Abstract
Background
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is one of the most common autoimmune peripheral neuropathies in adults. Membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS), and other nephropathy have been reported in CIDP patients and are possibly correlated to CIDP pathogenesis. This study reviewed the previously described cases of patients with CIDP and nephropathy in order to provide comprehensive evidence on the diagnosis and treatment regarding CIDP patients in the context of renal diseases.
Method
We reviewed our database to identify patients with CIDP and nephropathy. Online database including PubMed, EMBASE, and OVID were searched for relevant cases.
Results
We identified a total of 18 cases with CIDP and nephropathy, including 2 cases from our database and 16 ones from online searching. A predominance of male was observed [14 (77.8%)] with the mean age of 53.3 (standard deviation, SD: 16.6) years old. Almost all patients complained paresthesia in distal limbs (94.4%), except one only presented weakness of four extremities. Corticosteroids were prescribed for 14 (77.8%) patients, and 10 showed responsiveness. Three patients experienced relapses during the gradual tapering of steroids.
Conclusion
The same immune-mediated pathogenesis may be involved in CIDP and concomitant nephropathy. Male and sensory-predominant CIDP are red flags for complications of renal diseases in CIDP patients. Corticosteroids remain the first-line treatment for CIDP when complicated with renal diseases. Slower tapering or long-term maintenance of steroids may be beneficial for the prognosis of patients with CIDP and nephropathy.
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Data availability
All data analyzed during this study are included in published articles.
References
Peltier AC, Donofrio PD (2012) Chronic inflammatory demyelinating polyradiculoneuropathy: from bench to bedside. Semin Neurol 32(3):187–195
Reynolds J, Sachs G, Stavros K (2013) Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): clinical features, diagnosis, and current treatment strategies. R I Med J 2016 Dec 1 99(12):32–35
Van den Bergh PYK et al (2021) European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force-second revision. Eur J Neurol 28(11):3556–3583
Broers MC et al (2019) Incidence and prevalence of chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review and meta-analysis. Neuroepidemiology 52(3–4):161–172
Reinhard L, Stahl RAK, Hoxha E (2020) Is primary membranous nephropathy a complement mediated disease? Mol Immunol 128:195–204
Sinico RA et al (2016) Immunology of membranous nephropathy: from animal models to humans. Clin Exp Immunol 183(2):157–165
Witte AS, Burke JF (1987) Membranous glomerulonephritis associated with chronic progressive demyelinating neuropathy. Neurology 37(2):342–345
Donadio JV Jr, Burgess JH, Holley KE (1977) Membranous lupus nephropathy: a clinicopathologic study. Med (Baltimore) 56(6):527–36
Chen R et al (2021) Sjögren’s syndrome complicated with membranous nephropathy, a cause or coincidence? Int J Rheum Dis 24(8):1086–1094
Julio PR et al (2021) Chronic inflammatory demyelinating polyradiculoneuropathy associated with systemic lupus erythematosus. Semin Arthritis Rheum 51(1):158–165
Seeliger T et al (2019) Neuro-Sjögren: peripheral neuropathy with limb weakness in Sjögren’s syndrome. Front Immunol 10:1600
Alpaydın Baslo S et al (2021) CIDP and membranous nephropathy: a case with limited electrophysiological findings and a rare association. Neurol Sci 42(1):367–371
Girolami F et al (2010) Coincident chronic inflammatory demyelinating polyneuropathy and focal segmental glomerulosclerosis: a common autoimmunity? Clin Exp Nephrol 14(3):294–295
Souayah N et al (2008) Relapsing Guillain Barré Syndrome and nephrotic syndrome secondary to focal segmental glomerulosclerosis. J Neurol Sci 270(1–2):184–188
Lucchetta M et al (2015) Long-term plasma exchange in pediatric CIDP. J Clin Apher 30(6):364–366
Nishida Y et al (1998) Renal failure due to IgA (Berger) nephropathy with inflammatory demyelinating polyradiculoneuropathy. Nephron 80(1):123–124
Moher D et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097
Bukhari S et al (2020) Anti-neurofascin-associated nephrotic-range proteinuria in chronic inflammatory demyelinating polyneuropathy. Kidney Med 2(6):797–800
Taieb G et al (2019) “Neuro-renal syndrome” related to anti-contactin-1 antibodies. Muscle Nerve 59(3):E19-e21
Bolz S et al (2018) CIDP, myasthenia gravis, and membranous glomerulonephritis - three autoimmune disorders in one patient: a case report. BMC Neurol 18(1):113
Hashimoto Y et al (2018) Chronic inflammatory demyelinating polyneuropathy with concurrent membranous nephropathy: an anti-paranode and podocyte protein antibody study and literature survey. Front Neurol 9:997
Quek AM et al (2014) Acute-onset chronic inflammatory demyelinating polyneuropathy with focal segmental glomerulosclerosis. J Neurol Sci 341(1–2):139–143
Smyth S, Menkes DL (2008) Coincident membranous glomerulonephritis and chronic inflammatory demyelinating polyradiculoneuropathy: questioning the autoimmunity hypothesis. Muscle Nerve 37(1):130–135
Chen KH, Chang CT, Hung CC (2006) Glomerulonephritis associated with chronic inflammatory demyelinating polyneuropathy. Ren Fail 28(3):255–259
Emsley HC, Molloy J (2002) Inflammatory demyelinating polyradiculoneuropathy associated with membranous glomerulonephritis and thrombocytopaenia. Clin Neurol Neurosurg 105(1):23–26
Wu AD, Russell JA, Bouthout BA (2001) Chronic inflammatory demyelinating polyneuropathy and membranous glomerulonephropathy: report of two cases. J Clin Neuromuscul Dis 3(2):70–74
Henderson RD et al (2000) Chronic inflammatory demyelinating polyradiculoneuropathy and severe peripheral oedema: a renal explanation. J Clin Neurosci 7(2):148–149
Mobbs RJ, Tuck RR, Hurley B (2000) Chronic inflammatory demyelinating polyneuropathy associated with membranous glomerulonephritis: case report. J Clin Neurosci 7(5):454–455
Olbricht CJ et al (1993) Glomerulonephritis associated with inflammatory demyelinating polyradiculoneuropathy: a case report and review of the literature. Nephron 64(1):139–141
McGrogan A, Franssen CF, de Vries CS (2011) The incidence of primary glomerulonephritis worldwide: a systematic review of the literature. Nephrol Dial Transplant 26(2):414–430
Camargo CRS, Schoueri JHM, Alves BDCA, Veiga GRLD, Fonseca FLA, Bacci MR (1992) Uremic neuropathy: an overview of the current literature. Rev Assoc Med Bras 2019 Mar 65(3):469–474. https://doi.org/10.1590/1806-9282.65.3.469
Couser WG (2017) Primary membranous nephropathy. Clin J Am Soc Nephrol 12(6):983–997
Rosenberg AZ, Kopp JB (2017) Focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 12(3):502–517
Floege J, Amann K (2016) Primary glomerulonephritides. Lancet 387(10032):2036–2048
Gras V, Andréjak M, Decocq G (1999) Acute renal failure associated with intravenous immunoglobulins. Pharmacoepidemiol Drug Saf 8(Suppl 1):S73–S78
Malyszko J et al (2017) Nephrotoxicity of anticancer treatment. Nephrol Dial Transplant 32(6):924–936
van de Logt AE et al (2019) The anti-PLA2R antibody in membranous nephropathy: what we know and what remains a decade after its discovery. Kidney Int 96(6):1292–1302
Panjwani M, Truong LD, Eknoyan G (1996) Membranous glomerulonephritis associated with inflammatory demyelinating peripheral neuropathies. Am J Kidney Dis 27(2):279–283
Rezania K, Gundogdu B, Soliven B (2004) Pathogenesis of chronic inflammatory demyelinating polyradiculoneuropathy. Front Biosci 9:939–45
Reid RA et al (1994) Identification and characterization of the human cell adhesion molecule contactin. Brain Res Mol Brain Res 21(1–2):1–8
Filippone EJ (2014) Idiopathic membranous nephropathy and IgG4: an interesting relationship. Clin Nephrol 82(1):7–15
Cortese A et al (2020) Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: clinical relevance of IgG isotype. Neurol Neuroimmunol Neuroinflamm 7:1
Santoro D, Debiec H, Longhitano E, Torreggiani M, Barreca A, Vegezzi E, Mazzeo A, Russo M, Piccoli GB, Toscano A, Ronco P (2021) Contactin 1, a potential new antigen target in membranous nephropathy: a case report. Am J Kidney Dis 2021 Nov 8:S0272–6386(21)00950–1. https://doi.org/10.1053/j.ajkd.2021.08.025
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Authors would like to thank all the authors of the original articles.
Funding
This study has been supported by the CAMS Innovation Fund for Medical Sciences (CIFMS 2021-I2M-1–003) and the Beijing Natural Science Foundation (7202158).
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Hu, N., Niu, J. & Liu, M. Chronic inflammatory demyelinating polyradiculoneuropathy concomitant with nephropathy. Neurol Sci 43, 5885–5898 (2022). https://doi.org/10.1007/s10072-022-06215-4
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DOI: https://doi.org/10.1007/s10072-022-06215-4