Skip to main content
SpringerLink
Log in

Prevalence, characteristics, and risk factors of venous thromboembolism in patients with brain tumor undergoing craniotomy: a meta-analysis

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Background

Brain tumor patients undergoing craniotomy are significantly associated with the development of venous thromboembolism (VTE), while the contributing factors remains controversial. Our study aimed to investigate the prevalence and risk factors for VTE in postoperational brain tumor patients.

Methods

We searched the PubMed, Embase, Web of Science, Medline, and Cochrane Library databases from their inception to July 2023. Article selection, data extraction, and study quality assessment were performed independently by two reviewers. Publication bias was assessed using Egger’s and Begg’s tests. Stata 15.0 software was used for data analysis.

Results

A total of 25 studies were considered, with a total of 49,620 brain tumor individuals. The pooled prevalence of VTE during hospitalization in postoperational brain tumor patients was 9% [95% CI: (0.08, 0.10)]. Moreover, our results demonstrated that patients with VTE were older than those without VTE [mean difference [MD] = 8.14, 95% CI: (4.97, 11.30)]. The following variables were significantly associated with VTE: prior history of VTE [OR = 7.81, 95% CI: (3.62, 16.88)], congestive heart failure [OR = 2.33, 95% CI: (1.08–5.05)], diabetes [OR = 1.87, 95% CI: (1.12–3.10)], hypertension [OR = 1.27, 95% CI: (1.07–1.50)], steroid use [OR = 1.63, 95% CI: (1.41, 1.88)], high white blood cells counts [MD = 0.32, 95% CI: (0.01, 0.63)], and high fibrinogen levels [MD = 0.19, 95% CI: (0.08, 0.30)].

Conclusion

This meta-analysis identified risk factors for postoperational VTE in patients with brain tumor, which can serve as a theoretical foundation for medical staff to manage and treat VTE.

Trial registration

CRD42023357459

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Sauro KM, Soo A, Kramer A, Couillard P, Kromm J, Zygun D, Niven DJ, Bagshaw SM, Stelfox HT (2019) Venous Thromboembolism prophylaxis in neurocritical care patients: are current practices, best practices? Neurocrit Care 30:355–363. https://doi.org/10.1007/s12028-018-0614-9

    Article  CAS  PubMed  Google Scholar 

  2. Semrad TJ, O'Donnell R, Wun T, Chew H, Harvey D, Zhou H, White RH (2007) Epidemiology of venous thromboembolism in 9489 patients with malignant glioma. J Neurosurg 106:601–608. https://doi.org/10.3171/jns.2007.106.4.601

    Article  PubMed  Google Scholar 

  3. Silvani A, Gaviani P, Lamperti E, Botturi A, Ferrari D, Simonetti G, Fariselli L, Salmaggi A (2011) Metabolic, electrolytes disorders and tromboembolic risk in malignant glioma patients. Neurol Sci Official J Italian Neurol Soc Italian Society Clin Neurophysiol 32(Suppl 2):S229–S231. https://doi.org/10.1007/s10072-011-0793-z

    Article  Google Scholar 

  4. Beckman MG, Hooper WC, Critchley SE, Ortel TL (2010) Venous thromboembolism: a public health concern. Am J Prev Med 38:S495–S501. https://doi.org/10.1016/j.amepre.2009.12.017

    Article  PubMed  Google Scholar 

  5. Raskob GE, Silverstein R, Bratzler DW, Heit JA, White RH (2010) Surveillance for deep vein thrombosis and pulmonary embolism: recommendations from a national workshop. Am J Prev Med 38:S502–S509. https://doi.org/10.1016/j.amepre.2010.01.010

    Article  PubMed  Google Scholar 

  6. Rinaldo L, Brown DA, Bhargav AG, Rusheen AE, Naylor RM, Gilder HE, Monie DD, Youssef SJ, Parney IF (2019) Venous thromboembolic events in patients undergoing craniotomy for tumor resection: incidence, predictors, and review of literature. J Neurosurg 132:10–21. https://doi.org/10.3171/2018.7.Jns181175

    Article  PubMed  Google Scholar 

  7. Turpie AGG, Farjat AE, Haas S, Ageno W, Weitz JI, Goldhaber SZ, Goto S, Angchaisuksiri P, Kayani G, Lopes RD et al (2023) 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE. Thromb Res 222:31–39. https://doi.org/10.1016/j.thromres.2022.11.016

    Article  CAS  PubMed  Google Scholar 

  8. Sørensen HT, Mellemkjaer L, Olsen JH, Baron JA (2000) Prognosis of cancers associated with venous thromboembolism. N Engl J Med 343:1846–1850. https://doi.org/10.1056/nejm200012213432504

    Article  PubMed  Google Scholar 

  9. Hoefnagel D, Kwee LE, van Putten EH, Kros JM, Dirven CM, Dammers R (2014) The incidence of postoperative thromboembolic complications following surgical resection of intracranial meningioma. A retrospective study of a large single center patient cohort. Clin Neurol Neurosurg 123:150–154. https://doi.org/10.1016/j.clineuro.2014.06.001

    Article  PubMed  Google Scholar 

  10. Kim AS, Khorana AA, McCrae KR (2020) Mechanisms and biomarkers of cancer-associated thrombosis. Trans Res J Lab Clin Med 225:33–53. https://doi.org/10.1016/j.trsl.2020.06.012

    Article  CAS  Google Scholar 

  11. Smith TR, Nanney AD 3rd, Lall RR, Graham RB, McClendon J Jr, Lall RR, Adel JG, Zakarija A, Cote DJ, Chandler JP (2015) Development of venous thromboembolism (VTE) in patients undergoing surgery for brain tumors: results from a single center over a 10 year period. J Clin Neurosci 22:519–525. https://doi.org/10.1016/j.jocn.2014.10.003

    Article  PubMed  Google Scholar 

  12. Senders JT, Goldhaber NH, Cote DJ, Muskens IS, Dawood HY, De Vos F, Gormley WB, Smith TR, Broekman MLD (2018) Venous thromboembolism and intracranial hemorrhage after craniotomy for primary malignant brain tumors: a National Surgical Quality Improvement Program analysis. J Neuro-Oncol 136:135–145. https://doi.org/10.1007/s11060-017-2631-5

    Article  Google Scholar 

  13. Cote DJ, Dubois HM, Karhade AV, Smith TR (2016) Venous thromboembolism in patients undergoing craniotomy for brain tumors: a U.S. nationwide analysis. Semin Thromb Hemost 42:870–876. https://doi.org/10.1055/s-0036-1592306

    Article  PubMed  Google Scholar 

  14. Chaichana KL, Pendleton C, Jackson C, Martinez-Gutierrez JC, Diaz-Stransky A, Aguayo J, Olivi A, Weingart J, Gallia G, Lim M et al (2013) Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors. Neurol Res 35:206–211. https://doi.org/10.1179/1743132812y.0000000126

    Article  CAS  PubMed  Google Scholar 

  15. Moher D, Liberati A, Tetzlaff J, Altman DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Intl J Surg (London, England) 8:336–341. https://doi.org/10.1016/j.ijsu.2010.02.007

    Article  Google Scholar 

  16. Wells GA, Wells G, Shea B, Shea B, O'Connell D, Peterson J, Welch, Losos M, Tugwell P, Ga SW et al (2014) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses

  17. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ (Clinical research ed) 327:557–560. https://doi.org/10.1136/bmj.327.7414.557

    Article  PubMed  Google Scholar 

  18. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558. https://doi.org/10.1002/sim.1186

    Article  PubMed  Google Scholar 

  19. Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101

    Article  CAS  PubMed  Google Scholar 

  20. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ (Clinical research ed) 315:629–634. https://doi.org/10.1136/bmj.315.7109.629

    Article  CAS  PubMed  Google Scholar 

  21. Algattas H, Talentino SE, Eichar B, Williams AA, Murphy JM, Zhang X, Garcia RM, Newhouse D, Jaman E, Safonova A et al (2021) Venous thromboembolism anticoagulation prophylaxis timing in patients undergoing craniotomy for tumor. Neurosurgery Open 2. https://doi.org/10.1093/neuopn/okaa018

  22. Ambulkar R, Parab SY, Vignesh B, Nagargoje V, Janu A, Parikh P, Moiyadi A (2023) A prospective study to evaluate the use of surveillance venous ultrasonography to detect incidence of deep venous thrombosis following neurosurgical excision of brain tumors. J Neurosci Rural Pract 14:252-257. 10.25259/JNRP_26_2022

  23. Bervitskiy AV, Moisak GI, Guzhin VE, Amelina EV, Kalinovskiy AV, Rzaev DA (2021) [Incidence and risk factors of venous thromboembolic events after resection of various brain tumors]. Zh Vopr Neirokhir Im N N Burdenko 85:63-75. 10.17116/neiro20218503163

  24. Brandes AA, Scelzi E, Salmistraro G, Ermani M, Carollo C, Berti F, Zampieri P, Baiocchi C, Fiorentino MV (1997) Incidence of risk of thromboembolism during treatment high-grade gliomas: a prospective study. Eur J Cancer 33:1592–1596. https://doi.org/10.1016/s0959-8049(97)00167-6

    Article  CAS  PubMed  Google Scholar 

  25. Carrabba G, Riva M, Conte V, Di Cristofori A, Caroli M, Locatelli M, Castellani M, Bucciarelli P, Artoni A, Stocchetti N et al (2018) Risk of post-operative venous thromboembolism in patients with meningioma. J Neuro-Oncol 138:401–406. https://doi.org/10.1007/s11060-018-2810-z

    Article  Google Scholar 

  26. Gerber DE, Segal JB, Salhotra A, Olivi A, Grossman SA, Streiff MB (2007) Venous thromboembolism occurs infrequently in meningioma patients receiving combined modality prophylaxis. Cancer 109:300–305. https://doi.org/10.1002/cncr.22405

    Article  PubMed  Google Scholar 

  27. Gok H, Baskurt O, Sarigul B, Gurbuz D, Celik SE (2023) Silent pulmonary thromboembolism in patients undergoing craniotomy for brain tumor. Turk Neurosurg 33:87–93. https://doi.org/10.5137/1019-5149.JTN.36806-21.2

    Article  PubMed  Google Scholar 

  28. Kaewborisutsakul A, Tunthanathip T, Yuwakosol P, Inkate S, Pattharachayakul S (2020) Incidence and risk factors for venous thromboembolism following craniotomy for intracranial tumors: a cohort study. Asian J Neurosurg 15:31–38. https://doi.org/10.4103/ajns.AJNS_351_19

    Article  PubMed  PubMed Central  Google Scholar 

  29. Lasica N, Djilvesi D, Papic V, Karan M, Jelaca B, Golubovic J, Pajicic F, Medic-Stojanoska M, Vulekovic P, Rasulic L (2022) Venous thromboembolic and hemorrhagic events after meningioma surgery: a single-center retrospective cohort study of risk factors. PLoS One 17:e0273189. https://doi.org/10.1371/journal.pone.0273189

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Liu X, Zhang X, Ma T, Li M, Zhang L, Li S, Zeng M, Kass IS, Peng Y (2023) Risk factors for postoperative thrombosis-related complications in patients undergoing malignant brain tumor resection: a retrospective cohort study. Front Neurol 14:1108596. https://doi.org/10.3389/fneur.2023.1108596

    Article  PubMed  PubMed Central  Google Scholar 

  31. Nakano F, Matsubara T, Ishigaki T, Hatazaki S, Mouri G, Nakatsuka Y, Suzuki H (2018) Incidence and risk factor of deep venous thrombosis in patients undergoing craniotomy for brain tumors: a Japanese single-center, retrospective study. Thromb Res 165:95–100. https://doi.org/10.1016/j.thromres.2018.03.016

    Article  CAS  PubMed  Google Scholar 

  32. Nunno A, Li Y, Pieters TA, Towner JE, Schmidt T, Shi M, Walter K, Li YM (2019) Risk factors and associated complications of symptomatic venous thromboembolism in patients with craniotomy for meningioma. World Neurosurg 122:e1505–e1510. https://doi.org/10.1016/j.wneu.2018.11.091

    Article  PubMed  Google Scholar 

  33. Okamoto E, Ishikawa E, Kino H, Kohzuki H, Sugii N, Naito H, Hara T, Homma S, Matsuda M, Tsurubuchi T et al (2022) Perioperative deep vein thrombosis and d-dimer measurement in patients with brain tumor. Neurol Med Chir (Tokyo) 62:186-194. 10.2176/jns-nmc.2021-0339

  34. Qiao N, Zhang Q, Chen L, He W, Ma Z, Ye Z, He M, Zhang Z, Zhou X, Shen M et al (2023) Machine learning prediction of venous thromboembolism after surgeries of major sellar region tumors. Thromb Res 226:1–8. https://doi.org/10.1016/j.thromres.2023.04.007

    Article  CAS  PubMed  Google Scholar 

  35. Safaee M, Sun MZ, Oh T, Aghi MK, Berger MS, McDermott MW, Parsa AT, Bloch O (2014) Use of thrombin-based hemostatic matrix during meningioma resection: a potential risk factor for perioperative thromboembolic events. Clin Neurol Neurosurg 119:116–120. https://doi.org/10.1016/j.clineuro.2014.01.021

    Article  PubMed  Google Scholar 

  36. Shi S, Cheng J, Chen H, Zhang Y, Zhao Y, Wang B (2020) Preoperative and intraoperative predictors of deep venous thrombosis in adult patients undergoing craniotomy for brain tumors: a Chinese single-center, retrospective study. Thromb Res 196:245–250. https://doi.org/10.1016/j.thromres.2020.09.005

    Article  CAS  PubMed  Google Scholar 

  37. Shi S, Cheng J, Zhao Y, Chen W (2021) Incidence, and preoperative and intraoperative prognostic factors of deep venous thrombosis in patients with glioma following craniotomy. Clin Neurol Neurosurg 210:106998. https://doi.org/10.1016/j.clineuro.2021.106998

    Article  PubMed  Google Scholar 

  38. Smith TR, Lall RR, Graham RB, McClendon J Jr, Lall RR, Nanney AD, Adel JG, Zakarija A, Chandler JP (2014) Venous thromboembolism in high grade glioma among surgical patients: results from a single center over a 10 year period. J Neuro-Oncol 120:347–352. https://doi.org/10.1007/s11060-014-1557-4

    Article  Google Scholar 

  39. Zhang C, Deng Z, Yang Z, Xie J, Hou Z (2023) A nomogram model to predict the acute venous thromboembolism risk after surgery in patients with glioma. Thromb Res 224:21–31. https://doi.org/10.1016/j.thromres.2023.02.002

    Article  CAS  PubMed  Google Scholar 

  40. Pandey A, Thakur B, Hogg F, Brogna C, Logan J, Arya R, Gullan R, Bhangoo R, Ashkan K (2018) The role of preoperative deep vein thrombosis screening in neurooncology. J Neurosurg 130:38–43. https://doi.org/10.3171/2017.9.Jns17176

    Article  PubMed  Google Scholar 

  41. Alshehri N, Cote DJ, Hulou MM, Alghamdi A, Alshahrani A, Mekary RA, Smith TR (2016) Venous thromboembolism prophylaxis in brain tumor patients undergoing craniotomy: a meta-analysis. J Neuro-Oncol 130:561–570. https://doi.org/10.1007/s11060-016-2259-x

    Article  CAS  Google Scholar 

  42. Qian C, Yan H, Hu X, Zhang W, Liu H (2016) Increased risk of venous thromboembolism in patients with brain tumors: a systematic review and meta-analysis. Thromb Res 137:58–63. https://doi.org/10.1016/j.thromres.2015.11.018

    Article  CAS  PubMed  Google Scholar 

  43. Anderson BP, Sioshansi PC, Conway RM, Minutello K, Bojrab DI, Hong RS, Sargent EW, Schutt CA, Bojrab DI 2nd, Zappia JJ et al (2022) Rate of development of venous thromboembolism in lateral skull base surgery. Laryngoscope 132:662–667. https://doi.org/10.1002/lary.29889

    Article  PubMed  Google Scholar 

  44. Hong KC, Kim H, Kim JY, Kwak KS, Cho OM, Cha HY, Lim SH, Song YJ (2012) Risk factors and incidence of deep vein thrombosis in lower extremities among critically ill patients. J Clin Nurs 21:1840–1846. https://doi.org/10.1111/j.1365-2702.2012.04112.x

    Article  PubMed  Google Scholar 

  45. Hill J, Treasure T (2007) Reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in inpatients having surgery: summary of NICE guidance. BMJ (Clinical research ed) 334:1053–1054. https://doi.org/10.1136/bmj.39174.678032.AD

    Article  PubMed  Google Scholar 

  46. Schrag D, Uno H, Rosovsky R, Rutherford C, Sanfilippo K, Villano JL, Drescher M, Jayaram N, Holmes C, Feldman L et al (2023) Direct oral anticoagulants vs low-molecular-weight heparin and recurrent VTE in patients with cancer: a randomized clinical trial. Jama 329:1924–1933. https://doi.org/10.1001/jama.2023.7843

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Kaptein FHJ, Stals MAM, Kapteijn MY, Cannegieter SC, Dirven L, van Duinen SG, van Eijk R, Huisman MV, Klaase EE, Taphoorn MJB et al (2022) Incidence and determinants of thrombotic and bleeding complications in patients with glioblastoma. J Thrombosis Haemostasis : JTH 20:1665–1673. https://doi.org/10.1111/jth.15739

    Article  CAS  Google Scholar 

  48. Jo J, Diaz M, Horbinski C, Mackman N, Bagley S, Broekman M, Rak J, Perry J, Pabinger I, Key NS et al (2023) Epidemiology, biology, and management of venous thromboembolism in gliomas: an interdisciplinary review. Neuro-Oncology 25:1381–1394. https://doi.org/10.1093/neuonc/noad059

    Article  CAS  PubMed  Google Scholar 

  49. Simanek R, Vormittag R, Hassler M, Roessler K, Schwarz M, Zielinski C, Pabinger I, Marosi C (2007) Venous thromboembolism and survival in patients with high-grade glioma. Neuro-Oncology 9:89–95. https://doi.org/10.1215/15228517-2006-035

    Article  PubMed  PubMed Central  Google Scholar 

  50. Riedl J, Ay C (2019) Venous thromboembolism in brain tumors: risk factors, molecular mechanisms, and clinical challenges. Semin Thromb Hemost 45:334–341. https://doi.org/10.1055/s-0039-1688493

    Article  PubMed  PubMed Central  Google Scholar 

  51. Khalil J, Bensaid B, Elkacemi H, Afif M, Bensaid Y, Kebdani T, Benjaafar N (2015) Venous thromboembolism in cancer patients: an underestimated major health problem. World J Surg Oncol 13:204. https://doi.org/10.1186/s12957-015-0592-8

    Article  PubMed  PubMed Central  Google Scholar 

  52. Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL (2020) Current approaches to the management of brain metastases. Nat Rev Clin Oncol 17:279–299. https://doi.org/10.1038/s41571-019-0320-3

    Article  PubMed  Google Scholar 

  53. Pinzi V, Orsi C, Marchetti M, Milanesi IM, Bianchi LC, DiMeco F, Cuccarini V, Farinotti M, Ferroli P, Finocchiaro G et al (2015) Radiosurgery reirradiation for high-grade glioma recurrence: a retrospective analysis. Neurol Sci Official J Italian Neurol Soc Italian Society Clin Neurophysiol 36:1431–1440. https://doi.org/10.1007/s10072-015-2172-7

    Article  Google Scholar 

  54. Lyman GH, Kuderer NM (2020) Clinical practice guidelines for the treatment and prevention of cancer-associated thrombosis. Thromb Res 191(Suppl 1):S79–s84. https://doi.org/10.1016/s0049-3848(20)30402-3

    Article  CAS  PubMed  Google Scholar 

  55. Practice American Diabetes Association Professional, C, (2022) 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022. Diabetes care 45:S17–S38. https://doi.org/10.2337/dc22-S002

    Article  Google Scholar 

  56. Bell EJ, Folsom AR, Lutsey PL, Selvin E, Zakai NA, Cushman M, Alonso A (2016) Diabetes mellitus and venous thromboembolism: a systematic review and meta-analysis. Diabetes Res Clin Pract 111:10–18. https://doi.org/10.1016/j.diabres.2015.10.019

    Article  PubMed  Google Scholar 

  57. Palermo NE, Gianchandani RY, McDonnell ME, Alexanian SM (2016) Stress hyperglycemia during surgery and anesthesia: pathogenesis and clinical implications. Current Diabetes Reports 16:33. https://doi.org/10.1007/s11892-016-0721-y

    Article  CAS  PubMed  Google Scholar 

  58. Clarke RS (1970) The hyperglycaemic response to different types of surgery and anaesthesia. Br J Anaesth 42:45–53. https://doi.org/10.1093/bja/42.1.45

    Article  CAS  PubMed  Google Scholar 

  59. Dąbrowska E, Narkiewicz K (2023) Hypertension and dyslipidemia: the two partners in endothelium-related crime. Curr Atheroscler Rep 25:605–612. https://doi.org/10.1007/s11883-023-01132-z

    Article  PubMed  PubMed Central  Google Scholar 

  60. Gonzalez Della Valle A, Shanaghan KA, Nguyen J, Liu J, Memtsoudis S, Sharrock NE, Salvati EA (2020) Multimodal prophylaxis in patients with a history of venous thromboembolism undergoing primary elective hip arthroplasty. The bone & joint journal 102-b:71-77. 10.1302/0301-620x.102b7.Bjj-2019-1559.R1

  61. Kakkar VV, Howe CT, Nicolaides AN, Renney JT, Clarke MB (1970) Deep vein thrombosis of the leg. Is there a “high risk” group? Am J Surg 120:527–530. https://doi.org/10.1016/s0002-9610(70)80023-x

    Article  CAS  PubMed  Google Scholar 

  62. White RH, Henderson MC (2002) Risk factors for venous thromboembolism after total hip and knee replacement surgery. Curr Opin Pulm Med 8:365–371. https://doi.org/10.1097/00063198-200209000-00004

    Article  PubMed  Google Scholar 

  63. White RH, Zhou H, Gage BF (2004) Effect of age on the incidence of venous thromboembolism after major surgery. J Thrombosis Haemostasis : JTH 2:1327–1333. https://doi.org/10.1046/j.1538-7836.2004.00848.x

    Article  CAS  Google Scholar 

  64. Lieber BA, Han J, Appelboom G, Taylor BE, Han B, Agarwal N, Connolly ES Jr (2016) Association of steroid use with deep venous thrombosis and pulmonary embolism in neurosurgical patients: a national database analysis. World Neurosurg 89:126–132. https://doi.org/10.1016/j.wneu.2016.01.033

    Article  PubMed  Google Scholar 

  65. Sarlos P, Szemes K, Hegyi P, Garami A, Szabo I, Illes A, Solymar M, Petervari E, Vincze A, Par G et al (2018) Steroid but not biological therapy elevates the risk of venous thromboembolic events in inflammatory bowel disease: a meta-analysis. J Crohn's & Colitis 12:489–498. https://doi.org/10.1093/ecco-jcc/jjx162

    Article  Google Scholar 

  66. Børvik T, Evensen LH, Morelli VM, Melbye H, Brækkan SK, Hansen JB (2020) Impact of respiratory symptoms and oxygen saturation on the risk of incident venous thromboembolism-the Tromsø study. Res Practice Thrombosis Haemostasis 4:255–262. https://doi.org/10.1002/rth2.12299

    Article  CAS  Google Scholar 

Download references

Funding

This study was funded by the Open Project Program of Key Laboratory of Big Data Analysis and Knowledge Services of Yangzhou University (YBK202202), the National Natural Science Foundation of China (No. 72374178, No. 71904165, No. 82172603), the Natural Science Foundation of Jiangsu Province (BK20221280), the Special Fund for Social Key Research and Development Plan of Yangzhou City (YZ2022097), the Chinese Postdoctoral Science Foundation (2022M711426), the Jiangsu Provincial Health Commission New Technology Introduction and Evaluation Project (M2022044).

Author information

Authors and Affiliations

  1. School of Nursing, Medical College of Yangzhou University, Yangzhou University, Yangzhou, China

    Qingping Zeng, Jiali Ding, Juan Chen & Xianru Gao

  2. Department of Neuro Intensive Care Unit, Clinical Medical College of Yangzhou University, Yangzhou, China

    Qingping Zeng, Jiali Ding, Juan Chen, Xianru Gao, Yujia Huang, Tian Shi, Hailong Yu & Yuping Li

  3. School of Public Health, Medical College of Yangzhou University, Yangzhou University, Yangzhou, China

    Guangyu Lu

  4. Department of Echocardiography, Northern Jiangsu People’s Hospital, Yangzhou, China

    Jing Yuan

  5. Neuro-Intensive Care Unit, Department of Neurosurgery, Clinical Medical College, Yangzhou University, Yangzhou, 225001, Jiangsu, China

    Yujia Huang, Tian Shi & Yuping Li

  6. Department of Neurology, Northern Jiangsu People’s Hospital, Yangzhou, China

    Hailong Yu

  7. Department of Neurosurgery, Nanjing Drum Tower Hospital, School of Medicine, Clinical College of Nanjing Medical University, Nanjing, 210008, Jiangsu, China

    Hongbin Ni

Authors
  1. Qingping Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Guangyu Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jing Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jiali Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Juan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xianru Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yujia Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Tian Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hailong Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hongbin Ni
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yuping Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors played a part in the planning of the meta-analysis. The first two authors (GYL and QPZ) undertook the literature search and obtained the data from published literature. The data were analyzed by QPZ, and the initial draft of the manuscript was undertaken by GYL, QPZ, and YPL. All authors reviewed the initial draft of the manuscript and helped prepare the final draft for submission. All authors have critically read and approved the final manuscript.

Corresponding authors

Correspondence to Hongbin Ni or Yuping Li.

Ethics declarations

Ethical approval

None.

Consent to participate

No informed consents were required for the purpose of the current study.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Qingping Zeng, Guangyu Lu, and Jing Yuan should be considered joint first author.

Supplementary Information

ESM 1

(DOCX 63 kb)

ESM 2

(DOCX 1418 kb)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zeng, Q., Lu, G., Yuan, J. et al. Prevalence, characteristics, and risk factors of venous thromboembolism in patients with brain tumor undergoing craniotomy: a meta-analysis. Neurol Sci 45, 1565–1580 (2024). https://doi.org/10.1007/s10072-023-07160-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-023-07160-6

Keywords

Search

Navigation