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An S-like curve relationship between systemic inflammation response index (SIRI) and respiratory failure in GBS patients

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Abstract

Background

Our study examined the association between the initial systemic inflammation response index (SIRI) and respiratory failure in patients with Guillain-Barré syndrome (GBS).

Methods

The weighted linear regression model, weighted chi-square test, logistic regression models, smooth curve fittings, and the two-piece linear regression model were utilized for data analysis.

Results

Among the 443 GBS patients, 75 (6.9%) had experienced respiratory failure. According to logistic regression models, there existed no consistent linear relationship between respiratory failure and SIRI in model 1 (OR = 1.2, p < 0.001), model 2 (OR = 1.2, p < 0.001), and model 3 (OR = 1.3, p = 0.017). However, smooth curve fittings found an S-like curve relationship between SIRI and respiratory failure. Furthermore, when SIRI was < 6.4, there existed a positive correlation between SIRI and respiratory failure in model 1 (OR = 1.5, 95% CI = (1.3, 1.8), p < 0.0001), higher correlation in model 2 (OR = 1.6, 95% CI = (1.3, 1.8), p < 0.0001), and highest correlation in model 3 (OR = 1.6, 95% CI = (1.3, 2.5), p < 0.0001).

Conclusions

SIRI can be used as a predictor of respiratory failure in GBS, and an S-like relationship exists between SIRI and respiratory failure at an infliction point of 6.4. When the SIRI was less than 6.4 and increased, SIRI was associated with a higher occurrence of respiratory failure. The risk of respiratory failure was no longer increased when the SIRI was over 6.4.

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Data Availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

Appreciation is expressed to the Resource Collection and Standardized Diagnosis and Treatment Platform for Neurogenetic and Neurodegenerative Disease (19JDPT0015).

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Authors and Affiliations

  1. Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan, 610041, People’s Republic of China

    Qiuyan Shen, Yi Bao, Fang Xu, Dan Zhang, Anling Luo, Ling Liu, Hongyan Huang & Yanming Xu

  2. Department of Neurology, Chengdu First People’s Hospital, 18 Wanxiang North Road, Chengdu, Sichuan, 610041, People’s Republic of China

    Xin Mu

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  1. Qiuyan Shen
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Correspondence to Yanming Xu.

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Ethical approval and Informed consent statement

This study was approved by the Ethics Committee of West China Hospital, Sichuan University. Written informed consent was obtained from all patients for their anonymized clinical data to be published for research purposes.

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Qiuyan Shen and Xin Mu are co-first authors.

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Shen, Q., Mu, X., Bao, Y. et al. An S-like curve relationship between systemic inflammation response index (SIRI) and respiratory failure in GBS patients. Neurol Sci 44, 3279–3285 (2023). https://doi.org/10.1007/s10072-023-06784-y

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