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Predominant motor neuron involvement as a manifestation of pathogenic (full range) ATXN3 mutations

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Availability of data and materials

The additional data that support the findings of this study are available from the corresponding author, ZKW, upon reasonable request.

References

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Funding

Gifts from the Donald G. and Jodi P. Heeringa Family.

Jaroslaw Dulski:

Employment: Medical University of Gdansk, Copernicus PL Ltd., MJ Jarosław Dulski.

Honoraria: VM Media Ltd., Radosław Lipiński 90 Consulting, Ipsen.

Grants: the Haworth Family Professorship in Neurodegenerative Diseases fund.

Alexandra Estela Soto Piña:

Employment: Universidad Autónoma del Estado de México

Rana Hanna Al-Shaikh:

Employment: Mayo Clinic Florida

Leonard Petrucelli:

Intellectual Property Rights: AAV-C9orf72 mice have been licensed.

pTD-43 antibody has been licensed.

Consultancies: Expansion Therapeutics.

Employment: Mayo Clinic Florida

Zbigniew K. Wszolek:

Intellectual Property Rights: Mayo Clinic and ZKW have a financial interest in technologies entitled, “Identification of Mutations in PARK8, a Locus for Familial Parkinson's Disease” and “Identification of a Novel LRRK2 Mutation, 6055G > A (G2019S), Linked to Autosomal Dominant Parkinsonism in Families from Several European Populations”. Those technologies have been licensed to a commercial entity, and to date, ZKW has received royalties < $1.500 through Mayo Clinic in accordance with its royalty sharing policies.

Consultancies: Vigil Neuroscience, Inc.

Advisory Boards: Vigil Neuroscience, Inc.

Employment: Mayo Clinic Florida

Honoraria: Polish Neurological Society—co-editor-in-chief of Neurologia i Neurochirurgia Polska

Grants: NIH/NIA and NIH/NINDS (1U19AG063911, FAIN: U19AG063911), Mayo Clinic Center for Regenerative Medicine, Mayo Clinic in Florida Focused Research Team Program, the gifts from the Donald G. and Jodi P. Heeringa Family, the Haworth Family Professorship in Neurodegenerative Diseases fund, and The Albertson Parkinson's Research Foundation. He serves as PI or Co-PI on Biohaven Pharmaceuticals, Inc. (BHV4157-206 and BHV3241-301), Neuraly, Inc. (NLY01-PD-1), and Vigil Neuroscience, Inc. (VGL101-01.001) grants.

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Authors and Affiliations

  1. Department of Neurology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA

    Jarosław Dulski, Rana Hanna Al-Shaikh & Zbigniew K. Wszolek

  2. Division of Neurological and Psychiatric Nursing, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland

    Jarosław Dulski

  3. Neurology Department, St Adalbert Hospital, Copernicus PL Ltd., Gdansk, Poland

    Jarosław Dulski

  4. Facultad de Medicina, Universidad Autónoma del Estado de México, Mexico, Mexico

    Alexandra Estela Soto Piña

  5. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA

    Rana Hanna Al-Shaikh & Leonard Petrucelli

  6. Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA

    Leonard Petrucelli

Authors
  1. Jarosław Dulski
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  2. Alexandra Estela Soto Piña
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  3. Rana Hanna Al-Shaikh
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  4. Leonard Petrucelli
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  5. Zbigniew K. Wszolek
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Corresponding author

Correspondence to Zbigniew K. Wszolek.

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All aspects of the research were approved by the Institutional Review Boards of Mayo Clinic.

Informed consent

Written informed consent was collected from the patient.

Consent to participate

Written informed consent was collected from the patient.

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The authors declare no competing interests.

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Dulski, J., Piña, A.E.S., Al-Shaikh, R.H. et al. Predominant motor neuron involvement as a manifestation of pathogenic (full range) ATXN3 mutations. Neurol Sci 44, 389–392 (2023). https://doi.org/10.1007/s10072-022-06410-3

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  • DOI: https://doi.org/10.1007/s10072-022-06410-3

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