Data availability
The data that support the findings of this case report are fully available from the corresponding author, [S.S.], upon reasonable request.
References
Gorman MP, Healy BC, Polgar-Turcsany M, Chitnis T (2009) Increased relapse rate in pediatric-onset compared with adult-onset multiple sclerosis. Arch Neurol 66:54–59
Baroncini D, Simone M, Iaffaldano P, Italian MS, registry, et al (2021) Risk of persistent disability in patients with pediatric-onset multiple sclerosis. JAMA Neurol 78:726–735
Ghezzi A, Banwell B, Boyko A et al (2010) The management of multiple sclerosis in children: a European view. Mult Scler 16:1258–1267
Thompson AJ, Banwell BL, Barkhof F et al (2018) Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol 17:162–173
Baroncini D, Ghezzi A, Guaschino C et al (2022) MS Study Group of the Italian Neurological Society. Long-term follow-up (up to 11 years) of an Italian pediatric MS cohort treated with Natalizumab: a multicenter, observational study. Neurol Sci 43:6415–6423
Kornek B, Aboul-Enein F, Rostasy K et al (2013) Natalizumab therapy for highly active pediatric multiple sclerosis. JAMA Neurol 70:469–475
Margoni M, Rinaldi F, Riccardi A et al (2020) No evidence of disease activity including cognition (NEDA-3 plus) in naive pediatric multiple sclerosis patients treated with natalizumab. J Neurol 267:100–105
Acknowledgements
The authors are grateful to the patient’s parents for allowing this report and signing the informed consent.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethical approval
The patient’s parents provided written informed consent. The study was performed in agreement with the Declaration of Helsinki.
Conflict of interest
IRZ acted as an Advisory Board member of, and received funding and honoraria for speaking or consultation fees from Merck-Serono, Teva, Sanofi-Genzyme, Biogen, Genzyme, Novartis, Roche, Admirall. DP has received funding for traveling from Eisai, Jazz Pharmaceutical, Ecupharma, Neuraxpharm and UCBSS. SS, AN, AM and CA report no disclosures.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sotgiu, S., Nieddu, A., Pruna, D. et al. On a 5-year-old girl with multiple sclerosis treated with natalizumab. Neurol Sci 44, 2963–2965 (2023). https://doi.org/10.1007/s10072-023-06780-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-023-06780-2