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Functional brain changes in Parkinson’s disease: a whole brain ALE study

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Abstract

Background

Resting-state functional magnetic resonance imaging (rs-fMRI) was widely used as an effective tool in the diagnosis of neurodegenerative diseases. However, prior rs-fMRI studies reported inconsistent results for comparison between Parkinson’s disease (PD) and healthy controls (HC).

Methods

We searched studies published before December 2021 in databases (PubMed, Web of Science, and Google Scholar). An activation likelihood estimation (ALE) meta-analysis was made for functional changes in PD.

Results

The study finally included 25 studies (including 973 PD patients and 766 HC). PD patients showed reduced amplitude of low frequency fluctuations (ALFF) in the left superior temporal gyrus (STG), the left superior frontal gyrus (SFG), the left medial frontal gyrus (MFG), the left precuneus (PCUN), and the right lentiform nucleus, compared to HC. PD patients showed increased ALFF in the right SFG, the left superior parietal lobule (SPL), the left STG, the right fusiform gyrus, the left inferior temporal gyrus (ITG), and the right parahippocampal gyrus (PHG), compared to HC. PD patients showed reduced regional homogeneity (ReHo) in the right declive, the right MFG, the left culmen, and the left thalamus, compared to HC. PD patients showed increased ReHo in the right SFG, compared to HC. Additionally, PD patients showed reduced functional connectivity (FC) in the right posterior cingulate (PCG), compared to HC.

Conclusions

The present ALE analysis has confirmed functional deficits in motor-, emotion-, and cognition-related regions in PD. Deficits in these regions in rs-fMRI studies could play a role in early diagnosis of PD.

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Funding

This study was supported by the National Natural Science Foundation of China (No. 81901108; 81801075), the Special fund for basic scientific research operating expenses of Southeast University (No. 2242019K40256), Natural Science Foundation of Jiangsu Province (BK20180379), and Innovative Talents of Jiangsu Province Fundation.

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Authors and Affiliations

  1. Department of Neurology, Tianjin Huanhu Hospital, No. 6 Jizhao Road, Tianjin, 300222, China

    Lihua Gu

  2. Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, No. 87 Dingjiaqiao Road, Nanjing, Jiangsu, 210009, China

    Lihua Gu, Hao Shu, Hui Xu & Yanjuan Wang

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  1. Lihua Gu
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  2. Hao Shu
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  3. Hui Xu
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  4. Yanjuan Wang
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Correspondence to Lihua Gu.

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Gu, L., Shu, H., Xu, H. et al. Functional brain changes in Parkinson’s disease: a whole brain ALE study. Neurol Sci 43, 5909–5916 (2022). https://doi.org/10.1007/s10072-022-06272-9

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