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Relationship between serum uric acid levels and the outcome of STN-DBS in Parkinson’s disease

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Abstract

Background

Uric acid is a natural antioxidant and it has been shown that low levels of uric acid may be a risk factor for the development of Parkinson’s disease. We aimed to investigate the relationship between uric acid and improvement of motor symptoms in patients with Parkinson’s disease after subthalamic nucleus deep brain stimulation.

Methods

We analyzed the correlation between serum uric acid levels in 64 patients with Parkinson’s disease and the rate of improvement of motor symptoms 2 years after subthalamic nucleus deep brain stimulation.

Results

A non-linear correlation was observed between uric acid levels and the rate of motor symptom improvement after subthalamic nucleus deep brain stimulation, during both the drug-off and drug-on periods.

Conclusions

Uric acid is positively associated with the rate of motor symptom improvement in subthalamic nucleus deep brain stimulation within a certain range.

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Acknowledgements

We would like to thank all authors for this study.

Funding

This paper is supported by the Special Fund Project for Guiding Local Science and Technology Development by the Central Government (No.: 2019b07030001) and Doctoral Research Fund of the First Affiliated Hospital of USTC (No.: RC2021121).

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, People’s Republic of China

    Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang & Chaoshi Niu

  2. Anhui Province Key Laboratory of Brain Function and Brain Disease, Hefei, 230001, People’s Republic of China

    Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang & Chaoshi Niu

Authors
  1. Bowen Chang
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  2. Chen Ni
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  3. Jiaming Mei
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  4. Chi Xiong
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  5. Peng Chen
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  6. Manli Jiang
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  7. Chaoshi Niu
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Contributions

BWC and CN jointly completed the experiment and the writing; CX, JMM, PC, and MLJ assisted in the writing and followed up patients. CSN took the overall control of the whole study. All authors contributed to the article and approved the submitted version.

Corresponding author

Correspondence to Chaoshi Niu.

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The authors declare no competing interests.

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Chang, B., Ni, C., Mei, J. et al. Relationship between serum uric acid levels and the outcome of STN-DBS in Parkinson’s disease. Neurol Sci 44, 3913–3917 (2023). https://doi.org/10.1007/s10072-023-06911-9

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  • DOI: https://doi.org/10.1007/s10072-023-06911-9

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