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Fall risk is related to cognitive functioning in ambulatory multiple sclerosis patients

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A Correction to this article was published on 22 April 2023

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Abstract

Background and aims

Patients with multiple sclerosis (PwMS) may suffer severely from falling and gait disturbance. Cognitive dysfunction, a common condition in MS patients, may also increase falling rates, regardless of physical disability. We planned this study to determine the fall rate and risk factors in MS patients, follow patients for falls, and reveal the relationship between falls and cognitive dysfunction.

Methods

The study was conducted on 124 patients who have RRMS diagnoses. Patients' gait speed, simultaneous gait speed during other tasks, functions of the upper extremity, balance rating, and fear of falling were evaluated with dual-task Timed-Up-and-Go-3 versions (TUG, TUG-C, TUG-M), Timed 25 Foot Walk (T25WFT), Nine Hole Peg Test (9HPT), Berg Balance Scale (BBS) and Falls Efficacy Scale-International (FES-I) tests. Cognitive functions, fatigue levels, and quality of life were measured with the Symbol Digit Modalities Test (SDMT), Fatigue Severity Scale (FSS), and Multiple Sclerosis Quality of Life (MSQoL) test. Two groups were formed as "fallers" and "non-faller patients". We monitored the patients in six months period.

Results

Forty-six patients fell at least once in the last one year before the study began. Fallers were older, less educated, had lower SDMT scores and higher disability scores. Non-faller patients scored lower in FES-I, TUG, and FSS tests. SDMT scores showed statistically significant, linear, positive, and moderate correlation with BBS and 9HPT scores (r = 0.307, p = 0.038, and r = 0.320, p = 0.030, respectively).

Conclusion

We determined that advanced age, lower education level, and cognitive dysfunction adversely affect gait speed and balance. Among the fallers, those with lower SDMT and MoCA scores had higher falling rates. We determined that EDSS and BBS scores are predictive factors for falls in patients with MS. In conclusion, patients with cognitive impairment should be closely monitored for the risk of falling. Consideration of falls during follow-up examinations might be predictive of cognitive deterioration in patients with MS.

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Authors and Affiliations

  1. Department of Neurology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey

    Yaprak Ozum Unsal Bilgin & Asli Koskderelioglu

  2. Department of Neurology, Private Emotplus Hospital, Izmir, Turkey

    Muhtesem Gedizlioglu

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The original online version of this article was revised: The original article contains an error during online publication. In Material and methods under Study design and participants, “xxxxxx…” should be replace to "University of Health Sciences, Izmir Bozyaka Education and Research Hospital.

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Bilgin, Y.O.U., Koskderelioglu, A. & Gedizlioglu, M. Fall risk is related to cognitive functioning in ambulatory multiple sclerosis patients. Neurol Sci 44, 3233–3242 (2023). https://doi.org/10.1007/s10072-023-06770-4

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