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Genetic analysis of the LRP10 gene in Chinese patients with Parkinson’s disease

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Abstract

Background

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by resting tremor, bradykinesia, muscle rigidity, and abnormal gait. The low-density lipoprotein receptor–related protein 10 (LRP10) was recently shown to be a causal gene for PD, and different ethnic cohorts have distinct frequencies and spectrum of LRP10 variants.

Methods

We sequenced the full coding regions and exon–intron boundaries of LRP10 in 129 patients with sporadic Chinese PD to further investigate the connection of LRP10 with PD in a sample of Chinese patients.

Results

In this study, we identified four potentially pathogenic mutations, including one novel mutation of p.Gly328Asp and three known mutations of p.Cys165Tyr, p.Arg230Trp, and p.Arg661His in four of the 129 Chinese patients with PD.

Conclusion

According to our study, the LRP10 gene may attribute to PD pathogenesis.

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Acknowledgements

We thank all the participants.

Funding

This study was supported by grants from the Shandong Provincial Natural Science Foundation (Nos. ZR2019ZD39 and ZR2020KH026), National Natural Science Foundation of China (Nos. 81800980 and 81972989).

Author information

Author notes

  1. Na Song, Yan Wang, and Liangxing Zhou contributed equally to this work.

Authors and Affiliations

  1. The Institute for Tissue Engineering and Regenerative Medicine, Laboratory for Stem Cell & Regenerative Medicine, Liaocheng University/Liaocheng People’s Hospital, Liaocheng, Shandong, 252000, China

    Na Song, Yan Wang, Mengpeng Li, Wei Wang, Yanming Liu, Xianjie Lu, Qingfa Chen, Nan Zhang & Fabin Han

  2. The Translational Research Laboratory for Stem Cell and Traditional Chinese Medicine, Innovation Institute for Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong, China

    Liangxing Zhou, Junli Zhang & Fabin Han

  3. Department of Dermatology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China

    Fan Wu

  4. Department of Occupational Disease, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China

    Yongjian Yan

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  1. Na Song
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Corresponding authors

Correspondence to Yongjian Yan or Fabin Han.

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This study was approved by the Ethical Review Committees of Liaocheng People’s Hospital.

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Song, N., Wang, Y., Zhou, L. et al. Genetic analysis of the LRP10 gene in Chinese patients with Parkinson’s disease. Neurol Sci 44, 905–912 (2023). https://doi.org/10.1007/s10072-022-06496-9

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