Skip to main content
SpringerLink
Log in

Tacrolimus-induced akinetic mutism and persistent dysarthria following orthotopic liver transplantation

  • Letter to the Editor
  • Published:
Neurological Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Provenzani A, Santeusanio A, Mathis E, Notarbartolo M, Labbozzetta M, Poma P, Provenzani A, Polidori C, Vizzini G, Polidori P, D’Alessandro N (2013) Pharmacogenetic considerations for optimizing tacrolimus dosing in liver and kidney transplant patients. World J Gastroenterol 19(48):9156–9173

    Article  PubMed  PubMed Central  Google Scholar 

  2. Vearrier D, Simpson SE, Greenberg MI (2011) Mutism and persistent dysarthria due to tacrolimus-based immunosuppression following allogeneic liver transplantation. Am J Ther 18(6):e274–e276

    Article  PubMed  Google Scholar 

  3. Jin B, Kim GY, Cheon SM (2021) Tacrolimus-induced neurotoxicity from bipolar disorder to status epilepticus under the therapeutic serum level: a case report. BMC Neurol 21(1):448

    Article  PubMed  PubMed Central  Google Scholar 

  4. Najera JE, Alousi A, De Lima M, Ciurea SO (2013 Jan) Akinetic mutism-a serious complication to tacrolimus-based GVHD prophylaxis. Bone Marrow Transplant 48(1):157–158

    Article  CAS  PubMed  Google Scholar 

  5. Hategan A, Bourgeois JA (2015) Tacrolimus neurotoxicity and the role of the renin-angiotensin system. J Neuropsychiatry Clin Neurosci 27(2):e140–e141

    Article  PubMed  Google Scholar 

  6. Perdomo KT, Cabello MN, Saez MP et al (2012) Reversible acute encephalopathy with mutism, induced by calcineurin inhibitors after renal transplantation. J Nephrol 25(5):839–842

    Article  Google Scholar 

  7. Sato K, Miura Y, Marui Y et al (2015) Later onset of progressive speech impairment due to tacrolimus-associated leukoencephalopathy after kidney transplant. Int Urol Nephrol 47L:1437–1438

    Article  Google Scholar 

  8. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 30(2):239–245

    Article  CAS  PubMed  Google Scholar 

  9. Yamauchi A, Ieiri I, Kataoka Y, Tanabe M, Nishizaki T, Oishi R, Higuchi S, Otsubo K, Sugimachi K (2002) Neurotoxicity induced by tacrolimus after liver transplantation: relation to genetic polymorphisms of the ABCB1 (MDR1) gene. Transplant 74(4):571–572

    Article  CAS  Google Scholar 

  10. Boeve BF, Kimmel DW, Aronson AE, de Groen PC (1996) Dysarthria and apraxia of speech associated with FK-506 (tacrolimus). Mayo Clin Proc 71(10):969–972

    Article  CAS  PubMed  Google Scholar 

  11. Wijdicks EF (2001) Neurotoxicity of immunosuppressive drugs. Liver Transpl 7(11):937–942

    Article  CAS  PubMed  Google Scholar 

  12. Sierra-Hidalgo F, Martinez-Salio A, Moreno-Garcia S, de Pablo-Fernandez E, Correas-Callero E, Ruiz-Morales J (2009) Akinetic mutism induced by tacrolimus. Clin Neuropharmacol 32:293–294

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Pharmacy Service, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy

    Alessio Provenzani

  2. Neurology Unit, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy

    Vincenzina Lo Re

Authors
  1. Alessio Provenzani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vincenzina Lo Re
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alessio Provenzani.

Ethics declarations

Ethical approval

Not necessary. IRRB number: IRRB/25/22

Conflict of interests

The authors declare no competing interests.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Provenzani, A., Re, V.L. Tacrolimus-induced akinetic mutism and persistent dysarthria following orthotopic liver transplantation. Neurol Sci 44, 2983–2984 (2023). https://doi.org/10.1007/s10072-023-06760-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-023-06760-6

Search

Navigation