. Informed consent was obtained from patients enrolled in this study.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, H., Chen, N., Jian, F. et al. Amyotrophic lateral sclerosis and myasthenia gravis overlaps syndrome: a series of case report. Neurol Sci 45, 3549–3553 (2024). https://doi.org/10.1007/s10072-024-07369-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-024-07369-z

Search

Navigation