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The prevalence of osteoporosis/osteopenia in patients with multiple sclerosis (MS): a systematic review and meta-analysis

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Abstract  

Background

The prevalence of osteoporosis is reported differently. We designed this systematic review and meta-analysis to estimate pooled prevalence of osteoporosis and osteopenia in patients with MS.

Methods

Independently, two researchers searched PubMed, Scopus, EMBASE, Web of Science, and google scholar along with gray literature (conference abstracts and references of the references) up to March 2021. We collected data regarding first author, country of origin, number of enrolled patients, number cases with osteoporosis/ osteopenia, mean age, F/M ratio, mean EDSS, and mean duration of the disease.

Results

Literature search revealed 847 articles and 658 remained after deleting duplicates. Finally, 29 original articles and 6 conference papers remained for meta-analysis. A total of 13,906 patients were evaluated. The pooled prevalence of osteoporosis was 17% (95% CI: 14–20%) (I2 = 90.4%, p < 0.001). The pooled prevalence of osteopenia was 43% (95% CI: 35–51%) (I2 = 97.9%, p < 0.001).

Conclusion

Osteoporosis/osteopenia should be considered in patients with MS.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Sina & Imam Khomeini Hospital, Tehran Medical University, Tehran, Iran

    Mohaddeseh Azadvari

  2. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

    Omid Mirmosayyeb

  3. Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran

    Omid Mirmosayyeb

  4. Department of Physical Medicine and Rehabilitation, Imam Khomeini Hospital, Tehran Medical University, Tehran, Iran

    Maryam Hosseini & Seyede Zahra Emami Razavi

  5. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Saeed Vaheb

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  1. Mohaddeseh Azadvari
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  2. Omid Mirmosayyeb
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  3. Maryam Hosseini
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  4. Saeed Vaheb
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  5. Seyede Zahra Emami Razavi
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Correspondence to Seyede Zahra Emami Razavi.

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Azadvari, M., Mirmosayyeb, O., Hosseini, M. et al. The prevalence of osteoporosis/osteopenia in patients with multiple sclerosis (MS): a systematic review and meta-analysis. Neurol Sci 43, 3879–3892 (2022). https://doi.org/10.1007/s10072-022-05871-w

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  • DOI: https://doi.org/10.1007/s10072-022-05871-w

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