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The prognostic value of caveolin-1 levels in ischemic stroke patients after mechanical thrombectomy

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Abstract

Background and purpose

The impact of serum caveolin-1 (Cav-1) on clinical outcomes in patients after mechanical thrombectomy (MT) is unclear. We aimed to investigate the association between serum cav-1 levels and the 3-month functional outcome.

Methods

We prospectively enrolled and analyzed patients with an anterior circulation large vessel occlusion who underwent MT. Serum cav-1 concentrations were tested after admission. The primary outcome was a 90-day modified Rankin Scale score of 3–6.

Results

Of the 237 recruited patients (mean age, 69.7 ± 12.1 years; 152 male), 131 (55.3%) experienced a 90-day poor outcome. After adjustment for demographic characteristics and other covariates, patients with higher serum Cav-1 levels had a reduced risk of poor outcome at 3 months (Per 1-standard deviation increase; odd ratios [OR], 0.59; 95% confidence interval [CI], 0.39 − 0.89, P = 0.013). Elevated Cav-1 concentrations (Per 1-standard deviation increase; OR, 0.59; 95% CI, 0.40 − 0.88, P = 0.011) were significantly associated with a favorable shift in modified Rankin Scale score distribution. Similar results were confirmed when the Cav-1 levels were analyzed as a categorical variable. Furthermore, the restricted cubic spline showed a linear association between Cav-1 levels and 90-day poor outcome (P = 0.032 for linearity).

Conclusions

Increased serum Cav-1 levels were associated with improved prognosis at 3 months in ischemic stroke patients after MT, suggesting that Cav-1 may be a potential prognostic biomarker for ischemic stroke after reperfusion therapy.

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Data availability

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

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Author notes

  1. Qingguang Wang, Haiming Cao, and Yan E contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Jiangyin Hospital Affiliated to Nantong University, Jiangyin, 214400, Jiangsu, China

    Qingguang Wang

  2. Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210000, Jiangsu, China

    Haiming Cao, Yan E, Siyu Wang, Shuaiyu Chen, Huiwen Lian, Meng Wang, Junshan Zhou & Xiaohao Zhang

  3. Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210000, Jiangsu, China

    Yi Xie

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  1. Qingguang Wang
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  4. Siyu Wang
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Contributions

QW and XZ designed the study. QW, HC and YE interpreted data and wrote the manuscript. QW, HC, YE, SW, and SC did the statistical analyses. HL, MW, JZ and YX revised the manuscript. QW wrote the initial manuscript. XZ supervised the study. All authors have made an intellectual contribution to the manuscript and approved the submission.

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Correspondence to Xiaohao Zhang.

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The authors declare no competing interests.

Ethical approval and Informed consent statement

The study was approved by the ethics committee of Nanjing First Hospital, and written informed consents were obtained from all patients.

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Wang, Q., Cao, H., E, Y. et al. The prognostic value of caveolin-1 levels in ischemic stroke patients after mechanical thrombectomy. Neurol Sci 44, 2081–2086 (2023). https://doi.org/10.1007/s10072-023-06606-1

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  • DOI: https://doi.org/10.1007/s10072-023-06606-1

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