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Neuro-oncology and supportive care: the role of the neurologist

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Abstract

The diagnosis of a brain tumor is a life-changing event for patients and their families. Despite numerous treatment advances, malignant brain tumors are universally incurable and long-term survival is limited. Treatment response, prognosis, and survival depend on underlying histopathology and recently defined molecular features. Patients suffer from a disproportionately high symptom burden throughout the disease trajectory and at the end of life. Pronounced neurologic decline and psychological distress significantly impair quality of life (QoL) and impose high supportive care needs relative to other systemic cancers. Palliative interventions addressing brain tumor-specific symptoms, such as seizures, cognitive dysfunction, and headaches, are paramount to maintaining QoL. In the terminal phase of illness, most brain tumor patients lose the ability to communicate and participate in end-of-life decision-making. The benefits of advance care planning and early integration of specialized palliative care are well-established in other systemic cancers and have received wider recognition in neuro-oncology. We review how to approach neurological symptoms in brain tumor patients, as well as address prognosis and advance care planning with the goal of improving QoL for patients and caregivers.

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References

  1. Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C (2017) Barnholtz-Sloan JS (2020) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017. Neuro Oncol 22:iv1–iv96. https://doi.org/10.1093/neuonc/noaa200

    Article  Google Scholar 

  2. Poon MTC, Sudlow CLM, Figueroa JD, Brennan PM (2020) Longer-term (>/= 2 years) survival in patients with glioblastoma in population-based studies pre- and post-2005: a systematic review and meta-analysis. Sci Rep 10:11622. https://doi.org/10.1038/s41598-020-68011-4

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 23:1231–1251. https://doi.org/10.1093/neuonc/noab106

    Article  CAS  PubMed  Google Scholar 

  4. Stupp R, Taillibert S, Kanner A, Read W, Steinberg D, Lhermitte B, Toms S, Idbaih A, Ahluwalia MS, Fink K, Di Meco F, Lieberman F, Zhu JJ, Stragliotto G, Tran D, Brem S, Hottinger A, Kirson ED, Lavy-Shahaf G, Weinberg U, Kim CY, Paek SH, Nicholas G, Bruna J, Hirte H, Weller M, Palti Y, Hegi ME, Ram Z (2017) Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial. JAMA 318:2306–2316. https://doi.org/10.1001/jama.2017.18718

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Walbert T, Khan M (2014) End-of-life symptoms and care in patients with primary malignant brain tumors: a systematic literature review. J Neurooncol 117:217–224. https://doi.org/10.1007/s11060-014-1393-6

    Article  PubMed  Google Scholar 

  6. Au TH, Willis C, Reblin M, Peters KB, Nghiemphu PL, Taylor JW, Colman H, Cohen AL, Ormond DR, Chakravarti A, Willmarth N, Menon J, Ma J, Bauer H, Watanabe AH, Ulrich CM, Singh P, Marshall A, Korytowsky B, Stenehjem D, Brixner D (2021) Caregiver burden by treatment and clinical characteristics of patients with glioblastoma. Support Care Cancer. https://doi.org/10.1007/s00520-021-06514-0

    Article  PubMed  PubMed Central  Google Scholar 

  7. Pace A, Dirven L, Koekkoek JAF, Golla H, Fleming J, Rudà R, Marosi C, Le Rhun E, Grant R, Oliver K, Oberg I, Bulbeck HJ, Rooney AG, Henriksson R, Pasman HRW, Oberndorfer S, Weller M, Taphoorn MJB (2017) European Association for Neuro-Oncology (EANO) guidelines for palliative care in adults with glioma. Lancet Oncol 18:e330–e340. https://doi.org/10.1016/s1470-2045(17)30345-5

    Article  PubMed  Google Scholar 

  8. Oliver DJ, Borasio GD, Caraceni A, de Visser M, Grisold W, Lorenzl S, Veronese S, Voltz R (2016) A consensus review on the development of palliative care for patients with chronic and progressive neurological disease. Eur J Neurol 23:30–38. https://doi.org/10.1111/ene.12889

    Article  PubMed  CAS  Google Scholar 

  9. Armstrong TS, Vera-Bolanos E, Acquaye AA, Gilbert MR, Ladha H, Mendoza T (2016) The symptom burden of primary brain tumors: evidence for a core set of tumor- and treatment-related symptoms. Neuro Oncol 18:252–260. https://doi.org/10.1093/neuonc/nov166

    Article  PubMed  Google Scholar 

  10. Walbert T, Glantz M, Schultz L, Puduvalli VK (2016) Impact of provider level, training and gender on the utilization of palliative care and hospice in neuro-oncology: a North-American survey. J Neurooncol 126:337–345. https://doi.org/10.1007/s11060-015-1973-0

    Article  PubMed  Google Scholar 

  11. Philip J, Collins A, Brand C, Sundararajan V, Lethborg C, Gold M, Lau R, Moore G, Murphy M (2018) A proposed framework of supportive and palliative care for people with high-grade glioma. Neuro Oncol 20:391–399. https://doi.org/10.1093/neuonc/nox140

    Article  PubMed  Google Scholar 

  12. Diamond EL, Russell D, Kryza-Lacombe M, Bowles KH, Applebaum AJ, Dennis J, DeAngelis LM, Prigerson HG (2016) Rates and risks for late referral to hospice in patients with primary malignant brain tumors. Neuro Oncol 18:78–86. https://doi.org/10.1093/neuonc/nov156

    Article  PubMed  Google Scholar 

  13. Dropcho EJ (2010) Neurotoxicity of cancer chemotherapy. Semin Neurol 30:273–286. https://doi.org/10.1055/s-0030-1255217

    Article  PubMed  Google Scholar 

  14. Taal W, Brandsma D, de Bruin HG, Bromberg JE, Swaak-Kragten AT, Smitt PA, van Es CA, van den Bent MJ (2008) Incidence of early pseudo-progression in a cohort of malignant glioma patients treated with chemoirradiation with temozolomide. Cancer 113:405–410. https://doi.org/10.1002/cncr.23562

    Article  PubMed  CAS  Google Scholar 

  15. Kumar AJ, Leeds NE, Fuller GN, Van Tassel P, Maor MH, Sawaya RE, Levin VA (2000) Malignant gliomas: MR imaging spectrum of radiation therapy- and chemotherapy-induced necrosis of the brain after treatment. Radiology 217:377–384. https://doi.org/10.1148/radiology.217.2.r00nv36377

    Article  PubMed  CAS  Google Scholar 

  16. Gonzalez J, Kumar AJ, Conrad CA, Levin VA (2007) Effect of bevacizumab on radiation necrosis of the brain. Int J Radiat Oncol Biol Phys 67:323–326. https://doi.org/10.1016/j.ijrobp.2006.10.010

    Article  PubMed  CAS  Google Scholar 

  17. Dietrich J, Rao K, Pastorino S, Kesari S (2011) Corticosteroids in brain cancer patients: benefits and pitfalls. Expert Rev Clin Pharmacol 4:233–242. https://doi.org/10.1586/ecp.11.1

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Lee EQ, Muzikansky A, Drappatz J, Kesari S, Wong ET, Fadul CE, Reardon DA, Norden AD, Nayak L, Rinne ML, Alexander BM, Arvold ND, Doherty L, Stefanik J, LaFrankie D, Ruland SF, Pulverenti J, Smith KH, Gaffey SC, Hammond S, Wen PY (2016) A randomized, placebo-controlled pilot trial of armodafinil for fatigue in patients with gliomas undergoing radiotherapy. Neuro Oncol 18:849–854. https://doi.org/10.1093/neuonc/now007

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Rietjens JA, Korfage IJ, Dunleavy L, Preston NJ, Jabbarian LJ, Christensen CA, de Brito M, Bulli F, Caswell G, Cerv B, van Delden J, Deliens L, Gorini G, Groenvold M, Houttekier D, Ingravallo F, Kars MC, Lunder U, Miccinesi G, Mimic A, Paci E, Payne S, Polinder S, Pollock K, Seymour J, Simonic A, Johnsen AT, Verkissen MN, de Vries E, Wilcock A, Zwakman M, van der Heide PA (2016) Advance care planning–a multi-centre cluster randomised clinical trial: the research protocol of the ACTION study. BMC Cancer 16:264. https://doi.org/10.1186/s12885-016-2298-x

    Article  PubMed  PubMed Central  Google Scholar 

  20. Wasade VS, Viarasilpa T, Balki I, Osman G, Gaddam A, Dharaiya D, Pellumbi N, Snyder J, Walbert T, Spanaki M, Schultz L (2020) Effect of seizure timing on long-term survival in patients with brain tumor. Epilepsy & behav : E&B 111:107307. https://doi.org/10.1016/j.yebeh.2020.107307

    Article  Google Scholar 

  21. van Breemen MS, Wilms EB, Vecht CJ (2007) Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management. Lancet Neurol 6:421–430. https://doi.org/10.1016/s1474-4422(07)70103-5

    Article  PubMed  Google Scholar 

  22. Maschio M, Beghi E, Casazza MML, Colicchio G, Costa C, Banfi P, Quadri S, Aloisi P, Giallonardo AT, Buttinelli C, Pauletto G, Striano S, Salmaggi A, Terenzi R, Daniele O, Crichiutti G, Paladin F, Rossi R, Prato G, Vigevano F, De Simone R, Ricci F, Saladini M, Monti F, Casellato S, Zanoni T, Giannarelli D, Avanzini G, Aguglia U, Group BS (2017) Patterns of care of brain tumor-related epilepsy. A cohort study done in Italian Epilepsy Center. PLoS ONE 12:e0180470. https://doi.org/10.1371/journal.pone.0180470

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  23. Marcuse LV, Lancman G, Demopoulos A, Fields M (2014) Nonconvulsive status epilepticus in patients with brain tumors. Seizure 23:542–547. https://doi.org/10.1016/j.seizure.2014.04.003

    Article  PubMed  Google Scholar 

  24. Ruda R, Bello L, Duffau H, Soffietti R (2012) Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments. Neuro Oncol 14(Suppl 4):iv55-64. https://doi.org/10.1093/neuonc/nos199

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  25. Vecht CJ, Kerkhof M, Duran-Pena A (2014) Seizure prognosis in brain tumors: new insights and evidence-based management. Oncologist 19:751–759. https://doi.org/10.1634/theoncologist.2014-0060

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  26. Weller M, Stupp R, Wick W (2012) Epilepsy meets cancer: when, why, and what to do about it? Lancet Oncol 13:e375-382. https://doi.org/10.1016/s1470-2045(12)70266-8

    Article  PubMed  Google Scholar 

  27. Gallagher P, Leach JP, Grant R (2014) Time to focus on brain tumor-related epilepsy trials. Neurooncol Pract 1:123–133. https://doi.org/10.1093/nop/npu010

    Article  PubMed  PubMed Central  Google Scholar 

  28. Pace A, Villani V, Di Lorenzo C, Guariglia L, Maschio M, Pompili A, Carapella CM (2013) Epilepsy in the end-of-life phase in patients with high-grade gliomas. J Neurooncol 111:83–86. https://doi.org/10.1007/s11060-012-0993-2

    Article  PubMed  Google Scholar 

  29. Walbert T, Harrison RA, Schiff D, Avila EK, Chen M, Kandula P, Lee JW, Le Rhun E, Stevens GHJ, Vogelbaum MA, Wick W, Weller M, Wen PY, Gerstner ER (2021) SNO and EANO practice guideline update: anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. Neuro Oncol. https://doi.org/10.1093/neuonc/noab152

    Article  PubMed  PubMed Central  Google Scholar 

  30. Dewan MC, Thompson RC, Kalkanis SN, Barker FG 2nd, Hadjipanayis CG (2017) Prophylactic antiepileptic drug administration following brain tumor resection: results of a recent AANS/CNS Section on Tumors survey. J Neurosurg 126:1772–1778. https://doi.org/10.3171/2016.4.JNS16245

    Article  PubMed  Google Scholar 

  31. Fonkem E, Bricker P, Mungall D, Aceves J, Ebwe E, Tang W, Kirmani B (2013) The role of levetiracetam in treatment of seizures in brain tumor patients. Front Neurol 4:153. https://doi.org/10.3389/fneur.2013.00153

    Article  PubMed  PubMed Central  Google Scholar 

  32. Maschio M, Maialetti A, Mocellini C, Domina E, Pauletto G, Costa C, Mascia A, Romoli M, Giannarelli D (2020) Effect of brivaracetam on efficacy and tolerability in patients with brain tumor-related epilepsy: a retrospective multicenter study. Front Neurol 11:813. https://doi.org/10.3389/fneur.2020.00813

    Article  PubMed  PubMed Central  Google Scholar 

  33. Vecht C, Duran-Pena A, Houillier C, Durand T, Capelle L, Huberfeld G (2017) Seizure response to perampanel in drug-resistant epilepsy with gliomas: early observations. J Neurooncol 133:603–607. https://doi.org/10.1007/s11060-017-2473-1

    Article  PubMed  CAS  Google Scholar 

  34. Giammalva GR, Iacopino DG, Azzarello G, Gaggiotti C, Graziano F, Guli C, Pino MA, Maugeri R (2018) End-of-life care in high-grade glioma patients. The Palliative and Supportive Perspective. Brain Sci 8(7):125. https://doi.org/10.3390/brainsci8070125

  35. Koekkoek JA, Postma TJ, Heimans JJ, Reijneveld JC, Taphoorn MJ (2016) Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study. Support Care Cancer 24:1633–1638. https://doi.org/10.1007/s00520-015-2930-3

    Article  PubMed  Google Scholar 

  36. Loghin M, Levin VA (2006) Headache related to brain tumors. Curr Treat Options Neurol 8:21–32. https://doi.org/10.1007/s11940-996-0021-y

    Article  PubMed  Google Scholar 

  37. Nelson S, Taylor LP (2014) Headaches in brain tumor patients: primary or secondary? Headache 54:776–785. https://doi.org/10.1111/head.12326

    Article  PubMed  Google Scholar 

  38. Vázquez-Barquero A, Ibáñez FJ, Herrera S, Izquierdo JM, Berciano J, Pascual J (1994) Isolated headache as the presenting clinical manifestation of intracranial tumors: a prospective study. Cephalalgia 14:270–272. https://doi.org/10.1046/j.1468-2982.1994.1404270.x

    Article  PubMed  Google Scholar 

  39. Schankin CJ, Ferrari U, Reinisch VM, Birnbaum T, Goldbrunner R, Straube A (2007) Characteristics of brain tumour-associated headache. Cephalalgia 27:904–911. https://doi.org/10.1111/j.1468-2982.2007.01368.x

    Article  PubMed  CAS  Google Scholar 

  40. Forsyth PA, Posner JB (1993) Headaches in patients with brain tumors: a study of 111 patients. Neurology 43:1678–1683. https://doi.org/10.1212/wnl.43.9.1678

    Article  PubMed  CAS  Google Scholar 

  41. Purdy RA, Kirby S (2004) Headaches and brain tumors. Neurol Clin 22:39–53. https://doi.org/10.1016/s0733-8619(03)00099-9

    Article  PubMed  Google Scholar 

  42. Pfund Z, Szapáry L, Jászberényi O, Nagy F, Czopf J (1999) Headache in intracranial tumors. Cephalalgia 19:787–790; discussion 765. https://doi.org/10.1046/j.1468-2982.1999.1909787.x

  43. Goffaux P, Fortin D (2010) Brain tumor headaches: from bedside to bench. Neurosurgery 67:459–466. https://doi.org/10.1227/01.Neu.0000372092.96124.E6

    Article  PubMed  Google Scholar 

  44. Lutman B, Bloom J, Nussenblatt B, Romo V (2018) A contemporary perspective on the management of post-craniotomy headache and pain. Curr Pain Headache Rep 22:69. https://doi.org/10.1007/s11916-018-0722-4

    Article  PubMed  Google Scholar 

  45. The International Classification of Headache Disorders (2013) 3rd edition (beta version). Cephalalgia 33:629–808. https://doi.org/10.1177/0333102413485658

    Article  Google Scholar 

  46. Soumekh B, Levine SC, Haines SJ, Wulf JA (1996) Retrospective study of postcraniotomy headaches in suboccipital approach: diagnosis and management. Am J Otol 17:617–619

    PubMed  CAS  Google Scholar 

  47. Gee JR, Ishaq Y, Vijayan N (2003) Postcraniotomy headache. Headache 43:276–278. https://doi.org/10.1046/j.1526-4610.2003.03053.x

    Article  PubMed  Google Scholar 

  48. Flexman AM, Ng JL, Gelb AW (2010) Acute and chronic pain following craniotomy. Curr Opin Anaesthesiol 23:551–557. https://doi.org/10.1097/ACO.0b013e32833e15b9

    Article  PubMed  Google Scholar 

  49. Vegh T (2013) Diclofenac administered before skull operations reduces the severity of headache after the intervention, NCT01907984. https://clinicaltrials.gov/ct2/show/NCT01907984. Accessed September 29 2021

  50. MacKenzie HM, Teasell R, Miller TA, Sequeira K (2015) Peri-incisional botulinum toxin for chronic postcraniotomy headache after traumatic brain injury: a case series. PM R 7:785–788. https://doi.org/10.1016/j.pmrj.2015.02.015

    Article  PubMed  Google Scholar 

  51. Valentinis L, Tuniz F, Valent F, Mucchiut M, Little D, Skrap M, Bergonzi P, Zanchin G (2010) Headache attributed to intracranial tumours: a prospective cohort study. Cephalalgia 30:389–398. https://doi.org/10.1111/j.1468-2982.2009.01970.x

    Article  PubMed  CAS  Google Scholar 

  52. Kahn LH, Alderfer RJ, Graham DJ (1997) Seizures reported with tramadol Jama 278:1661

    PubMed  CAS  Google Scholar 

  53. Perloff MD (2015) Practical considerations in opioid use for brain neoplasm. Contin (Minneapolis, Minn) 21:480–486. https://doi.org/10.1212/01.CON.0000464183.35322.5f

    Article  Google Scholar 

  54. Bennett SR, Cruickshank G, Lindenmeyer A, Morris SR (2016) Investigating the impact of headaches on the quality of life of patients with glioblastoma multiforme: a qualitative study. BMJ Open 6:e011616. https://doi.org/10.1136/bmjopen-2016-011616

    Article  PubMed  PubMed Central  Google Scholar 

  55. Noll KR, Walbert T, Wefel JS (2020) Impaired neurocognitive function in glioma patients: from pathophysiology to novel intervention strategies. Curr Opin Neurol 33:716–722. https://doi.org/10.1097/WCO.0000000000000865

    Article  PubMed  Google Scholar 

  56. Coomans MB, van der Linden SD, Gehring K, Taphoorn MJB (2019) Treatment of cognitive deficits in brain tumour patients: current status and future directions. Curr Opin Oncol 31:540–547. https://doi.org/10.1097/CCO.0000000000000581

    Article  PubMed  PubMed Central  Google Scholar 

  57. Noll KR, Sullaway C, Ziu M, Weinberg JS, Wefel JS (2015) Relationships between tumor grade and neurocognitive functioning in patients with glioma of the left temporal lobe prior to surgical resection. Neuro Oncol 17:580–587. https://doi.org/10.1093/neuonc/nou233

    Article  PubMed  Google Scholar 

  58. Wefel JS, Noll KR, Scheurer ME (2016) Neurocognitive functioning and genetic variation in patients with primary brain tumours. Lancet Oncol 17:e97–e108. https://doi.org/10.1016/s1470-2045(15)00380-0

    Article  PubMed  PubMed Central  Google Scholar 

  59. Cordes MC, Scherwath A, Ahmad T, Cole AM, Ernst G, Oppitz K, Lanfermann H, Bremer M, Steinmann D (2014) Distress, anxiety and depression in patients with brain metastases before and after radiotherapy. BMC Cancer 14:731. https://doi.org/10.1186/1471-2407-14-731

    Article  PubMed  PubMed Central  Google Scholar 

  60. McTyre E, Scott J, Chinnaiyan P (2013) Whole brain radiotherapy for brain metastasis. Surg Neurol Int 4:S236-244. https://doi.org/10.4103/2152-7806.111301

    Article  PubMed  PubMed Central  Google Scholar 

  61. Marsh JC, Godbole R, Diaz AZ, Gielda BT, Turian JV (2011) Sparing of the hippocampus, limbic circuit and neural stem cell compartment during partial brain radiotherapy for glioma: a dosimetric feasibility study. J Med Imaging Radiat Oncol 55:442–449. https://doi.org/10.1111/j.1754-9485.2011.02282.x

    Article  PubMed  Google Scholar 

  62. Brown PD, Pugh S, Laack NN, Wefel JS, Khuntia D, Meyers C, Choucair A, Fox S, Suh JH, Roberge D, Kavadi V, Bentzen SM, Mehta MP, Watkins-Bruner D, Radiation Therapy Oncology G (2013) Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial. Neuro Oncol 15:1429–1437. https://doi.org/10.1093/neuonc/not114

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  63. Rodríguez de Dios N, Couñago F, Murcia-Mejía M, Rico-Oses M, Calvo-Crespo P, Samper P, Vallejo C, Luna J, Trueba I, Sotoca A, Cigarral C, Farré N, Manero RM, Durán X, Gispert JD, Sánchez-Benavides G, Rognoni T, Torrente M, Capellades J, Jiménez M, Cabada T, Blanco M, Alonso A, Martínez-San Millán J, Escribano J, González B, López-Guerra JL (2021) Randomized phase III trial of prophylactic cranial irradiation with or without hippocampal avoidance for small-cell lung cancer (PREMER): a GICOR-GOECP-SEOR study. J Clin Oncol 39:3118–3127. https://doi.org/10.1200/jco.21.00639

    Article  PubMed  Google Scholar 

  64. Rapp SR, Case LD, Peiffer A, Naughton MM, Chan MD, Stieber VW, Moore DF Jr, Falchuk SC, Piephoff JV, Edenfield WJ, Giguere JK, Loghin ME, Shaw EG (2015) Donepezil for irradiated brain tumor survivors: a phase III randomized placebo-controlled clinical trial. J Clin Oncol 33:1653–1659. https://doi.org/10.1200/JCO.2014.58.4508

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  65. Fried TR, Bradley EH, Towle VR, Allore H (2002) Understanding the treatment preferences of seriously ill patients. N Engl J Med 346:1061–1066. https://doi.org/10.1056/NEJMsa012528

    Article  PubMed  Google Scholar 

  66. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ (2010) Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 363:733–742. https://doi.org/10.1056/NEJMoa1000678

    Article  PubMed  CAS  Google Scholar 

  67. Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, Firn JI, Paice JA, Peppercorn JM, Phillips T, Stovall EL, Zimmermann C, Smith TJ (2017) Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 35:96–112. https://doi.org/10.1200/JCO.2016.70.1474

    Article  PubMed  Google Scholar 

  68. The Lancet N (2021) Editorial: New hope for advancing neuropalliative care. The Lancet Neurology 20(6):409. https://doi.org/10.1016/s1474-4422(21)00142-3

  69. Oliver D, Borasio GD, Veronese S, Voltz R, Lorenzl S, Hepgul N (2020) Current collaboration between palliative care and neurology: a survey of clinicians in Europe. BMJ Support Palliat Care. https://doi.org/10.1136/bmjspcare-2020-002322

    Article  PubMed  Google Scholar 

  70. Creutzfeldt CJ, Kluger B, Kelly AG, Lemmon M, Hwang DY, Galifianakis NB, Carver A, Katz M, Curtis JR, Holloway RG (2018) Neuropalliative care: priorities to move the field forward. Neurology 91:217–226. https://doi.org/10.1212/WNL.0000000000005916

    Article  PubMed  PubMed Central  Google Scholar 

  71. Forst D, Adams E, Nipp R, Martin A, El-Jawahri A, Aizer A, Jordan JT (2018) Hospice utilization in patients with malignant gliomas. Neuro Oncol 20:538–545. https://doi.org/10.1093/neuonc/nox196

    Article  PubMed  Google Scholar 

  72. Pace A, Koekkoek JAF, van den Bent MJ, Bulbeck HJ, Fleming J, Grant R, Golla H, Henriksson R, Kerrigan S, Marosi C, Oberg I, Oberndorfer S, Oliver K, Pasman HRW, Le Rhun E, Rooney AG, Ruda R, Veronese S, Walbert T, Weller M, Wick W, Taphoorn MJB, Dirven L (2020) Determining medical decision-making capacity in brain tumor patients: why and how? Neurooncol Pract 7:599–612. https://doi.org/10.1093/nop/npaa040

    Article  PubMed  PubMed Central  Google Scholar 

  73. Fritz L, Dirven L, Reijneveld JC, Koekkoek JA, Stiggelbout AM, Pasman HR, Taphoorn MJ (2016) Advance care planning in glioblastoma patients. Cancers (Basel) 8https://doi.org/10.3390/cancers8110102

  74. Chiarchiaro J, Buddadhumaruk P, Arnold RM, White DB (2015) Prior advance care planning is associated with less decisional conflict among surrogates for critically ill patients. Ann Am Thorac Soc 12:1528–1533. https://doi.org/10.1513/AnnalsATS.201504-253OC

    Article  PubMed  PubMed Central  Google Scholar 

  75. Sizoo EM, Pasman HR, Dirven L, Marosi C, Grisold W, Stockhammer G, Egeter J, Grant R, Chang S, Heimans JJ, Deliens L, Reijneveld JC, Taphoorn MJ (2014) The end-of-life phase of high-grade glioma patients: a systematic review. Support Care Cancer 22:847–857. https://doi.org/10.1007/s00520-013-2088-9

    Article  PubMed  Google Scholar 

  76. Chochinov HM (2006) Dying, dignity, and new horizons in palliative end-of-life care. CA Cancer J Clin 56:84–103; quiz 104–105. https://doi.org/10.3322/canjclin.56.2.84

  77. Goswami P (2021) Advance care planning and end-of-life communications: practical tips for oncology advanced practitioners. J Adv Pract Oncol 12:89–95. https://doi.org/10.6004/jadpro.2021.12.1.7

    Article  PubMed  PubMed Central  Google Scholar 

  78. Cottrell L, Economos G, Evans C, Silber E, Burman R, Nicholas R, Farsides B, Ashford S, Koffman JS (2020) A realist review of advance care planning for people with multiple sclerosis and their families. PLoS ONE 15:e0240815. https://doi.org/10.1371/journal.pone.0240815

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  79. Gofton TE, Chum M, Schulz V, Gofton BT, Sarpal A, Watling C (2018) Challenges facing palliative neurology practice: a qualitative analysis. J Neurol Sci 385:225–231. https://doi.org/10.1016/j.jns.2017.12.008

    Article  PubMed  CAS  Google Scholar 

  80. Walbert T, Puduvalli VK, Taphoorn MJB, Taylor AR, Jalali R (2015) International patterns of palliative care in neuro-oncology: a survey of physician members of the Asian Society for Neuro-Oncology, the European Association of Neuro-Oncology, and the Society for Neuro-Oncology. Neurooncol Pract 2:62–69. https://doi.org/10.1093/nop/npu037

    Article  PubMed  PubMed Central  Google Scholar 

  81. Parker G (2007) Patients’ perceptions of palliative care: a pilot study. Palliat Med 21:59–60. https://doi.org/10.1177/0269216306073132

    Article  PubMed  Google Scholar 

  82. Haider SA, Asmaro K, Kalkanis SN, Lee IY, Bazydlo M, Nerenz DR, Salloum RG, Snyder J, Walbert T (2020) The economic impact of glioma survivorship: the cost of care from a patient perspective. Neurology 95:e1575–e1581. https://doi.org/10.1212/wnl.0000000000010263

    Article  PubMed  Google Scholar 

  83. Page MS, Chang SM (2017) Creating a caregiver program in neuro-oncology. Neurooncol Pract 4:116–122. https://doi.org/10.1093/nop/npw019

    Article  PubMed  Google Scholar 

  84. Applebaum AJ, Kryza-Lacombe M, Buthorn J, DeRosa A, Corner G, Diamond EL (2016) Existential distress among caregivers of patients with brain tumors: a review of the literature. Neurooncol Pract 3:232–244. https://doi.org/10.1093/nop/npv060

    Article  PubMed  Google Scholar 

  85. Ford E, Catt S, Chalmers A, Fallowfield L (2012) Systematic review of supportive care needs in patients with primary malignant brain tumors. Neuro Oncol 14:392–404. https://doi.org/10.1093/neuonc/nor229

    Article  PubMed  PubMed Central  Google Scholar 

  86. Boele FW, Given CW, Given BA, Donovan HS, Schulz R, Weimer JM, Drappatz J, Lieberman FS, Sherwood PR (2017) Family caregivers’ level of mastery predicts survival of patients with glioblastoma: a preliminary report. Cancer 123:832–840. https://doi.org/10.1002/cncr.30428

    Article  PubMed  CAS  Google Scholar 

  87. Fortunato JT, Van Harn M, Haider SA, Phillips J, Walbert T (2021) Caregiver perceptions of end-of-life care in patients with high-grade glioma. Neurooncol Pract 8:171–178. https://doi.org/10.1093/nop/npaa077

    Article  PubMed  Google Scholar 

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Funding

This study was supported by the Department of Neurosurgery and the Hermelin Brain Tumor Center, Henry Ford Health System.

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Authors and Affiliations

  1. Department of Neurology, Henry Ford Health System and Wayne State University, 2799 W Grand Blvd, Detroit, MI, 48202, USA

    Natalie E. Stec & Tobias Walbert

  2. Department of Neurosurgery, Henry Ford Health System and Wayne State University, 2799 W Grand Blvd, Detroit, MI, 48202, USA

    Tobias Walbert

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  1. Natalie E. Stec
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  2. Tobias Walbert
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Correspondence to Tobias Walbert.

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Stec, N.E., Walbert, T. Neuro-oncology and supportive care: the role of the neurologist. Neurol Sci 43, 939–950 (2022). https://doi.org/10.1007/s10072-021-05862-3

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