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Primary central nervous system lymphoma in a patient with multiple sclerosis using fingolimod

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Abstract

Primary central nervous system lymphoma (PCNSL) is an uncommon lymphoproliferative disease associated with immunosuppression. Here, we report the case of a patient with multiple sclerosis, under treatment with fingolimod (FTY720, Gilenya) for 4 years, who developed this condition. Although the causal relationship cannot be established, there are cases in the literature that describe the appearance of lymphoma after the use of this medication. Considering the high mortality of PCNSL, epidemiological studies are necessary to establish a relationship between its arising and the use of immunosuppressants.

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Authors and Affiliations

  1. Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

    Matheus Bernardon Morillos & Alessandro Finkelsztejn

  2. Department of Neurology, Pontifícia Universidade Católica de São Paulo, São Paulo, Brazil

    Paulo Henrique Pires de Aguiar

  3. Department of Neurosurgery, Hospital Saúde, Caxias do Sul, Rio Grande do Sul, Brazil

    Paulo Roberto Franceschini

  4. Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

    Juliana Ávila Duarte

  5. Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2400, Bairro Santa Cecília, Porto Alegre, RS, CEP 90035-002, Brazil

    Cristian Daniel Piccini

Authors
  1. Matheus Bernardon Morillos
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  2. Paulo Henrique Pires de Aguiar
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  3. Paulo Roberto Franceschini
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  4. Juliana Ávila Duarte
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  5. Cristian Daniel Piccini
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  6. Alessandro Finkelsztejn
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Corresponding author

Correspondence to Cristian Daniel Piccini.

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This is a retrospective and observational case report and is not applicable for the ethics committee approval.

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Morillos, M.B., de Aguiar, P.H.P., Franceschini, P.R. et al. Primary central nervous system lymphoma in a patient with multiple sclerosis using fingolimod. Neurol Sci 44, 361–363 (2023). https://doi.org/10.1007/s10072-022-06367-3

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  • DOI: https://doi.org/10.1007/s10072-022-06367-3

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