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Parkinson’s disease patients combined with constipation tend to have higher serum expression of microRNA 29c, prominent neuropsychiatric disorders, possible RBD conversion, and a substandard quality of life

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Abstract

Introduction

The symptom of constipation has been confirmed as an early diagnose criteria for Parkinson’s disease (PD). Furthermore, evidences suggest that pathogenesis of PD initiates in gut, rather than brain. If so, identifying biomarkers for constipation in PD might have potentials to assist early diagnosis and initial treatment.

Method

We first identified that microRNA 29c (miR-29c) was dysregulated both in PD and constipation patients through bioinformatics analysis. Then, serological analysis of the expression of miR-29c in 67 PD patients with constipation (PD–C), 51 PD patients without constipation (PD-NC), and 50 healthy controls (HC) was carried out by qPCR. Demographic and clinical features were also compared. Patients in PD–C group were further classified into two groups: those with prodromal stage constipation (PD–C-Pro) (n = 36) and those with clinical stage constipation (PD–C-Clinic) (n = 31), to explore their different characteristics.

Results

The levels of miR-29c in PD–C group were higher than that in PD-NC group, both higher than HC group. PD–C-Pro group’s miR-29c levels were statistically higher compared with PD–C-Clinic group’s. What is more, PD–C group had higher scores of MDS-UPDRS-I, NMSS, NMSS3, NMSS4, NMSS6, NMSS9, SCOPA-AUT, HAMD, HAMA, RBDSQ, CSS, and PACQOL compared with PD-NC party. Relative to the PD–C-Clinic, patients in PD–C-Pro group had higher MDS-UPDRS-I, NMSS, NMSS3, HAMD, and HAMA scores, and were more likely to have RBD.

Conclusion

Our results indicated that miR-29c seems to be an underlying cause for developing constipation in patients with PD and PD–C identifies a group of patients with more severe non-motor impairment, prominent neuropsychiatric disorders, and possible RBD conversion as well as a substandard quality of life. We further confirmed that there is a close relationship between symptoms representing the same pathological origin, especially constipation and RBD.

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Data availability

Datasets associated with the present study are available upon reasonable request of interested researchers.

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Acknowledgements

We thank all participants who contributed to this study. We express our sincere appreciation to the reviewers for their constructive comments.

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Authors and Affiliations

  1. Department of Neurology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China

    Hong Liu, Lei Shen, Haonan Zhao, Jie Yang & Dongya Huang

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  1. Hong Liu
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Correspondence to Hong Liu.

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The studies involving human participants were reviewed and approved by the ethics committee of the Shanghai East hospital affiliated with Tongji University. The patients/participants provided their written informed consent to participate in this study.

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Liu, H., Shen, L., Zhao, H. et al. Parkinson’s disease patients combined with constipation tend to have higher serum expression of microRNA 29c, prominent neuropsychiatric disorders, possible RBD conversion, and a substandard quality of life. Neurol Sci 44, 3141–3150 (2023). https://doi.org/10.1007/s10072-023-06793-x

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