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Serum TG/HDL-C level at the acute phase of ischemic stroke is associated with post-stroke cognitive impairment

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Abstract

Background

The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) bears a relation with poor outcomes of acute ischemic stroke (AIS), but the impact of serum TG/HDL-C level on post-stroke cognitive impairment (PSCI) remains unknown. We conducted this prospective study to explore the association between TG/HDL-C and PSCI.

Methods

Consecutive AIS patients from the Stroke Units of our hospital were prospectively enrolled between July 1, 2020, and June 30, 2021. Blood samples were collected within 24 h after admission. Cognition function was evaluated by the Montreal Cognitive Assessment (MoCA) at 3 months after stroke. We used logistic regression analyses to explore the relationship between TG/HDL-C and PSCI, and then used a receiver operating characteristic (ROC) analysis to assess the ability of acute TG/HDL-C for predicting PSCI.

Results

A total of 227 AIS patients were recruited. Compared with patients without PSCI, those with PSCI had a higher level of TG/HDL-C at admission (P < 0.01). The multivariate logistic regression analyses showed that TG/HDL-C level was independently associated with PSCI (P < 0.01). The area under the curve of the ROC for TG/HDL-C as predictor of PSCI was 0.701 (95%CI 0.635–0.768). The optimal cutoff value of TG/HDL-C to indicate PSCI was 1.564, which gave a sensitivity of 55.2% and specificity of 80.6%.

Conclusions

Our study demonstrated that a higher level of TG/HDL-C at the acute phase of ischemic stroke predicted the presence of PSCI at 3 months after stroke.

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Data availability

The data that support the findings of this study are available from Dingming Sun upon reasonable request.

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Funding

This work was supported by the Science and Technology Bureau of Yancheng (YK2019005).

Author information

Author notes

  1. Yongqing Cheng and Honghong Zhu contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, The Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of Yancheng, 166 Yulong West Road, Yancheng, Jiangsu, 224000, China

    Yongqing Cheng, Jin Chen, Lei Li, Changxia Liu, Yang Gao & Dingming Sun

  2. Department of Rheumatology and Immunology, The Yancheng Clinical College of Xuzhou Medical University, The First People’s Hospital of Yancheng, Yancheng, Jiangsu, 224000, China

    Honghong Zhu

Authors
  1. Yongqing Cheng
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Contributions

DMS, YG, and YQC designed the study. HHZ, YQC, JC, LL, and CXL conducted the research. YQC and HHZ wrote the paper and analyzed the data. All authors reviewed and approved the final version of the manuscript.

Corresponding authors

Correspondence to Yang Gao or Dingming Sun.

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Ethical approval

This study was conducted according to the protocol approved by the Human Subjects Research Ethics Board of The First People’s Hospital of Yancheng.

Informed consent

Written informed consent was obtained from all participants.

Conflict of Interest

The authors declare no competing interests.

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Cheng, Y., Zhu, H., Chen, J. et al. Serum TG/HDL-C level at the acute phase of ischemic stroke is associated with post-stroke cognitive impairment. Neurol Sci 43, 5977–5984 (2022). https://doi.org/10.1007/s10072-022-06267-6

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  • DOI: https://doi.org/10.1007/s10072-022-06267-6

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